Hodgkin's lymphoma as a rare variant of Richter's transformation in chronic lymphocytic leukemia: A case report and review of the literature

Janjetovic, Snjezana; Bernd, Heinz‐Wolfram; Bokemeyer, Carsten; Fiedler, Walter

doi:10.3892/mco.2016.727

Cited by 9 publications

(10 citation statements)

References 14 publications

(27 reference statements)

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“…Approximately 2-10% of patients with CLL will develop RS during the course of their disease and, in 85-90% of cases, histopathology shows aggressive DLBCL. Less frequently, CLL may progress into HL, now termed Hodgkin's variant (HV) of RS, which comprises only 10-15% of all RS cases (7)(8)(9)(10)(11). Two types of Hodgkin transformation of CLL/SLL have been described.…”

Section: Discussionmentioning

confidence: 99%

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Hodgkin Lymphoma Transformation of Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: Chance Association or Therapy-related?

Sachanas

Pangalis

Moschogiannis

et al. 2017

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The established treatment algorithms for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) are currently challenged by novel classes of drugs, with ibrutinib being one of the most effective. Published data suggest that patients with early progression under ibrutinib often emerge as having Richter's transformation (RT) with a rapidly fatal prognosis, mostly developing diffuse large B-cell lymphoma (DLBCL). In this respect, it is known that RT to large DLBCL occurs in about 5% of patients with CLL during the disease course and less frequently to Hodgkin lymphoma (HL). Here, we report a patient with CLL who presented with HL transformation while still receiving therapy with ibrutinib stressing the need for clinical vigilance in any case with persisting or enlarging lymph nodes during treatment with this agent, as prompt modification of therapy is most important.

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Section: Discussionmentioning

confidence: 99%

“…CLL/SLL transformation into HL is observed in only about 0.5 % of patients and, until now, less than 100 cases have been reported (9)(10)(11).…”

Section: Abstract the Established Treatment Algorithms For Chronic Lmentioning

confidence: 99%

Hodgkin Lymphoma Transformation of Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: Chance Association or Therapy-related?

Sachanas

Pangalis

Moschogiannis

et al. 2017

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“…Leukemia is a highly heterogeneous and aggressive disease of the hematological system with strikingly variable clinical courses . In China, the overall number of patients suffering from leukemia has reached 4 million with an increase of about 50 thousand patients each year.…”

Section: Introductionmentioning

confidence: 99%

“…Leukemia is a highly heterogeneous and aggressive disease of the hematological system with strikingly variable clinical courses. 1 In China, the overall number of patients suffering from leukemia has reached 4 million with an increase of about 50 thousand patients each year. To date, the exact etiology of acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) is still elusive, which hinders the diagnosis and treatment of leukemia.…”

Section: Introductionmentioning

confidence: 99%

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Overlapped differentially expressed genes between acute lymphoblastic leukemia and chronic lymphocytic leukemia revealed potential key genes and pathways involved in leukemia

Zhang

Yin

et al. 2019

J of Cellular Biochemistry

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Common differentially expressed genes (DEGs) in acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) might play critical roles in the pathogenesis and process of leukemia. We collected RNA sequencing (RNA‐seq) data of human CLL, ALL samples, and normal peripheral blood CD19+ B cells as well as thymus samples, and analyzed similarities and differences between their transcriptomes using Cuffdiff2, DESeq, and edgeR. Compared with the RNA‐seq data of normal peripheral blood CD19+ B cells and thymus samples, there were a large number of DEGs in ALL and CLL. DEGs in ALL and CLL not only have their distinguished features but also have a similar pattern. To figure out the common DEGs between CLL and ALL, we further identified 26 overlapped genes between CLL and ALL, among which 10 genes showed similar expression variation profiles whereas 16 genes showed opposite variation. The expression levels of 10 genes (SCML4, TNF‐α, CD1C, FGFR1, MYO7B, DUSP1, PAP1GAP, MAN1C1, SLFN5, and CD8A) among the 26 genes were further confirmed by experiments, which was consistent with the results obtained by analyzing the RNA‐seq data. The current study contributes to better understanding the pathophysiology of leukemia and unearthing novel potential prognostic markers and therapeutic targets of leukemia.

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Hodgkin's variant of Richter transformation during ibrutinib therapy: A case report and review of the literature

Afonso

Gomes

Pereira

et al. 2022

Clinical Case Reports

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Hodgkin's lymphoma as a rare variant of Richter's transformation in chronic lymphocytic leukemia: A case report and review of the literature

Cited by 9 publications

References 14 publications

Hodgkin Lymphoma Transformation of Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: Chance Association or Therapy-related?

Hodgkin Lymphoma Transformation of Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: Chance Association or Therapy-related?

Overlapped differentially expressed genes between acute lymphoblastic leukemia and chronic lymphocytic leukemia revealed potential key genes and pathways involved in leukemia

Hodgkin's variant of Richter transformation during ibrutinib therapy: A case report and review of the literature

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