Global and regional lung function in cystic fibrosis measured by electrical impedance tomography

Abstract

EIT changes during forced expiration correlate with lung function parameters, clinical findings, and radiology. Regional analysis of EIT illustrates regional lung function and visualizes individual therapeutic effects. Pediatr Pulmonol. 2016;51:1191-1199. © 2016 Wiley Periodicals, Inc.

Flow‐volume loops measured with electrical impedance tomography in pediatric patients with asthma

“…Our earlier study on healthy adults showed a good correlation between EIT and spirometric pneumotachography measurements in volume, but a small deviation in flow during forced expiration maneuvers . Also in the present study, there was good correlation between spirometry and EIT for the asthmatic patients and controls ( P < 0.001 for FEV 1 , FEV 0.5 , MEF 75 , MEF 50 , and MEF 25 in all groups, except P = 0.0038, for MEF 75 in the asthmatics before BSL).…”

“…Therefore, a scaling between these two data were required. In an earlier study in healthy adults, we showed that spirometric volumes and impedance changes correlate well during spontaneous breathing and forced expiration maneuvers . In detail, this is described as: where “a” is the scaling factor from arbitrary unit [AU] to liter [L] and “b” corresponds to a shift of the ordinate.…”

“…Although the high correlation between EIT and aeration of the lung during tidal breathing is well documented, 3,4 EIT is still mainly used to provide information on lung aeration in intensive care settings to improve mechanical ventilation. [5][6][7][8] However, preliminary studies have shown a similar correlation between EIT and aeration during forced expiration maneuvers when performing spirometry [9][10][11][12][13][14][15] and during forced oscillation maneuvers. 16 This implies that EIT is also of potential value for pulmonologists, as it combines functional and regional information during pulmonary function testing.…”

Regional lung function testing in children using electrical impedance tomography

“…Nevertheless, it is one of the largest EIT studies involving human subjects for the determination of regional lung function ever performed. The few previous studies on paediatric patients are limited to 10‐20 patients; healthy children were hardly ever studied …”

A CMOS current driver with built-in common-mode signal reduction capability for EIT

“…Recent studies [1], [2] show that EIT can facilitate real time dynamic monitoring of lung aeration and improve the breathing control of both children and preterm babies by indicating areas of lung that are subject to over inflation or lung collapse. Currently, especially for preterm babies, there is no monitoring device available to detect and give early warning of respiratory failure.…”