The Effect of Used Immunostimulating Drugs with FMD Vaccine on Immunoglobulins in Sheep

Abstract

In this study, the effect of used immunostimulating drugs with FMD vaccine on immunoglobulins was aimed to investigate in sheep. For this purpose 40 healthy sheep were divided into 4 groups. Blood and serum samples were taken from all animals from 0 days before the study. Blood samples were measured immediately, and IgA, IgG, IgM, IgE and Zn values from biochemical parameters were stored for measurement. Group I was applied only FMD vaccine, group II Levamisole with the FMD vaccine, group III Zinc with FMD vaccine and the last group IV AD3E was applied with FMD vaccine. After 21 days, blood and serum samples from all groups were taken again and hematologic and IgA, IgG, IgM, IgE and Zn values were compared according to the values of day 0. No statistical difference was found between the groups except for PLT in hematological parameters (p> 0, 05) when compared to pre-vaccination and post-vaccination. In groups II and III there was a significant increase in PLT levels. Biochemical analysis showed IgA, IgG, IgM and IgE levels to be higher in IgG (p <0, 05) and IgE (p <0,001) in groups II and III when levels compared to before vaccination. There were statistically significant increases in IgM (p <0.05) in group IV.

Effect of Some Immunomodulators Use Together with PPR Vaccine on Immune system in Morkaraman Sheep

“…In addition, in terms of globulin values, there has also significant difference (P<0.01). These data obtained show that LMS strengthens the immune system by causing an increase in Ig levels such as IgG and IgM and this time are in accordance with the reports of Abdullah and Basbugan (2020).…”

“…The studies on levamisole administration have shown an overall increase in Ig levels. Abdullah and Basbugan (2020) showed that IgM levels in sheep increased but it was not statistically significant, IgG levels, on the other hand, increased both numerically and gave a statistically significant result. In this study, it was determined that there was a numerical tendency to increase in IgG values within the Group C (P>0.05), and a significant numerical increase was observed (P˂0.01) in the group-based general evaluation compared to the Group F. Comparing the IgM data of the Group C and F, the difference on the 7 th day was statistically significant (P<0.01), and the comparison of evaluations of group-based regarding the Group C and F indicated that there was a differences between them (P˂0.05).…”

“…Levamisole is an immunomodulator and its immunostimulants properties become apparent and prominent when used at a repetitive dose of 2.5 mg/kg before vaccination in different animal species (Stelletta et al, 2004). Abdullah and Basbugan (2020) found that the number of WBC decreased in sheep LMS group, Rashid and Yuksek (2019) stated that a statistically significant decrease was observed in the numbers of WBC and LYM in the group in which LMS was used with the enterotoxemia vaccine in sheep. In this study, when the number of WBC within the Group C was compared between the days, it was determined that there was no statistically significant difference (P>0.05), but a numerical increase was found in WBC count.…”

Levamizol Uygulanmasının Şarbon Hastalığına Karşı Aşılanmış Sığırlarda Bağışıklık Sistemi Üzerine Etkileri

“…The amount of IgG in serum of the cattle groups (µg/mL) Those with different letters in the same row in the range of P<0.05 were found to be statistically significant It is thought that the increase in monocytes in the levamisolevaccine group could be due to the stimulating effect of levamisole on macrophages for antigens Abdullah and Başbuğan (2020). reported that the FMD vaccine in combination with 5 mg/kg levamisole decreased the number of monocytes.…”