Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process

Abstract

42A modified tri-axial electrospinning process was developed for the generation of a

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

“…This is in line with current trends which encourage the provision of efficient outpatients' services which can be controlled digitally and remotely (McLean et al, 2013). The demand for versatile and adjustable manufacturing technologies that are capable of overcoming the rigidity and the high cost of traditional manufacturing methods of individualised oral tablets for a limited number of patients is also rising (Yang et al, 2016;Yu et al, 2015). Unlike conventional tablet compression methods, 3D Printing technologies are capable of fabricating small number of dosage forms, reduce the number of steps and experienced operators involved in manufacturing, and eliminate the need for designated and expensive facilities (Skowyra et al, 2015).…”

AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

“…Solventbased electrospinning has been found to be an excellent method also for the preparation of solid dispersions due to the fast and, thus, very efficient amorphization of the drug enclosed in the fibers owing a large surface area Yu et al, 2009). Although various modifications have been published in respect to the ES setup related mostly to the spinneret (e.g., needleless (Molnár and Nagy, 2016), side-by-side or multiaxial electrospinning (Illangakoon et al, 2015;Yang et al, 2016;Yu et al, 2015)), the challenge of increasing the productivity of ES could not have been addressed considering the high output of other fiber formation techniques such as melt blowing (Balogh et al, 2015b). Recent efforts for scaling up of ES combine the electrostatic field with another fiber formation force such as centrifugal force at low (Lomov and Molnár, 2015) and high (Nagy et al, 2015) frequencies, or a blow of air (Balogh et al, 2015c).…”

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

“…1a), except that more complex spinnerets are required. The introduction of un-spinnable fluids into the process can greatly expand the range of novel functional nanomaterials which can be produced [28]. There are only slightly over 100 polymers which have filament-forming properties in electrospinning, and even these often can only be processed in a very narrow concentration window [53].…”

“…A modified tri-axial process focused on the exploitation of un-spinnable liquids has also been reported [28]. These might comprise solvents, small molecule solutions, emulsions and suspensions, and should lead to a range of novel structures.…”

“…These would differ significantly from the nanoparticle-based depots which have mainly been explored to date. In the cases of coaxial and tri-axial electrospinning, it is possible to run these with only one of the working fluids being electrospinnable alone [28,29]. In standard coaxial electrospinning, the sheath fluid must be electrospinnable to support the electrospinning process and the formation of core-shell structures [30].…”