Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder

Młyniec, Katarzyna; Trojan, Ewa; Ślusarczyk, Joanna; Głombik, Katarzyna; Basta‐Kaim, Agnieszka; Budziszewska, Bogusława; Skrzeszewski, Jakub; Siwek, Agata; Holst, Birgitte; Nowak, Gabriel

doi:10.1016/j.jneuroim.2015.12.001

Cited by 16 publications

(12 citation statements)

References 48 publications

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“…An increase in plasma globulin concentration with Zn supplementation was also observed in lactating Friesian cows(Ramuluet al 2015). According toBonaventura et al (2015),Brazão et al(2015),Młyniec et al (2015),Ramulu et al (2015),Rosenkranz et al (2015) andSchafer et al (2015) use of vaccine and Zn promotes immune system and increased level of IgG and IgM. But increase of IgE in the present study might be due toadjuvant in FMD vaccine.…”

mentioning

confidence: 50%

The Effect of Used Immunostimulating Drugs with FMD Vaccine on Immunoglobulins in Sheep

Abdullah¹,

Başbuğan

2020

Van Veterinary Journal

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In this study, the effect of used immunostimulating drugs with FMD vaccine on immunoglobulins was aimed to investigate in sheep. For this purpose 40 healthy sheep were divided into 4 groups. Blood and serum samples were taken from all animals from 0 days before the study. Blood samples were measured immediately, and IgA, IgG, IgM, IgE and Zn values from biochemical parameters were stored for measurement. Group I was applied only FMD vaccine, group II Levamisole with the FMD vaccine, group III Zinc with FMD vaccine and the last group IV AD3E was applied with FMD vaccine. After 21 days, blood and serum samples from all groups were taken again and hematologic and IgA, IgG, IgM, IgE and Zn values were compared according to the values of day 0. No statistical difference was found between the groups except for PLT in hematological parameters (p> 0, 05) when compared to pre-vaccination and post-vaccination. In groups II and III there was a significant increase in PLT levels. Biochemical analysis showed IgA, IgG, IgM and IgE levels to be higher in IgG (p <0, 05) and IgE (p <0,001) in groups II and III when levels compared to before vaccination. There were statistically significant increases in IgM (p <0.05) in group IV.

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The Effect of Used Immunostimulating Drugs with FMD Vaccine on Immunoglobulins in Sheep

Abdullah¹,

Başbuğan

2020

Van Veterinary Journal

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“…It is reported that zinc-deficient diet in mice or rats leads to a lower expression of the GPR39 receptor in both hippocampus and frontal cortex, leading to depressive-like symptoms [22,75]. What's more, depressivelike behavior in GPR39 knockout (KO) animals with immune response presented similar to that observed in depressive disorder [45].…”

Section: Zinc and Cns Pathologymentioning

confidence: 88%

“…Zinc is not only important for DNA repair and protein synthesis which influences cell division and differentiation, but also an ionic signal [13]. Zinc deficiency has been shown to contribute to alterations in behavior, abnormal neurological development and diseases as well [22,26,27,45]. On the other hand, overabundant levels of zinc can also be cytotoxic, resulting in neuron apoptosis [46][47][48] and neuronal death [49,50].…”

Section: Zinc In the Central Nervous System (Cns)mentioning

confidence: 99%

“…It is found in the animal studies that changes in Zn homeostasis caused by acute Zn depletion is associated with impaired spatial learning [45,46,78,79], whereas developmental Zn deficiency results in working memory deficits [80,81] as well as mood disorder. Based on preclinical studies, deficiency of zinc elements can lead to neurodegenerative processes and, by association, learning and memory impairments [77].…”

Section: Zinc and Cns Pathologymentioning

confidence: 99%

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The Role of Zinc in Mood Disorders

Piao¹,

Cong²,

Lu³

et al. 2018

Neuropsychiatry

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Mood disorders have many forms, from anxiety attacks, depression, Obsessive Compulsive Disorder (OCD) to Post Traumatic Disorder (PTSD). Recently, many studies have shown that zinc may act as a crucial neuromodulator in glutamatergic and GABAergic balance. What's more, growing evidences considered that zinc be a trait marker of mood disorder. It was reported that zinc deficiency induces depression, while supplementing with this mineral improved mood as well as cognitive function. In this present review, the links of zinc in the mood disorder and zinc in the Alzheimer's disease were systemically reviewed. It may be helpful for zinc applicantion in clinical thus address zinc as a new target of research for therapy.

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“…Dietary zinc deficiency-induced depression-like behavior with concomitant upregulation of the NMDAR [27] and oxidative as well as inflammatory parameters (IL-1 α , IL-1 β ) were generally enhanced in the tissue (serum, prefrontal cortex, and hippocampus) of the zinc deprived rats [169]. Also the study of GPR39 knockout mice, which display depressive-like behavior, showed immune malfunction: reduced thymus weight, reduced cell viability of splenocytes and reduced proliferative response of splenocytes [172]. Further studies are needed to elucidate changes within the immune system of GPR39 knockout mice as well as effects of antidepressants on zinc deficiency-induced and GPR39-knockout-induced immune alterations, that may be linked to neural plasticity events.…”

Section: Link To Neural Plasticitymentioning

confidence: 99%

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

et al. 2017

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Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.

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Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder

Cited by 16 publications

References 48 publications

The Effect of Used Immunostimulating Drugs with FMD Vaccine on Immunoglobulins in Sheep

The Effect of Used Immunostimulating Drugs with FMD Vaccine on Immunoglobulins in Sheep

The Role of Zinc in Mood Disorders

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

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