Experimental Research into Metallic and Metal Oxide Nanoparticle Toxicity In Vivo

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

“…However, from the standpoint of human health risk assessment, it is much more important that PbO particles pollute workplace and ambient air in aerosol form in such long-established and major industries as copper and lead smelters and refineries. These polluting aerosols, resulting from the evaporation of molten metal in pyrometallurgy and its condensation in the air due to cooling and oxidation, contain a substantial proportion of particles falling within the nano-range [1].…”

Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors

“…The toxicity of metal nanoparticles and, especially, of metal oxide ones (MeO-NPs) has been a subject of extensive studies conducted by our team for the last few years [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Apart from a range of purposely manufactured (“engineered”) NPs, very important are their “natural” analogues always present in the workplace and ambient air of arc-welding and metallurgical operations.…”

Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors

“…Most likely, the metals impact directly on the kidneys not so much as persistent MeO-NP as in the form of ions released by them as a result of solubilization in biological milieus, which has been repeatedly proven by us (e.g. [15,17]). We may therefore assume that the special nephrotoxicity of TiO2-NP is explained just by its highest in vivo solubility, which we modeled by adding fetal bovine serum (FBS) in vitro to each of the nano-suspensions ( Figure 7).…”

“…The toxicity of metal nanoparticles (Me-NPs) and, especially, metal oxide ones (MeO-NPs) has been a subject of extensive studies for our team for the last few years [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. In these endeavors, we have been motivated by the special interest of this class of substances -not so much because it comprises a lot of purposely manufactured ("engineered") NPs as because their analogues are virtually always present in the workplace and ambient air of arc-welding and metallurgical operations, constituting a substantial fraction in the particle size distribution of the polluting condensation aerosols (see examples in [17]). Meanwhile, it is multiple-factor rather than single-agent potentially hazardous nano-impacts on human health that are a common feature of these environments.…”

“…At the same time, it would be of practical importance to find bioprotectors which, if administered in innocuous doses, could enhance the resistance of the organism to the effect of the given combination as it was first done by our team for Ag-NP [7], CuO-NP [10] and for the combinations (NiO-NP+ Mn3O4-NP) [11] or (PbO-NP + ZnO-NP + CuO-NP) [17] (the theoretical and methodological aspects of this line of research have been set out in [51] and [52]). Interestingly, one of the very few studies on nanotoxicity attenuation performed outside our team was concerned with the hepatotoxicity of just TiO2-NP ameliorated by means of Cinnamomum cassia [28].…”