On the contribution of the phagocytosis and the solubilization to the iron oxide nanoparticles retention in and elimination from lungs under long-term inhalation exposure

Sutunkova, Marina P.; Katsnelson, Boris A.; Privalova, Larisa I.; Gurvich, Vladimir B.; Konysheva, L K; Shur, V. Ya.; Шишкина, Е. В.; Minigalieva, Ilzira A.; Solovjeva, S.N.; Grebenkina, Svetlana V.; Zubarev, I. V.

doi:10.1016/j.tox.2016.07.006

Cited by 44 publications

(34 citation statements)

References 26 publications

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“…This reduction was likely to be an immediate consequence of the subacute stress caused by immobilization at the beginning of the experiment when the rats were not yet sufficiently well adapted to it. Incidentally, we did not observe this effect during months of exposure in the same setup in three different experiments involving other NP species [6][7][8].…”

Section: Neutrophil Leukocytes Alveolar Macrophagesmentioning

confidence: 54%

“…Particularly noteworthy are changes in the hippocampus associated with the penetration of nanoparticles into the brain from the nose as a primary site for their deposition. Such penetration is characteristic of inhaled NPs of any chemical composition, as has been discovered in a number of studies [3][4][5], including ours [6][7][8].…”

Section: Introductionmentioning

confidence: 52%

“…Previously, we demonstrated that the deposition of nanoparticles in the lungs as a result of intratracheal administration [11][12][13][14] or inhalation exposure [6][7][8] caused a response in the lower airways that was essentially similar to but a lot more intensive than the one provoked by similar exposures to low-soluble highly cytotoxic micrometer particles, such as, for instance, quartz dust [15,16]. This response manifests itself as an increase in the cellularity of the bronchoalveolar lavage fluid (BALF), mainly at the expense of neutrophil leukocytes.…”

Section: Resultsmentioning

confidence: 99%

“…It gives minute ventilation, 214 mL, which almost exactly corresponds to the above given highest experimental value and thus seems to be an extreme estimate. In our previous inhalation studies with iron oxide [6], silica [40], and nickel oxide [41] nanoparticles, we calculated particle deposition based on the minute ventilation value of 100 mL, which is close to the median of the above experimental range but of course somewhat arbitrary. (2) The pulmonary deposition fraction of inhaled NPs may be estimated to be equal to 0.52, which is close to the lowest of the differently substantiated assessments given by [42] but much higher as compared with 0.124, which value is assumed to be the alveolar region deposition fraction for 20 nm particles according to the same MPPD model.…”

Section: Methodsmentioning

confidence: 99%

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Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

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Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development).

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Section: Neutrophil Leukocytes Alveolar Macrophagesmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

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“…can generally be addressed only through experiments on the whole mammalian organism. In such experiments carried out during 2010-2016 we [72]- [87] demonstrated that Mt-NPs should be considered one of the most dangerous occupational and environmental hazards due to their especially high toxicity and virtually obligatory genotoxicity.…”

mentioning

confidence: 99%

Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

Privalova¹,

Katsnelson²,

Sutunkova³

et al. 2017

JEP

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Especially high health risks associated with impacts of metallic nanoparticles (Me-NPs) and their presence in the workplace and ambient air of not only the nano-industry but also of some long-existing traditional technologies make it necessary, along with keeping respective dangerous exposures as low as possible, to look for ways of increasing the organism's resistance to them. Based on theoretical premises of such beneficial interference with toxicokinetics and toxicodynamics of Me-NPs developed by our research team and on understanding general and specific key mechanisms of different Me-NPs' toxic action, we proposed several bioprotective complexes (BPCs) comprising mainly pectin, some vitamins, glutamate, glycine, N-acetylcysteine, omega-3 PUFA, and different essential trace elements. Results of our animal experiments with different Me-NPs showed that, against the background of such BPCs' oral administration, the integral and specific toxicity of Me-NPs and even their genotoxicity can be markedly attenuated. Therefore we would recommend to further develop this vector of nano-toxicological research. KeywordsNanoparticles, Toxic metals, Bioptotectors BackgroundNanoparticles (NPs) of elemental metals and some metalloids, and even more so 845of their oxides are of special interest in the framework of health risk assessment and risk management problems. Along with engineered metallic NPs (Me-NPs), there usually exists a substantial nanoscale fraction of condensation aerosols generated as byproducts of many long existing and new technologies (steel and nonferrous metallurgies, arc-welding, laser metals treatment, etc) and thus polluting both workroom and ambient air in respective industries and adjacent areas. Other fractions of such aerosols are 8 usually presented mostly be submicron particles with dimensions above 100 nm. Examples illustrating these statements are given in Figure 1 and Figure 2.In such industries air is, as a rule, polluted by multi-component mixtures of chemically different particles of similar or dissimilar geometry. For instance, in arc-welding and alloyed steel making one usually finds different combinations of iron, chromium, nickel, manganese and silicon oxides, while in crude copper smelting and copper refining-those of copper, lead, cadmium, zinc, and arsenic oxides.In the vast nano-toxicological literature of the last decade, studies concerned with the assessment of Me-NP toxicity are quite numerous. We can refer, for example, to several works devoted to the same Me-NPs that were the sub- lot of others). However, the prevailing majority of these researchers assessed adverse effects of Me-NPs in vitro on stable cell lines. This approach features a number of well-known advantages relating, in particular, to analysis of primary toxicity mechanisms on cellular and sub-cellular levels. At the same time, any extrapolation of the results of these experiments to the organism level and even the organ-systemic level is associated with a number of uncertainties and assumptions. Moreover,...

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Experimental Research into Metallic and Metal Oxide Nanoparticle Toxicity In Vivo

Katsnelson

Privalova

Sutunkova

et al. 2017

Bioactivity of Engineered Nanoparticles

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On the contribution of the phagocytosis and the solubilization to the iron oxide nanoparticles retention in and elimination from lungs under long-term inhalation exposure

Cited by 44 publications

References 26 publications

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

Experimental Research into Metallic and Metal Oxide Nanoparticle Toxicity In Vivo

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