Prenatal Tobacco Exposure Shortens Telomere Length in Children

Ip, Patrick; Chung, Brian Hon Yin; Ho, Frederick Ka Wing; Chan, Godfrey Chi Fung; Deng, Wen; Wong, Wilfred Hing Sang; Lee, So Lun; Ying, Dingge; Wong, Wai Lap; Tung, Keith T. S.

doi:10.1093/ntr/ntw139

Cited by 34 publications

(29 citation statements)

References 50 publications

(41 reference statements)

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“…5 ) (Lee et al, 2017(Lee et al, , 2019. Cigarette smoke exposure also has an adverse effect on the telomere length in children (Ip et al, 2017). Air pollutants and cigarette smoke are common extrinsic inducers to evoke oxidative stress and inflammation in the airway Chandrasekaran et al, 2017), leading to the vulnerability of telomere (Von Zglinicki, 2002;Venkatachalam et al, 2017).…”

Section: Telomere Shorteningmentioning

confidence: 99%

Potential Role of Cellular Senescence in Asthma

Wang

Yang

et al. 2020

Front. Cell Dev. Biol.

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Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation. Cellular senescence not only occurs during the natural aging of normal cells, but also can be accelerated by various pathological factors. Cumulative studies have shown the role of cellular senescence in the pathogenesis of chronic lung diseases including chronic obstructive pulmonary diseases (COPD) and idiopathic pulmonary fibrosis (IPF) by promoting airway inflammation and airway remodeling. Recently, great interest has been raised in the involvement of cellular senescence in asthma. Limited but valuable data has indicated accelerating cellular senescence in asthma. This review will compile current findings regarding the underlying relationship between cellular senescence and asthma, mainly through discussing the potential mechanisms of cellular senescence in asthma, the impact of senescent cells on the pathobiology of asthma, and the efficiency and feasibility of using anti-aging therapies in asthmatic patients.

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Section: Telomere Shorteningmentioning

confidence: 99%

Potential Role of Cellular Senescence in Asthma

Wang

Yang

et al. 2020

Front. Cell Dev. Biol.

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“…Ip et al examined the relationship between prenatal tobacco exposure and telomere length in children [13*]. Telomeres are the regions of repetitive nucleotide sequences at each end of a chromosome; they protect the chromosome end from deterioration or fusion with neighboring chromosomes.…”

Section: Exposure Scenariosmentioning

confidence: 99%

“…Telomeres are the regions of repetitive nucleotide sequences at each end of a chromosome; they protect the chromosome end from deterioration or fusion with neighboring chromosomes. Telomere shortening is associated with a number of adverse health outcomes including cancer, type 2 diabetes, cardiovascular diseases, Alzheimer’s disease, and early mortality [13*]. Cigarette smoking is an established cause of telomere shortening [14].…”

Section: Exposure Scenariosmentioning

confidence: 99%

Tobacco, e-cigarettes, and child health

Peterson

Hecht

2017

Current Opinion in Pediatrics

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Purpose of the review The availability of the Children’s Health Exposure Assessment Resource funded by the National Institute of Environmental Health Sciences provides new opportunities for exploring the role of tobacco smoke exposure in causing harm to children. Findings Children of smokers are exposed to nicotine and other harmful tobacco smoke chemicals in utero as well as in their environment. This passive exposure to tobacco smoke has a variety of negative effects on children. In utero exposure to tobacco smoke causes poor birth outcomes and influences lung, cardiovascular and brain development, placing children at increased risk of a number of adverse health outcomes later in life such as obesity, behavioral problems and cardiovascular disease. Furthermore, most smokers start in their adolescence, an age of increased nicotine addiction risk. Biomarkers of tobacco exposure helps clarify the role tobacco chemicals play in influencing health both in childhood and beyond. While e-cigarettes appear to be a nicotine delivery device of reduced harm, it appears to be a gateway to the use of combustible cigarette smoking in adolescents. Summary Pediatric researchers interested in elucidating the role of tobacco smoke exposure in adverse outcomes in children should incorporate biomarkers of tobacco exposure in their studies.

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“…In addition, oxidative stress also induces fetal programming which contributes to the development of adult-onset diseases (Luo, et al, 2006) Endothelial cells of blood vessels are damaged as early as during the first month of life of children exposed to second hand smoke and these effects can be detected during the first decade of life (Das, 2003). In a population representative study to investigate the association between prenatal tobacco exposure and telomere length in children (aged under 15 years with prenatal tobacco exposure), it was found that the telomere length in children with prenatal tobacco exposure was significantly shorter than in those with no exposure (mean T/S ratio = 24.9 [SD = 8.58] in exposed vs. 28.97 [14.15] in control groups; (P = 0.02) thus, leading on to premature aging and increased health risks (Ip, et al, 2016) Thus, by this imbalance between oxidants and anti-oxidants, protection afforded to the developing fetus and fetal respiratory system by the mother is compromised, causing vulnerability to oxidative DNA damage and altering the development of the respiratory system.…”

Section: Pathogenesis Of Smoke Exposurementioning

confidence: 99%

Direct and Second Hand Cigarette Smoke Exposure and Development of Childhood Asthma

Gopal

Mukherjee

Das

2016

JEHS

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This is a comprehensive review about the role of direct and second hand cigarette smoke exposure in the development of childhood asthma. Smoking, both during pregnancy and postnatal have an adverse impact on the infant's chances of developing respiratory illness. Second hand smoke exposure has also known to cause worsening of childhood asthma with an impact on hospital admissions. Correlation between maternal second hand smoke exposure during pregnancy and development of childhood asthma has also been investigated. It is, thus essential to address this prenatally as well as postnatal by reducing smoking as well as smoke exposure.

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Prenatal Tobacco Exposure Shortens Telomere Length in Children

Cited by 34 publications

References 50 publications

Potential Role of Cellular Senescence in Asthma

Potential Role of Cellular Senescence in Asthma

Tobacco, e-cigarettes, and child health

Direct and Second Hand Cigarette Smoke Exposure and Development of Childhood Asthma

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