Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes

Abstract

Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.

Dietary BCAA Intake Is Associated with Demographic, Socioeconomic and Lifestyle Factors in Residents of São Paulo, Brazil

“…Regarding the BCAA intake, our results were similar to the US adult population, in that the major food contributors were red meat (~37%), milk (~12%) and fish (~8%) [6]. However, these results are different from those observed in Japan, whose lowest food contributor with total BCAA intake in the adult population was red meat with approximately 14.9% of consumption in men and 13.7% in women [5].…”

“…In this context, over nutrition affects the rising of BCAA circulating in the plasma, leading to increase flux of these amino acids through their catabolic pathways [6]. In humans, these amino acids play regulatory roles in insulin and glucose metabolism.…”

High dietary intake of branched‐chain amino acids is associated with an increased risk of insulin resistance in adults

“…Studies on circulating serum concentrations of BCAAs and insulin metabolism or IR have shown controversial findings; some studies indicate impaired BCAA metabolism and increased plasma levels to be associated with a higher risk of IR or type 2 diabetes and preceding hyperglycemia, whereas other studies indicate that increased plasma BCAA concentrations have no effect on insulin sensitivity . Similarly, the limited studies available assessing the association between BCAA intake from the diet and the risk of diabetes have yielded inconsistent results, with one study indicating that a higher intake of these amino acids was associated with a decreased risk of diabetes and the other study reporting that high consumption of BCAAs increases the risk of diabetes …”

Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial

“…In large prospective epidemiologic studies, a higher intake of BCAAs has been significantly associated with a higher subsequent risk of developing type 2 diabetes [31]. Randomised dietary interventions (in weight-loss trials) showed that decreases in plasma tyrosine were associated with improvements in insulin resistance independent of weight loss [32].…”