Micro-RNA-21 rs1292037 A&gt;G polymorphism can predict hepatocellular carcinoma prognosis (HCC), and plays a key role in cell proliferation and ischemia-reperfusion injury (IRI) in HCC cell model of IRI

Wu, Chaoyu; Tang, Gongen; Wang, Xiaoying; Zhang, Jian; Chen, Shuhua; Lu, Cuihong; Zhang, Dongqin; Li, Yun

doi:10.15537/smj.2020.4.24994

Cited by 5 publications

(4 citation statements)

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“…The determined nucleotide sequences of the 4 species’ chloroplast genomes ranged narrowly from 153,016 bp to 153,631 bp, with a similar gene pattern of 132 genes, which has been observed in other Scrophularia plants ( Figure 2 , Table 1 ) [ 32 , 45 ]. The LSC region contains most of the genes required for chloroplast function, including those involved in photosynthesis, carbon fixation, and amino acid synthesis; the SSC region contains a smaller number of genes, including those involved in RNA processing and protein synthesis; the IR regions contain genes involved in photosynthesis, as well as rRNA genes and tRNA genes [ 46 , 47 , 48 ]. The observed conservation of the S. ningpoensis complex’s chloroplast genomes can be attributed to the similarities in the morphological characters and habitat preferences, as well as the low rate of chloroplast substitution [ 27 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization and Comparative Analysis of Chloroplast Genomes of Medicinal Herb Scrophularia ningpoensis and Its Common Adulterants (Scrophulariaceae)

Guo

Wang

et al. 2023

IJMS

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Scrophularia ningpoensis, a perennial medicinal plant from the Scrophulariaceae family, is the original species of Scrophulariae Radix (SR) in the Chinese Pharmacopoeia. This medicine is usually deliberately substituted or accidentally contaminated with other closely related species including S. kakudensis, S. buergeriana, and S. yoshimurae. Given the ambiguous identification of germplasm and complex evolutionary relationships within the genus, the complete chloroplast genomes of the four mentioned Scrophularia species were sequenced and characterized. Comparative genomic studies revealed a high degree of conservation in genomic structure, gene arrangement, and content within the species, with the entire chloroplast genome spanning 153,016–153,631 bp in full length, encoding 132 genes, including 80 protein-coding genes, 4 rRNA genes, 30 tRNA genes, and 18 duplicated genes. We identified 8 highly variable plastid regions and 39–44 SSRs as potential molecular markers for further species identification in the genus. The consistent and robust phylogenetic relationships of S. ningpoensis and its common adulterants were firstly established using a total of 28 plastid genomes from the Scrophulariaceae family. In the monophyletic group, S. kakudensis was determined to be the earliest diverging species, succeeded by S. ningpoensis. Meanwhile, S. yoshimurae and S. buergeriana were clustered together as sister clades. Our research manifestly illustrates the efficacy of plastid genomes in identifying S. ningpoensis and its counterfeits and will also contribute to a deeper understanding of the evolutionary processes within Scrophularia.

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Section: Discussionmentioning

confidence: 99%

Characterization and Comparative Analysis of Chloroplast Genomes of Medicinal Herb Scrophularia ningpoensis and Its Common Adulterants (Scrophulariaceae)

Guo

Wang

et al. 2023

IJMS

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“…SNPs in the miRNA coding genes are seen to affect the binding a nity and binding ability of miRNAs, which can consequently affect the expression of the miRNA target genes (9). Although miR-21 rs1292037 is seen to be correlated with the prognosis of hepatocellular carcinoma and cervical cancer, there is no reported evidence on the association of this reference SNP and T1DM (14,22).…”

Section: -Discussionmentioning

confidence: 99%

Influence of rs1292037 Genetic Variant on miR-21 Gene Expression in Patients with type 1 Diabetes Mellitus

Bayat¹,

Salehi²,

Dalili³

et al. 2021

Preprint

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BackgroundMicroRNAs (miRNAs) are small non-coding RNA molecules that play a pivotal role in the central dogma of molecular biology by regulating gene expression. Alterations in the expression pattern of miRNAs are seen to be linked with several human diseases including autoimmune diseases such as pediatric type 1 diabetes mellitus (T1DM). Single nucleotide polymorphism (SNP) of the miRNAs coding genes can influence pancreatic development and insulin secretion. We contemplated a relation between miR-21 expression level as well as miR-21 rs1292037 SNP and pediatric T1DM.ResultsThe heterozygous T/C genotype was seen to be more common amongst T1DM patients than amongst controls (OR = 2.74 (1.78-4.27), P<0.0001). The C allele was more frequent in patients than in control subjects (OR = 1.36 (1.03-0.8), P = 0.02). miR-21 expression was seen to be upregulated in patients compared to the controls by more than twofold (p<0.0001). In the study population, miR-21 was found to be significantly upregulated when carrying the T/C genotype. ConclusionsWe report that the miR-21 rs1292037 variant is related to T1DM. Our study also suggests that the miR-21 expression level is upregulated in T1DM patients compared to the control subjects.

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“…Conversely, miR-519a-3p has been implicated in promoting liver metastasis in gastric cancer and is associated with an unfavorable prognosis ( 10 , 11 ). Several studies have identified miRNA-21 rs1292037 and miR-149 rs2292832C/T as potential prognostic indicators for hepatocellular carcinoma ( 12 , 13 ). Additionally, investigations have linked miR-34 rs4938723 and miR-195-5p to the prognosis of colorectal cancer ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

MiRNA polymorphisms affect the prognosis of gastric cancer: insights from Xianyou, Fujian

Wu,

Zhang,

Lyu

et al. 2024

Front. Oncol.

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IntroductionGastric cancer, characterized by high incidence and substantial disease burden, has drawn continuous attention regarding its occurrence and prognosis. Genetics plays a crucial role in influencing the prognosis of gastric cancer, and single nucleotide polymorphisms are closely associated with the occurrence, development, and prognosis of this malignant tumor. Our study aims to conduct survival analysis on patients carrying different single nucleotide polymorphisms, exploring the relationship between miRNA single nucleotide polymorphisms and the prognosis of gastric cancer.MethodsGenetic data from 344 patients in Xianyou, Fujian, formed the basis of our study. We delineated the survival rate and median survival time, utilizing the log-rank test and COX regression analysis as statistical tools.ResultsUpon stratifying the data by sex or operation, it was discerned that the GG genotype at MSH2 rs17502941 independently posed a heightened risk for gastric cancer. Other stratification analyses suggested that the subsequent single nucleotide polymorphisms were correlated with patient prognosis: rs17502941, rs884225, rs1468063, rs7143252, and rs2271738.DiscussionThe outcomes of this study strongly suggest that miRNA polymorphisms significantly influence the survival time of gastric cancer patients and can serve as effective predictors for the prognosis of gastric cancer.

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Micro-RNA-21 rs1292037 A>G polymorphism can predict hepatocellular carcinoma prognosis (HCC), and plays a key role in cell proliferation and ischemia-reperfusion injury (IRI) in HCC cell model of IRI

Abstract: Objectives: To assess the predictive function of miR-21 rs1292037 A>G polymorphism in survival and ischemia-reperfusion injury (IRI) in hepatocellular carcinoma (HCC) patients.

Cited by 5 publications

References 27 publications

Characterization and Comparative Analysis of Chloroplast Genomes of Medicinal Herb Scrophularia ningpoensis and Its Common Adulterants (Scrophulariaceae)

Characterization and Comparative Analysis of Chloroplast Genomes of Medicinal Herb Scrophularia ningpoensis and Its Common Adulterants (Scrophulariaceae)

Influence of rs1292037 Genetic Variant on miR-21 Gene Expression in Patients with type 1 Diabetes Mellitus

MiRNA polymorphisms affect the prognosis of gastric cancer: insights from Xianyou, Fujian

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