Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study

Marshall, Michelle; Peat, George; Nicholls, Elaine; Myers, H.; Mamas, Mamas A.; Windt, D. van der

doi:10.1080/03009742.2018.1459831

Cited by 21 publications

(33 citation statements)

References 51 publications

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“…The compound metabolic syndrome showed a none significant tendency to increase osteoarthritis of both hips. These results are partially in line with previous studies which show that most singular components of metabolic syndrome as well as the compound metabolic syndrome have no impact on osteoarthritis of the hip joints [10,27,28], whereas other studies have shown, that prevalence of metabolic syndrome is higher in patients with osteoarthritis [29]. It has to be acknowledged, that most studies showing a positive association between metabolic syndrome or its singular components (e.g.…”

Section: Discussionsupporting

confidence: 91%

Association between metabolic syndrome and hip osteoarthritis in middle-aged men and women from the general population

Walter

Wintermeyer²,

Klinger

et al. 2020

PLoS ONE

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Objective To investigate the impact of metabolic syndrome and its components on osteoarthritis of the hip joints compared to a healthy cohort in the KORA MRI-study. Methods Randomly selected men and women from the general population were classified as having metabolic syndrome, defined as presence of central obesity plus two of the following four components: elevated blood pressure (BP), elevated fasting glucose, elevated triglycerides (TG) and low HDL-cholesterol (HDL-c), or as controls without metabolic syndrome. Therefore, each subject underwent detailed assessment of waist circumference as well as fasting glucose, systolic and diastolic BP, TG, and HDL-c concentrations as well as a full-body MR scan. MR measurements were performed on a 3 Tesla scanner (Magnetom Skyra, Siemens) including a dual-echo Dixon and a T2 SS-FSE sequence for anatomical structures. In order to quantify osteoarthritis of the hip, assessment was performed by two independent, experienced radiologists for joint gap narrowing, osteophytic lipping and subchondral changes (e.g. sclerosis, pseudocysts). Associations between metabolic syndrome components and hip degeneration were estimated by logistic regression models providing odds ratios. Results Among 354 included participants (mean age: 56.1 ± 9.2 years; 55.4% male), 119 (34%) had metabolic syndrome, while 235 (66%) were part of the control group. Except for elevated

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Section: Discussionsupporting

confidence: 91%

Association between metabolic syndrome and hip osteoarthritis in middle-aged men and women from the general population

Walter

Wintermeyer²,

Klinger

et al. 2020

PLoS ONE

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“…Risk factors which increase the chance of IPJ osteoarthritis progression in patients have been studied in the literature. We identified eight studies (seven high risk of bias) investigating potential risk factors for the progression of finger IPJ osteoarthritis [37][38][39][40][41][42][43][44]. All studies measured osteoarthritis progression radiographically, using a version of the KL classification system [45,46].…”

Section: Discussionmentioning

confidence: 99%

“…Results were largely similar when DIPJ and PIPJ osteoarthritis when assessed separately. The KL classification system [45,46] was used to measure osteoarthritis progression by all studies [37][38][39][40][41][42][43][44]49]. The KL classification system [45,46] is a sensitive method for measuring the progression of radiographic hand osteoarthritis over a 1-year time frame [20].…”

Section: Discussionmentioning

confidence: 99%

“…Eight prospective cohort studies were included [37][38][39][40][41][42][43][44] ( Table 1). Five studies included men and women [40][41][42][43][44], whilst three studies included only men [37][38][39]. The smallest study included 177 participants [37], whilst the largest study included 5560 participants [40].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Seven studies were rated as having overall high risk of bias [37][38][39][41][42][43][44], and one study was of moderate risk of bias [40] (…”

Section: Risk Of Biasmentioning

confidence: 99%

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Risk factors for the progression of finger interphalangeal joint osteoarthritis: a systematic review

et al. 2020

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Progressive hand interphalangeal joint (IPJ) osteoarthritis is associated with pain, reduced function and impaired quality of life. However, the evidence surrounding risk factors for IPJ osteoarthritis progression is unclear. Identifying risk factors for IPJ osteoarthritis progression may inform preventative strategies and early interventions to improve long-term outcomes for individuals at risk of IPJ osteoarthritis progression. The objectives of the study were to describe methods used to measure the progression of IPJ osteoarthritis and identify risk factors for IPJ osteoarthritis progression. MEDLINE, EMBASE, Scopus, and The Cochrane Library were searched from inception to 19th February 2020 (PROSPERO CRD42019121034). Eligible studies assessed potential risk factor/s associated with IPJ osteoarthritis progression. Risk of bias was assessed using a modified QUIPS Tool, and a best evidence synthesis was performed. Of eight eligible studies, all measured osteoarthritis progression radiographically, and none considered symptoms. Eighteen potential risk factors were assessed. Diabetes (adjusted mean difference between 2.06 and 7.78), and larger finger epiphyseal index in males (regression coefficient β = 0.202) and females (β = 0.325) were identified as risk factors (limited evidence). Older age in men and women showed mixed results; 13 variables were not risk factors (all limited evidence). Patients with diabetes and larger finger epiphyseal index might be at higher risk of radiographic IPJ osteoarthritis progression, though evidence is limited and studies are biased. Studies assessing symptomatic IPJ osteoarthritis progression are lacking.

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Comparison of the cardiovascular risk profile of rheumatoid arthritis versus hand osteoarthritis patients

Mathieu

Lambert²,

Fayet

et al. 2023

Rheumatol Int

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Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study

Cited by 21 publications

References 51 publications

Association between metabolic syndrome and hip osteoarthritis in middle-aged men and women from the general population

Association between metabolic syndrome and hip osteoarthritis in middle-aged men and women from the general population

Risk factors for the progression of finger interphalangeal joint osteoarthritis: a systematic review

Comparison of the cardiovascular risk profile of rheumatoid arthritis versus hand osteoarthritis patients

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