Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus

Kumarasingha, Rasika; Preston, Sarah; Yeo, Tiong-Chia; Lim, Diana S L; Tu, Chu-Lee; Palombo, Enzo A.; Shaw, Jillian M; Gasser, Robin B.; Boag, Peter R.

doi:10.1186/s13071-016-1458-9

Cited by 45 publications

(32 citation statements)

References 37 publications

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“…The narrow -spectrum compounds, like salicylanilides, substituted phenols and triclabendazole, have activity against fewer species of parasites (Tariq, 2015). Although the development of monepantel added another molecule to the antiparasitic compounds market, success in discovering new drugs has been limited (Kumarasingha et al, 2016).…”

Section: Known Anthelmintic Resistance In Ruminants and Its Diagnosismentioning

confidence: 99%

Aspects of epidemiology and control of gastrointestinal nematodes in sheep and cattle – Approaches for its sustainability

Bresciani¹,

Coelho²,

Gomes³

et al. 2017

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A B S T R A C TGastrointestinal helminthosis in ruminants cause considerable economic losses, with marked impairment of productivity of these animals, especially in poor management systems and poor parasite control programs. Infections caused by these helminths represent an obstacle to the expansion of the sheep industry. Furthermore, high parasite burdens were associated with increased mortality in calves. The recommended methods for the control of gastrointestinal helminths not always have practical applicability. We discuss important epidemiological and control aspects concerning gastrointestinal nematodes in sheep and cattle. Thus, sustainable worm control practices are recommended. Each farm has a specific situation and a management system directed to a specific parasitic infection must be adopted.Keywords: cattle, sheep, gastrointestinal helminths, epidemiology, control, sustainability. R E S U M OHelmintíases gastrintestinais em ruminantes acarretam perdas econômicas relevantes, com marcante prejuízo da produção animal, especialmente em sistemas de maneio precários e em programas de controle parasitário deficientes. Infeções causadas por esses helmintos representam um obstáculo para a expansão do mercado ovino. Ademais, altas cargas parasitárias foram associadas à elevada mortalidade em bezerros. Os métodos recomendados para o controle de helmintos gastrintestinais nem sempre apresentam aplicação prática. Nós discutimos os aspectos importantes sobre nematodes gastrintestinais em ovinos e caprinos. Sendo assim, práticas de controle sustentáveis são recomendadas. Cada propriedade possui uma situação em particular e um sistema de maneio direcionado deve ser adotado para as infecções parasitárias específicas.Palavras -chave: bovinos, ovinos, helmintos gastrintestinais, epidemiologia, controlo, sustentabilidade. 665Bresciani et al., Gastrointestinal nematodes in sheep and cattle

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Section: Known Anthelmintic Resistance In Ruminants and Its Diagnosismentioning

confidence: 99%

Aspects of epidemiology and control of gastrointestinal nematodes in sheep and cattle – Approaches for its sustainability

Bresciani¹,

Coelho²,

Gomes³

et al. 2017

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“…These plants may also posses' biological activity against significant parasites of veterinary standpoint, which could effectively be used to control ecto-and endo-parasites postscientific validation. The efficacy of plant extracts/products against endo-and ecto-parasites of animals have been reported with variable success (e.g., Chen et al, 2011;Maphosa and Masika, 2012;Martinez-Ortiz-de-Montellano et al, 2013;Mbaya and Ogwiji, 2014;Silva et al, 2014;Abbas et al, 2014Abbas et al, , 2015Abbas et al, , 2017Kumarasinghe et al, 2016). Most frequently used plants are sown either by the farmers or found self-grown, in the fields.…”

Section: Plants As Anti-parasiticsmentioning

confidence: 99%

An Overview of Plants with Acaricidal and Anthelmintic Properties

Zaman¹

2017

IJAB

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Geo-climatic and socio-economic conditions provide a favourable environment for parasitic population of livestock in Pakistan. Hard ticks (Ixodidae) and gastrointestinal nematodes pose most serious threats to livestock industry. Stackholders rely on synthetic drugs to control these parasites. Emergence of drug resistance in these parasites; however, has provoked interest in alternate of synthetic drugs. Testing of plants used in ethnoveterinary medicine for their antiparasitic activity employing standard procedures has been reported to be promising. Plants have been most frequently used for deworming purposes followed by as acaricides and insecticides; whereas, reports as to their antiprotozoal use are relatively less. Use of plants as antiparasitics is more frequent in developing countries having low accessability to the modern parasite control practices. Likewise, validation studies on the use of plants as antiparasitics have been more frequently carried out in the developing countries compared with those having livestock farming as commercial enterprise. This article presents an overview of the plants having acaricidal and anthelmintic activity, limitations as to the application of phytotherpay to control parasites and future prospects of the use of plants as antiparasitics.

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“…It has also been used in traditional herbal medicine as a diuretic and gastrointestinal disorder treatment (Hosseinzadeh et al, 2002). Studies have shown that A. graveolens acts against bacteria (Kaur and Arora, 2009), fungi (Kumarasingha et al, 2016;Vieira et al, 2019), protozoa (Sahib et al, 2014) and insects (Khani and Basavand, 2013), although for the latter group their pollen grains may be used to feed certain orders (D'Ávila et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Antihelminthic action of the Anethum graveolens essential oil on Haemonchus contortus eggs and larvae

et al. 2021

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Gastrointestinal nematodes are responsible for great economic losses in sheep raising, and their control has long been carried out almost exclusively by the administration of anthelmintics, which have led to serious resistance problems. In the search for alternative control measures, phytotherapic research is highlighted. The aim of this study was to evaluate the action of Anethum graveolens (dill) essential oil on different stages of Haemonchus contortus life cycle, as well its cytotoxicity MDBK (Madin-Darby bovine kidney) cells. H. contortus larvae and eggs were obtained from infected sheep feces, and essential oil extracted from plant seeds through the Clevenger apparatus. 9.4, 4.7, 2.35, 1.17. 0.58 and 0.29 mg/mL concentrations were evaluated. The Egg Hatch Inhibition (HI), Larval Development Inhibition (LDI) and Larval Migration Inhibition (LMI) techniques were used. Thybendazole 0.025 mg/mL in HI and Levamisole 0.02 mg/mL in the LDI and LMI tests were used as positive controls, while distilled water and a Tween 80 solution were used as positive negative controls. The inhibition results obtained for the highest oil concentration were: HI 100%, LDI 98.58% and LMI 63.7%, differing ( <0.05) from negative controls. Main A. graveolens oil components present in 95.93% of the total oil were Dihydrocarvone (39.1%), Carvone (22.24%), D-Limonene (16.84%), Apiol (10.49%) and Trans-dihydrocarvone (7.26%). Minimum A. graveolens essential oil concentrations required to inhibit 50% (IC50) of egg hatching, larval development and larval migration were 0.006 mg/mL, 2.536 mg/mL and 3.963 mg/mL, respectively. Cell viability in MDBK (Madin-Darby bovine kidney) cells, when incubated with A. graveolens essential oil, was 86% for the highest (9.4 mg/mL) and 99% for the lowest concentration (0.29 mg/mL). A. graveolens essential oil, according to the results obtained in this study, is a promising alternative in sheep gastrointestinal nematode control. ResumoOs nematoides gastrintestinais são responsáveis por grandes perdas econômicas na ovinocultura, e seu controle tem sido realizado quase exclusivamente pela administração de anti-helmínticos, que levaram a sérios problemas de resistência. Na busca de medidas alternativas de controle, destaca-se a pesquisa fitoterápica. O objetivo deste trabalho foi avaliar a ação do óleo essencial de Anethum graveolens (endro) em diferentes estágios de Haemonchus contortus, bem como testar a viabilidade celular para o óleo. Larvas e ovos de H. contortus foram obtidos de fezes de ovinos infectados e óleo essencial extraído de sementes de plantas através do aparelho de Clevenger. As concentrações avaliadas foram 9,4, 4,7, 2,35, 1,17, 0,58 e 0,29 mg/mL. Verificou-se a Inibição de eclosão dos ovos (IE), Inibição de Desenvolvimento Larval (IDL) e Inibição de Migração Larval (IML). Tiabendazol 0,025 mg/mL em IE e Levamisole 0.02 mg/mL nos testes IDL e IML foram usados como controles positivos, enquanto água destilada e uma solução Tween 80 foram usados como controles negativos. Os resultados de inibição o...

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Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus

Cited by 45 publications

References 37 publications

Aspects of epidemiology and control of gastrointestinal nematodes in sheep and cattle – Approaches for its sustainability

Aspects of epidemiology and control of gastrointestinal nematodes in sheep and cattle – Approaches for its sustainability

An Overview of Plants with Acaricidal and Anthelmintic Properties

Antihelminthic action of the Anethum graveolens essential oil on Haemonchus contortus eggs and larvae

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