North American ginseng inhibits myocardial NOX2-ERK1/2 signaling and tumor necrosis factor-α expression in endotoxemia

Wu, Yan; Qin, Chaoyi; Lu, Xiangru; Marchiori, Jocelyn; Feng, Qingping

doi:10.1016/j.phrs.2016.06.010

Cited by 18 publications

(10 citation statements)

References 34 publications

(40 reference statements)

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“…Aqueous extract of AG inhibited superoxide generation in the heart of mice challenged with lipopolysaccharide to induce endotoxemia, a model of sepsis [83]. A similar effect was observed in cultured cardiomyocytes.…”

Section: Pro-health Effects Of American Ginsengmentioning

confidence: 86%

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

et al. 2019

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Panax quinquefolium L. (American Ginseng, AG) is an herb characteristic for regions of North America and Asia. Due to its beneficial properties it has been extensively investigated for decades. Nowadays, it is one of the most commonly applied medical herbs worldwide. Active compounds of AG are ginsenosides, saponins of the glycosides group that are abundant in roots, leaves, stem, and fruits of the plant. Ginsenosides are suggested to be primarily responsible for health-beneficial effects of AG. AG acts on the nervous system; it was reported to improve the cognitive function in a mouse model of Alzheimer’s disease, display anxiolytic activity, and neuroprotective effects against neuronal damage resulting from ischemic stroke in animals, demonstrate anxiolytic activity, and induce neuroprotective effects against neuronal damage in ischemic stroke in animals. Administration of AG leads to inhibition of hypertrophy in heart failure by regulation of reactive oxygen species (ROS) in mice as well as depletion of cardiac contractile function in rats. It also has an anti-diabetic and anti-obesity potential as it increases insulin sensitivity and inhibits formation of adipose tissue. AG displays anti-cancer effect by induction of apoptosis of cancer cells and reducing local inflammation. It exerts antimicrobial effects against several pathogenic strains of bacteria. Therefore, AG presents a high potential to induce beneficial health effects in humans and should be further explored to formulate precise nutritional recommendations, as well as to assess its value in prevention and therapy of some disorders, including cancer.

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Section: Pro-health Effects Of American Ginsengmentioning

confidence: 86%

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

et al. 2019

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“…Considering the universality of NO and Ca 2+ signaling in health and disease, we believe the Primary culture of neonatal cardiomyocytes. Neonatal cardiomyocytes were isolated and cultured as described previously [41][42][43]. Forty-eight hours after seeding, cells were used for Ca 2+ imaging and patch clamp.…”

Section: Discussionmentioning

confidence: 99%

S-Nitrosylation of STIM1 by neuronal nitric oxide synthase inhibits store-operated Ca²⁺ entry

Gui

Zhu

et al. 2018

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Store-operated Ca 2+ entry (SOCE) mediated by stromal interacting molecule-1 (STIM1) andOrai1 represents a major route of Ca 2+ entry in mammalian cells and is initiated by STIM1 oligomerization in the endoplasmic or sarcoplasmic reticulum (ER/SR). However, the effects of nitric oxide (NO) on STIM1 function are unknown. Neuronal NO synthase (nNOS) is located in the SR of cardiomyocytes. Here, we show that STIM1 is susceptible to S-nitrosylation. nNOS deficiency or inhibition enhanced Ca 2+ release-activated Ca 2+ channel current (I CRAC ) and SOCE in cardiomyocytes. Consistently, NO donor S-nitrosoglutathione (GSNO) inhibited STIM1 puncta formation and I CRAC in HEK293 cells, but this effect was absent in cells expressing the Cys49Ser/Cys56Ser STIM1 double mutant. Furthermore, NO donors caused Cys49 and Cys56specific structural changes associated with reduced protein backbone mobility, increased thermal stability and suppressed Ca 2+ -depletion-dependent oligomerization of the luminal Ca 2+ -sensing region of STIM1. Collectively, our data show that S-nitrosylation of STIM1 suppresses oligomerization via enhanced luminal domain stability and rigidity, and inhibits SOCE in cardiomyocytes.

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“…Subsequently, it was found that the neutral polysaccharide PPQN in PQR has a therapeutic effect on inflammation and inflammation-related diseases by inhibiting the release of inflammatory mediators (NO) and cytokines (TNF-α, IL-1β, IL-6) (Wang et al, 2015b). The water extract of PQR could significantly inhibit the expression of NOX2, superoxide generation, ERK1/2 phosphorylation and TNF-α in the heart during endotoxemia by inhibiting the signaling pathway of NOX2-ERK1/2-TNF-α, and improve the level of inflammatory factors to improve cardiac function (Wu et al, 2016). PQR saponins could inhibit endoplasmic reticulum stress and associated chondrocytes' inflammatory response by activating the NF-κB pathway, and protect chondrocytes against triglycerides-induced endoplasmic reticulum stress and interleukin-1 -mediated apoptosis, thereby eliminating cartilage degeneration in rats (Xie et al, 2018).…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Panacis Quinquefolii Radix: A Review of the Botany, Phytochemistry, Quality Control, Pharmacology, Toxicology and Industrial Applications Research Progress

et al. 2020

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On January 2, 2020, The National Health Commission and the State Administration for Market Regulation listed Panacis Quinquefolii Radix (PQR) as a medicinal and food homologous product. PQR is the dry root of Panax quinquefolium L., which has the functions of replenishing qi and nourishing Yin, clearing heat and producing body fluid. It is often used for qi deficiency and Yin deficiency, heat exhaustion, asthma and phlegm, dry mouth and pharynx. PQR is sweet, slightly bitter and cool in nature, and enter the heart, lung and kidney meridian exerts the remedial and hygienical effect. At present, active components such as saponins, flavonoids, fatty acids, polyalkynes, volatile oils and other nutrients such as amino acids, carbohydrates, vitamins and trace elements have been isolated from PQR. Modern pharmacological studies have shown that PQR has the effects of hypoglycemic, antihypertensive, anti fatigue, anti-oxidation, anti-tumor, immunomodulatory, neuroprotective and so on. In addition, PQR is recognized as a health care product to strengthen the body and dispel diseases. It is not only the raw material of Traditional Chinese medicine preparations, but also the treasure of dietary therapy and herbal cuisine. This study not only reviewed the botany, phytochemistry and pharmacology of PQR, but also summarized its quality control, toxicity and industrial applications for the first time. This paper not only summarizes the development status of PQR, but also analyzes the shortcomings of the current research on PQR, and puts forward the corresponding solutions, in order to provide reference for future scholars to study PQR.

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North American ginseng inhibits myocardial NOX2-ERK1/2 signaling and tumor necrosis factor-α expression in endotoxemia

Cited by 18 publications

References 34 publications

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

S-Nitrosylation of STIM1 by neuronal nitric oxide synthase inhibits store-operated Ca²⁺ entry

Panacis Quinquefolii Radix: A Review of the Botany, Phytochemistry, Quality Control, Pharmacology, Toxicology and Industrial Applications Research Progress

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North American ginseng inhibits myocardial NOX2-ERK1/2 signaling and tumor necrosis factor-α expression in endotoxemia

Cited by 18 publications

References 34 publications

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

S-Nitrosylation of STIM1 by neuronal nitric oxide synthase inhibits store-operated Ca2+ entry

Panacis Quinquefolii Radix: A Review of the Botany, Phytochemistry, Quality Control, Pharmacology, Toxicology and Industrial Applications Research Progress

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S-Nitrosylation of STIM1 by neuronal nitric oxide synthase inhibits store-operated Ca²⁺ entry