Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

Privalova, Larisa I.; Katsnelson, Boris A.; Sutunkova, Marina P.; Minigalieva, Ilzira A.; Gurvich, Vladimir B.; Makeyev, Oleg H.; Shur, V. Ya.; Valamina, Irene E.; Klinova, Svetlana V.; Шишкина, Е. В.; Zubarev, I. V.

doi:10.4236/jep.2017.88053

Cited by 7 publications

(5 citation statements)

References 89 publications

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“…However, it is clear that maintaining such low levels of exposure in actual industrial occupational settings could be a major challenge. This makes it especially important to find ways to enhance the resistance of the organism to nano-impacts by means of safe bioprotectors [24]. It is therefore important that in the experiments presented in this paper, we have proved the possibility of such bioprotection (specifically, the significant attenuation of the genotoxic effect of NiO-NPs).…”

Section: Discussionmentioning

confidence: 93%

“…Based on the theoretical premises [22,24] and previous successful experiences in attenuating the toxicity of different metallic nanoparticles, including Ag-NPs [43], CuO-NPs [44], and some MeO-NPs combinations including NiO-NPs + Mn 3 O 4 -NPs [23], CuO-NPs + PbO-NPs + ZnO-NPs [26], and Al 2 O 3 -NPs + TiO 2 -NP + SiO 2 -NPs [27]), we chose the following substances for inclusion into what we call a “bioprotective complex” (BPC) to be administered per os along with the 3-month inhalation exposure to NiO-NP:Glutamate is an effective cell membrane stabilizer acting through the intensification of the ATP synthesis under exposure to the damaging action of various cytotoxic particles (e.g., [22,45,46,47]). At the same time, it is one of the precursors of glutathione, which is a powerful cell protector against the oxidative stress.…”

Section: Methodsmentioning

confidence: 99%

“…Although we developed [22] a combination of bioprotectors and successfully tested it against combined nickel-manganese NiO-NP + Mn 3 O 4 -NP intoxications [23], it was still unknown whether such a combination was effective against the toxicity of NiO-NPs proper. Moreover, despite our wide experience in bioprotection against acute and subchronic effects of various metals in the form of ions or nanoparticles [22,24], we have not yet performed such studies for chronic inhalation nano-intoxications.…”

Section: Introductionmentioning

confidence: 99%

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Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Sutunkova

Solovyeva

Minigalieva

et al. 2019

IJMS

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Rats were exposed to nickel oxide nanoparticles (NiO-NP) inhalation at 0.23 ± 0.01 mg/m3 for 4 h a day 5 times a week for up to 10 months. The rat organism responded to this impact with changes in cytological and some biochemical characteristics of the bronchoalveolar lavage fluid along with a paradoxically little pronounced pulmonary pathology associated with a rather low chronic retention of nanoparticles in the lungs. There were various manifestations of systemic toxicity, including damage to the liver and kidneys; a likely allergic syndrome as indicated by some cytological signs; transient stimulation of erythropoiesis; and penetration of nickel into the brain from the nasal mucous membrane along the olfactory pathway. Against a picture of mild to moderate chronic toxicity of nickel, its in vivo genotoxic effect assessed by the degree of DNA fragmentation in nucleated blood cells (the RAPD test) was pronounced, tending to increasing with the length of the exposure period. When rats were given orally, in parallel with the toxic exposure, a set of innocuous substances with differing mechanisms of expected bioprotective action, the genotoxic effect of NiO-NPs was found to be substantially attenuated.

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Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Sutunkova

Solovyeva

Minigalieva

et al. 2019

IJMS

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“…At the same time, it would be of practical importance to find bioprotectors which, if administered in innocuous doses, could enhance the resistance of the organism to the effect of the MeO-NP [ 11 , 17 , 51 , 52 ]. Interestingly, one of the very few studies on nano-toxicity attenuation performed outside our team was concerned with the hepatotoxicity of just TiO 2 -NP ameliorated by means of Cinnamomum cassia [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors

Minigalieva

Katsnelson

Privalova

et al. 2018

IJMS

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Stable suspensions of metal/metalloid oxide nanoparticles (MeO-NPs) obtained by laser ablation of 99.99% pure elemental aluminum, titanium or silicon under a layer of deionized water were used separately, or in three binary combinations, or in a ternary combination to induce subchronic intoxications in rats. To this end, the MeO-NPs were repeatedly injected intraperitoneally (i.p.) 18 times during 6 weeks before measuring a large number of functional, biochemical, morphological and cytological indices for the organism’s status. In many respects, the Al2O3-NP was found to be the most toxic species alone and the most dangerous component of the combinations studied. Mathematical modeling with the help of the Response Surface Methodology showed that, as well as in the case of any other binary toxic combinations previously investigated by us, the organism’s response to a simultaneous exposure to any two of the MeO-NP species under study was characterized by a complex interaction between all possible types of combined toxicity (additivity, subadditivity or superadditivity of unidirectional action and different variants of opposite effects) depending on which outcome this type was estimated for and on effect and dose levels. With any third MeO-NP species acting in the background, the type of combined toxicity displayed by the other two remained virtually the same or changed significantly, becoming either more or less unfavorable. Various harmful effects produced by the (Al2O3-NP + TiO2-NP + SiO2-NP)-combination, including its genotoxicity, were substantially attenuated by giving the rats per os during the entire exposure period a complex of innocuous bioactive substances expected to increase the organism’s antitoxic resistance.

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“…Повышение устойчивости к цитотоксическим эффектам ведет к возможному снижению пульмонотоксичности. Научным коллективом, в который входят соавторы статьи, разрабатывается и внедряется такой подход, как биологическая профилактика, направленная на повышение устойчивости организма к токси ческим воздействиям [11][12][13]. Исследования, проведенные ранее, показали эффективность различных биопрофилактических средств (включая глутамат натрия, йод, антиоксиданты) против вредных эффектов (фиброгенности и цитотоксичности) диоксида кремния [14][15][16][17][18].…”

Section: гигиена трудаunclassified

Increasing the Resistance of the Body to Adverse Cytotoxic Effects of Amorphous Silicon Dioxide Nanoparticles

Соловьева¹,

Sutunkova²,

Minigalieva³

et al. 2020

PH&LE

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Introduction: Amorphous silicon dioxide nanoparticles of (SiNPs) are among the most common nanomaterials today. Besides, industrial aerosols formed by condensation and containing a significant proportion of SiNPs are spontaneously produced by a number of pyrometallurgical and welding processes. A significant number of individuals are therefore exposed to SiNPs in the occupational setting or polluted ambient air and while using this nanomaterial. The purpose of our experimental study was to develop a preventive method promoting the resistance of the organism to adverse cytotoxic effects of amorphous silicon dioxide nanoparticles. Materials and methods: White laboratory rats received a monthly course of a specially developed bioprophylactic complex (BPC) before a single intratracheal instillation of a SiNPs suspension at a concentration of 0.5 mg/mL. The suspension was obtained by laser ablation of thin sheet targets of the appropriate material of 99.99 % purity in sterile deionized water. The average diameter of SiNPs was 43 ± 11 nm. Cytological (the number of bronchoalveolar macrophages and neutrophils and their ratio) and cytochemical indices of the bronchoalveolar lavage (BAL) fluid (alkaline phosphatase, alanine aminotransferase, gamma-glutamyl transpeptidase, amylase, and lactate dehydrogenase) were evaluated at 24 hours after the injection. The bioprophylactic complex was administered to the animals with feed and drink and included monosodium glutamate, fish oil rich in omega-3 polyunsaturated fatty acids (PUFAs), iodine, and an antioxidant complex of selenium, quercetin (rutoside), and vitamins A, E, and C. Conclusions: Our findings show that changes in both cytological and biochemical BAL parameters proved a positive health effect of premedication that helped reduce cytotoxicity of SiNPs exposure.

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Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

Cited by 7 publications

References 89 publications

Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors

Increasing the Resistance of the Body to Adverse Cytotoxic Effects of Amorphous Silicon Dioxide Nanoparticles

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