Frequency of Fluoride Dentifrice Use and Caries Lesions Inhibition and Repair

Abstract

The clinical relevance of the frequency of fluoride dentifrice (FD) use on enamel caries is based on evidence. However, the relative effect of FD on reduction of demineralization or enhancement of remineralization is unknown and the effect of frequency on root dentine caries has not been explored. The aim of this double-blind, crossover, in situ study, which was conducted in 4 phases of 14 days each, was to evaluate the relationship between the frequency of FD use and enamel and root dentine de- and remineralization. Eighteen volunteers wore palatal appliances containing enamel and root dentine slabs, either sound or carious. Biofilm accumulation on the slab surface was allowed, and 20% sucrose solution was dripped 3 or 8 times per day on the carious and sound slabs, respectively. Volunteers used FD (1,100 μg F/g) in the frequencies 0 (fluoride-placebo dentifrice), 1, 2 and 3 times per day. The demineralization and remineralization that occurred in sound or carious slabs was estimated by the percentage of surface hardness loss (%SHL) or recovery (%SHR). Loosely (CaF₂) and firmly (FAp) bound fluoride concentrations were also determined. The relationship between the variables was analyzed by linear regression. The %SHL, CaF₂ and FAp concentrations were a function of the frequency of FD use for enamel and dentine, but the %SHR was a function of the frequency of FD use only for enamel (p < 0.05). The results suggest that demineralization in enamel and root dentine is reduced in proportion to the frequency of FD use, but for remineralization the effect of the frequency of FD use was relevant only to enamel.

Fluorosis dental en niños de 12 y 15 años del municipio de Andes Dental fluorosis in children

“…Con base en lo expuesto, se requiere que en las acciones de promoción y prevención, se incluyan procesos educativos orientados a capacitar a la población en el manejo adecuado de fluoruros tópicos, de manera particular en lo relacionado con el uso de las cremas dentales fluoruradas en niños con edades en riesgo de fluorosis dental, con base en la evidencia científica actual (37)(38)(39)(40)(41)(42).…”

Root dentine demineralisation according to frequency of sucrose exposure using high‐fluoride dentifrice

“…The frequency of toothbrushing used in this study was based on previous studies and in the fact that the higher the frequency of F‐dentifrice use, the lower the dentine demineralisation, showing that frequency of F‐dentifrice use is important to interfere with the development of root dentine caries . Additionally, only 5000 ppm F‐dentifrice was used, and no comparison could be made to a dentifrice with lower fluoride content since it would increase the number of experimental phases and would be unfeasible to the volunteers.…”

Clinical Diagnosis of Dental Caries in the 21st Century: Introductory Paper – ORCA Saturday Afternoon Symposium, 2016

“…The mineral loss caused by metabolic activities in the dental biofilm is to a certain extent compensated by the mineral gain promoted by saliva and enhanced by fluorides in the oral environment [Larsen and Bruun, 1994;Fejerskov and Clarkson, 1996;Ten Cate et al, 2008;Cury and Tenuta, 2014;Nóbrega et al, 2016]. The disease may manifest itself clinically as caries lesions at different stages of development and rates of progression [Carvalho, 2014;Carvalho et al, 2016;Fejerskov et al, 2015].…”