A comprehensive review of microRNA-related polymorphisms in gastric cancer

Han, Baowei; Li, Z H; Liu, S F; Han, Hongfeng; Dong, Shujun; Zou, Hai-Jian; Sun, Ruili; Jia, Jun

doi:10.4238/gmr.15028289

Cited by 10 publications

(6 citation statements)

References 38 publications

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“…Consequently, CC homozygotes, which undergo a change in the pattern of the expression of the mir196a2 gene, are more susceptible to cancer. 28 In conclusion, our findings showed that CT heterozygosity in mir23a gene significantly related with risk of multiple sclerosis (OR=2.3, p=0.048). However, extensive studies are required to gain more reliable and authentic results.…”

Section: Discussionmentioning

confidence: 58%

“…24 Moreover, miR155 has been characterized as a component of the primary macrophage response to different types of inflammatory mediators such as IFN-β or Tumor Necrosis Factor-α (TNF-α). [25][26][27][28][29] It has been shown that miR155 is induced by bacterial lipopolysaccharide (LPS) in a human monocytic cell line. 30 Some study in Egyptian population proposed that mir196a2 rs11614913 polymorphism could be associated with asthma severity.…”

Section: Introductionmentioning

confidence: 99%

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Genetic Variation in Intergenic and Exonic miRNA Sequence and Risk of Multiple Sclerosis in the Isfahan Patients

Golshani

Hojati

Sharifzadeh

et al. 2018

IJAAI

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MicroRNAs (miRNAs), have been documented to perform a key role in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory and autoimmune disease. Recent studies have shown that single nucleotide polymorphism in the sequence of the miRNA may change their production and expression which can lead to miRNA dysfunction and pathogenicity. Some studies have reported the relationship between miRNA polymorphism and the increased risk of autoimmune disease. This study was conducted to investigate the association between mir155 rs767649, mir196a2 rs11614913 and mir23a rs3745453 polymorphism and the risk of multiple sclerosis in the Iranian MS patients in Isfahan. A population of 80 patients and the same number control were selected. After DNA extraction, genotyping was performed through tetra amplification refractory mutation system-PCR method (T ARMS PCR). The frequencies of TT, TC and CC genotypes of mir23a were 46, 35 and 20% in MS patients and 42, 14 and 24 in healthy subjects respectively. These results showed that individuals carrying the genotypes of rs3745453 TC had a 2.3-fold increased risk of MS (OR=2.3, p=0.048). There was no significant difference between genotypes and allele frequency of mir155 and mir196a2 in patients and healthy controls (p>0.05). Our findings specified that CT heterozygosity in mir23a gene significantly related with risk of MS. Unlike mir155 and mir196a2, mir23a rs3745453 may have contributed to the etiology of MS in Isfahan patients. However, extensive studies are required to gain more reliable and authentic results.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Genetic Variation in Intergenic and Exonic miRNA Sequence and Risk of Multiple Sclerosis in the Isfahan Patients

Golshani

Hojati

Sharifzadeh

et al. 2018

IJAAI

View full text Add to dashboard Cite

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“…Gastric cancer (GC) is one of the most common malignant cancers and the 3rd leading cause of tumor death worldwide . The pathogenesis and risk factors of GC is complex and are associated with several factors . Smoking, helicobacter pylori infection, alcohol consumption, pernicious anemia, unhealthy diet, and old age are the risks factors that lead to the initiation of GC .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] The pathogenesis and risk factors of GC is complex and are associated with several factors. [7][8][9][10] Smoking, helicobacter pylori infection, alcohol consumption, pernicious anemia, unhealthy diet, and old age are the risks factors that lead to the initiation of GC. [11][12][13][14] Upon diagnosis, metastatic or locally advanced disease could be found in about two-thirds of GC patients.…”

Section: Introductionmentioning

confidence: 99%

HOTAIR enhanced paclitaxel and doxorubicin resistance in gastric cancer cells partly through inhibiting miR‐217 expression

Wang

Qin

Guan

et al. 2018

J of Cellular Biochemistry

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Drug resistance is a big obstacle for clinical anti-tumor treatment outcome. However, the role of HOTAIR in drug resistance in gastric cancer (GC) remains unknown. In this study, we showed that overexpression of HOTAIR enhanced paclitaxel and doxorubicin resistance in GC cells. Furthermore, the expression of HOTAIR was upregulated in GC tissues and higher expression of HOTAIR was associated with late stage. In addition, we showed that miR-217 expression was lower in GC tissues compared with the paired non-tumour tissues and downregulated expression of miR-217 was correlated with late stage. Interestingly, the expression of miR-217 was negatively correlated with HOTAIR expression in GC tissues. Ectopic expression of HOTAIR increased GC cell proliferation, cell cycle, and migration. Elevated expression of HOTAIR suppressed miR-217 expression and enhanced GPC5 and PTPN14 expression. Furthermore, we demonstrated that overexpression of miR-217 suppressed paclitaxel and doxorubicin resistance in GC cells. Ectopic expression of HOTAIR promoted drug resistance and increased GC cell proliferation, cell cycle, and migration by targeting miR-217. These data suggested that overexpression of HOTAIR enhanced paclitaxel and doxorubicin resistance in GC cells through inhibiting miR-217 expression.

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“…4,5 Mutations in the promoter regions of certain miRNAs usually cause changes in their expression. 6,7 In addition, single nucleotide polymorphisms (SNPs) located in some miRNAs may be closely related to their binding ability to target mRNAs. 8 Therefore, these SNPs might affect the individualized differences in their expression or functions; therefore, it predict the prognosis of certain diseases.…”

mentioning

confidence: 99%

Micro-RNA-21 rs1292037 A>G polymorphism can predict hepatocellular carcinoma prognosis (HCC), and plays a key role in cell proliferation and ischemia-reperfusion injury (IRI) in HCC cell model of IRI

Tang

Wang

et al. 2020

SMJ

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A comprehensive review of microRNA-related polymorphisms in gastric cancer

Cited by 10 publications

References 38 publications

Genetic Variation in Intergenic and Exonic miRNA Sequence and Risk of Multiple Sclerosis in the Isfahan Patients

Genetic Variation in Intergenic and Exonic miRNA Sequence and Risk of Multiple Sclerosis in the Isfahan Patients

HOTAIR enhanced paclitaxel and doxorubicin resistance in gastric cancer cells partly through inhibiting miR‐217 expression

Micro-RNA-21 rs1292037 A>G polymorphism can predict hepatocellular carcinoma prognosis (HCC), and plays a key role in cell proliferation and ischemia-reperfusion injury (IRI) in HCC cell model of IRI

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