Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case–control analysis

Abstract

Our results provide evidence that T2DM is not an independent risk factor for HOA. Concurrence of T2DM with HT, HL, and/or obesity did not change this association significantly.

Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study

“…These concordant findings were despite differences in the study population settings (primary vs secondary care), the severity of hand OA at baseline (mean baseline KLsum score 7.8 vs 21.0, respectively), and adjustment for the presence of other metabolic factors in the current study. Risk factors for hand OA could vary for different stages of the disease (52) as associations have been reported between obesity and diabetes, and incident hand OA (10,(18)(19)(20)(21), but the current work did not find an association between obesity or diabetes and incident OA over 7 years. This lack of association could be due to the relatively small numbers available in the incident analyses, the small amounts of change that were seen in KLsum score, and the number of joints with KL ≥ 2 over 7 years in this group, and because although individuals were free of radiographic OA, they had hand pain and could have had clinical or pre-radiographic OA.…”

“…However, the role that metabolic factors play in the incidence and progression of hand OA is unclear, as little longitudinal research has been undertaken. Apart from one study that did not find an association between type 2 diabetes and incident hand OA (10), and two studies that examined hyperlipidaemia and incident hand OA with differing results (11,12), most studies have focused on obesity, and conflicting findings have been reported (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). The disparity in results could be due to variations in study populations and the definitions of progression used.…”

Very High Prevalence of Frozen Shoulder in Patients With Type 1 Diabetes of ≥45 Years' Duration: The Dialong Shoulder Study

“…The report indicated a higher prevalence of diabetes mellitus in persons with hand OA than in persons without (107), but not higher prevalence of OA in persons with diabetes than diabetes-free persons. A later study of hand OA and type 2 diabetes showed no such association (109). In our study, only patients with DM1 lasting 45 years or more was included.…”

Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

“…The epidemiological relationship between T2D and OA was confirmed by different metanalysis showing the actual existence of a greater risk of developing OA in diabetic individuals . However, the strength of such an association may vary by considering the heterogeneity of age, ethnic group, duration of T2D, body weight, and osteoarthritic joint location among individuals affected …”

“…25,26 However, the strength of such an association may vary by considering the heterogeneity of age, ethnic group, duration of T2D, body weight, and osteoarthritic joint location among individuals affected. 27 Different studies demonstrated the connection between longstanding T2D and accelerated OA progression with higher rates of synovial inflammation and joint pain. 28 These associations were even more pronounced in young diabetic subjects with hand OA, which seem more prone to develop the erosive subtype of the disease.…”