JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region

Vallinoto, Izaura Maria Vieira Cayres; Vallinoto, Antônio Carlos Rosário; Pena, Giselle Priscila dos Anjos; Azevedo, Vânia Nakauth; Machado, Luiz Fernando Almeida; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo

doi:10.1016/j.bjid.2016.05.005

Cited by 4 publications

(3 citation statements)

References 42 publications

(67 reference statements)

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“…Among HIV-1-infected patients, the excretion rate was 44.1% in Serbia, 32% in Brazil, and 47.6% in Italy. 16 , 19 , 28 , 32 The high frequency of polyomavirus excretion indicates that activation of viral reaction results from the interaction between polyomavirus and HIV. Differences in selection of primers and demographics of patients may account for the divergent results on the prevalence of JCPyV.…”

Section: Discussionmentioning

confidence: 99%

Detection and analysis of variants of JC polyomavirus in urine samples from HIV-1-infected patients in China’s Zhejiang Province

Huang

et al. 2018

J Int Med Res

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ObjectivesHuman JC polyomavirus (JCPyV) infection has an increased risk of developing progressive multifocal leukoencephalopathy (PML). Different JCPyV subtypes differ in the virulence with which they cause PML. Currently, the JCPyV infection status and subtype distribution in patients with human immunodeficiency virus-1 (HIV-1) in China are still unclear. This study aimed to investigate the epidemiology and subtype distribution of JCPyV in HIV-1-infected patients in China.MethodsUrine samples from 137 HIV-1-infected patients in Zhejiang Province in China were tested for the presence of JCPyV DNA. The detected VP1 sequences were aligned and analysed using BioEdit and MEGA software.ResultsAmong urine samples from HIV-1-infected patients, 67.2% were positive for JCPyV DNA (92/137). Primarily, the type 7 strains of JCPyV were detected, among which 45.5% (15/33) were subtype 7A, 30.3% (10/33) were 7B, and 24.2% (8/33) were 7C. Six nucleotide mutations, as well as one amino acid substitution, were isolated from the patients.ConclusionsUrine samples from HIV-1-infected patients from Zhejiang Province show a high JCPyV infection rate. The most common JCPyV strains are subtypes 7A, 7B, and 7C.

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Section: Discussionmentioning

confidence: 99%

Detection and analysis of variants of JC polyomavirus in urine samples from HIV-1-infected patients in China’s Zhejiang Province

Huang

et al. 2018

J Int Med Res

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“…Among other groups of co-infections with HIV-1, it was shown that JC virus apparently has no impact on the number of CD4 + T lymphocytes and HIV-1 plasma viral load [ 56 ], while GB virus C (GBV-C, currently classified as pegivirus, HPgV1) was associated with a decrease in HIV-1 viral load, an increase in CD4 + T lymphocytes and a possible protective effect in the progression of infection to AIDS [ 57 ].…”

Section: The Impact Of Hiv-1 In the Brazilian Amazon: From Description To Current Timesmentioning

confidence: 99%

The Epidemiological Impact of STIs among General and Vulnerable Populations of the Amazon Region of Brazil: 30 years of Surveillance

Machado

Fonseca

Queiroz

et al. 2021

Viruses

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Sexually transmitted infections (STIs) represent a worldwide public health problem and, although many of them are curable, they continue to be neglected, especially in areas with a low human development index, such as in the northern region of Brazil. This review describes the results of 30 years of studies at the Virus Laboratory at the Federal University of Pará, including the prevalence and molecular epidemiology of HIV-1, HTLV-1/2, HPV, HBV, Treponema pallidum and Chlamydia trachomatis among urban and non-urban populations, and also in vulnerable groups in the Brazilian Amazon. Control strategies and challenges in preventing STIs are discussed considering this immense geographic region, where essential health services are unable to reach the entire population, especially the most vulnerable, such as female sex workers, people who use illicit drugs, remnants of quilombolos and indigenous communities.

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“…Usually, a higher prevalence of JCV is observed in the Americas than on the African continent ( Chima et al, 1998 ; Stoner et al, 2000 ), a possible consequence of the intense miscegenation of Afro-descendants in Brazil and in the United States. The HIV-1 epidemic was also followed by a marked spreading of JCV among urban communities ( Nali et al, 2012 ; Cayres-Vallinoto et al, 2016 ).…”

Section: The Evidences Of Human Migration Accompanied By Infectious Amentioning

confidence: 99%

Infectious Agents As Markers of Human Migration toward the Amazon Region of Brazil

et al. 2017

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Infectious agents are common companions of humans and since ancient times they follow human migration on their search for a better place to live. The study of paleomicrobiology was significantly improved in its accuracy of measurement with the constant development of better methods to detect and analyze nucleic acids. Human tissues are constantly used to trace ancient infections and the association of anthropological evidences are important to confirm the microbiological information. Infectious agents which establish human persistent infections are particularly useful to trace human migrations. In the present article, the evidence of infection by viral agents such as human T-lymphotropic virus 1, human T-lymphotropic virus 2, human herpes virus-8, JC virus, and a bacterium, Chlamydia trachomatis, was described using different methodologies for their detection. Their presence was further used as biomarkers associated with anthropological and other relevant information to trace human migration into the Amazon region of Brazil. The approach also evidenced their microbiological origin, emergence, evolution, and spreading. The information obtained confirms much of the archeological information available tracing ancient and more recent human migration into this particular geographical region. In this article, the paleomicrobiological information on the subject was summarized and reviewed.

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JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region

Cited by 4 publications

References 42 publications

Detection and analysis of variants of JC polyomavirus in urine samples from HIV-1-infected patients in China’s Zhejiang Province

Detection and analysis of variants of JC polyomavirus in urine samples from HIV-1-infected patients in China’s Zhejiang Province

The Epidemiological Impact of STIs among General and Vulnerable Populations of the Amazon Region of Brazil: 30 years of Surveillance

Infectious Agents As Markers of Human Migration toward the Amazon Region of Brazil

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