Efficacy of an ethanol/guar/triclosan/glycerine gel on bacteria and yeast loads in canine pododermatitis: a pilot study

Ortalda, C.; Noli, Chiara; Cena, Tiziana

doi:10.1111/jsap.12446

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…A variety of non‐azole treatments for MAD have been reported. In an uncontrolled study, 20 dogs with pododermatitis were treated with a gel containing ethanol, triclosan and glycerine (PawCare ® ) . The authors found that Malassezia counts estimated immediately following application were significantly decreased with the conclusion that the reduction was attributed to mechanical cleansing and possibly the ingredient triclosan.…”

Section: Discussionmentioning

confidence: 99%

“…In an uncontrolled study, 20 dogs with pododermatitis were treated with a gel containing ethanol, triclosan and glycerine (PawCare â ). 25 The authors found that Malassezia counts estimated immediately following application were significantly decreased with the conclusion that the reduction was attributed to mechanical cleansing and possibly the ingredient triclosan. In a 30 day, singleblinded study, ten dogs received an oral azole plus topical chlorhexidine compared with 20 dogs that were treated with a topical non-azole treatment only (Malacalm â containing mixed herbal oils).…”

Section: Discussionmentioning

confidence: 99%

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A novel non‐azole topical treatment reducesMalassezianumbers and associated dermatitis: a short term prospective, randomized, blinded and placebo‐controlled trial in naturally infected dogs

Sjöström¹,

Mellor²,

Bergvall

2017

Veterinary Dermatology

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Background -Malassezia yeast overgrowth on the skin is a common and often recurrent cause of dermatitis in dogs; it can be an exacerbating factor of atopic dermatitis. Anti-fungal drugs have been a standard treatment, but there is some concern that resistance may be evolving in a spectrum of Malassezia species. Safe, efficient and easy-to-use alternatives are needed.Objectives -To assess if a commercially available topical non-azole solution applied to paws affected by Malassezia-associated dermatitis (MAD), could ameliorate Malassezia numbers and associated signs over a short term (14 day) trial. Animals -Eighteen dogs with MAD affecting at least two paws.Methods -The study design was prospective, randomized, blinded and placebo-controlled, using a split-body protocol. Dogs were treated once daily with the test solution on one paw and placebo on the other. Dogs were examined at days 0 and 14 AE 3. The primary end-point was Malassezia numbers assessed cytologically. Secondary end-points were clinical scores for lesion severity and pruritus as assessed by a pruritus Visual Analog Scale (PVAS). Owner compliance and adverse effects were assessed.Results -There was a statistically significant reduction in Malassezia numbers and clinical scores for paws treated with the test solution versus placebo. No statistical difference in PVAS was found.Conclusion -Daily topical application of the test solution was effective in reducing the Malassezia burden, as well as improving clinical scores in dogs with MAD of the paws. No adverse effects were reported and owners described the product as either "easy" or "very easy" to use.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A novel non‐azole topical treatment reducesMalassezianumbers and associated dermatitis: a short term prospective, randomized, blinded and placebo‐controlled trial in naturally infected dogs

Sjöström¹,

Mellor²,

Bergvall

2017

Veterinary Dermatology

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Evaluation of the effect of a lysozyme-chitosan sugar complex (LYZOX) and decanoic acid spray on local lesions of nine dogs suspected of Malassezia dermatitis

真紀子¹,

宏紀²,

陽平³

et al. 2019

Jpn J Vet Dermatol

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Malassezia Dermatitis is a common skin disease in dogs and likely to recur. Conventionally, azole-based antifungals have been used systemically or topically, however their use has been associated with problems of drug resistance and hepatotoxicity, and the shampoo therapy can be very difficult for some patients and owners (at home). There is a skin conditioning spray product which is used mainly by human care facilities which contains D-LYZOX as the chief active ingredient. We evaluated its clinical effectiveness against local lesions on nine dogs with suspected Malassezia Dermatitis, applying it twice a day for three weeks. One case had mild erythema at the start of treatment, but natural recovery occurred immediately. The dermatitis severity score and PVAS of the spray-treated dogs significantly decreased (P<0.01). The counts of Malassezia spp. in the lesions were lower, but the results were not statistically significant. In order to verify the contribution of the anti-inflammatory property of this formulation to the improvement of the dermatitis severity score and PVAS of the cases, we examined the effects of D-LYZOX on neutrophil adhesion as an in vitro parameter of inflammatory reaction. D-LYZOX inhibited lipopolysaccharide-induced adhesion of neutrophils obtained from a normal dog, suggesting the anti-inflammatory activity of D-LYZOX. These results suggest that this spray formulation containing D-LYZOX can improve the PVAS and dermatitis severity score of suspected local Malassezia dermatitis in dogs. We also discussed the need to clarify these clinical effects and their association with the suppression of neutrophil function.

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Clinical manifestation and methods of treatment of pododermatitis in dogs

Yevtushenko

Bilyi

Tsymerman

et al. 2021

Scientific Horizons

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This paper provides data on the clinical signs of pododermatitis in dogs and also investigates effective treatment regimens. The urgency of the stated problem is due to the growing incidence of pododermatitis in dogs, its polyetiological nature, which requires a multifaceted approach to diagnostics and the introduction of effective treatments methods. Thereby, the purpose of the study was to investigate the clinical manifestations of skin diseases of the distal extremities in dogs and to determine the efficacy of complex therapy of pododermatitis. The studies were based on clinical research methods in dermatology, parasitological (skin scraping), bacteriological, and mycological (seeding on nutrient media with subsequent isolation of the pathogen) surveys. Based on the findings of the study, the absolute number of cases revealed lesions of 2 paws (53.3%), much less often – all 4 limbs (26.7%). It was found that mainly localisation of superficial skin lesions was found in 56.2% in the area of the interdigital space and 43.7% of cases – only on the plantar surface of the pastern (metatarsus), rarely – inflammation of the claw phalanx (31.2%). The main clinical signs of dermatitis of the distal extremities in dogs were erosive and ulcerative inflammation, alopecia, papules and pustules filled with purulent exudate, erythematous inflammation, haemorrhage, areas of lichenification. Studies on the treatment of dogs with pododermatitis caused by Staphylococcus intermedius, Demodex canis and Malassezia pachydermatis have shown the following: introduction of drugs Bravecto, Cefuroxime, Orungal, Apoquel and Derinat increased the efficacy of therapy in animals of the experimental group, as compared with the control (from 28.6% to 66.7%), reducing the duration of treatment to 21 days (p˂0.01) and extending the remission period to an average of 185 days (p˂0.01). The prospect of further research is the unification of clinical, morphological, and biochemical blood parameters as diagnostic criteria for pododermatitis in dogs

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Efficacy of an ethanol/guar/triclosan/glycerine gel on bacteria and yeast loads in canine pododermatitis: a pilot study

Abstract: The findings of the present study support the use of PawCare® gel to decrease bacterial and yeast loads in dogs affected by chronic diseases involving the inter-digital spaces.

Cited by 3 publications

References 13 publications

A novel non‐azole topical treatment reducesMalassezianumbers and associated dermatitis: a short term prospective, randomized, blinded and placebo‐controlled trial in naturally infected dogs

A novel non‐azole topical treatment reducesMalassezianumbers and associated dermatitis: a short term prospective, randomized, blinded and placebo‐controlled trial in naturally infected dogs

Evaluation of the effect of a lysozyme-chitosan sugar complex (LYZOX) and decanoic acid spray on local lesions of nine dogs suspected of Malassezia dermatitis

Clinical manifestation and methods of treatment of pododermatitis in dogs

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