Periodontal therapy as adjunctive treatment for gastric <i>Helicobacter pylori</i> infection

Ren, Qian; Yan, Xiang; Zhou, Yongning; Li, Wei Xin

doi:10.1002/14651858.cd009477.pub2

Cited by 25 publications

(18 citation statements)

References 48 publications

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“…With respect to the association between H. pylori infection and periodontitis, recent meta-analyses showed that H. pylori detection in the oral cavity has a positive association with the prevalence of periodontal disease (Wei et al, 2019;Liu et al, 2020). Periodontal treatment has been shown to be effective in reducing the levels of H. pylori in the oral cavity and stomach (Zaric et al, 2009;Ren et al, 2016). The presence of H. pylori in the oral cavity is also more frequent in seropositive subjects (Fernandez-Tilapa et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Our results are in line with these, in that periodontitis was found to be associated with the risk of H. pylori seropositivity (H. pylori infection) (OR = 1.271, 95% CI = 1.177-1.372) (Table 4). Furthermore, periodontal therapy could not only reduce the presence of H. pylori in the oral cavity but also prevent the recurrence of H. pylori in the stomach, according to several studies (Zaric et al, 2009;Bouziane et al, 2012;Ren et al, 2016). Although periodontitis could not directly induce or be initiated by the H. pylori infection, all the above studies demonstrated the importance of periodontal health for the prevention of H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

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Periodontitis, Helicobacter pylori infection, and gastrointestinal tract cancer mortality

Sung

Lin

Huang

et al. 2022

J Clinic Periodontology

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Aim: Periodontitis has been proposed to lead to Helicobacter pylori infection, which could cause many gastrointestinal tract cancers. This study aimed to determine the association or otherwise between periodontitis and survival outcomes in individuals with respect to H. pylori infection. Materials and Methods:The study population comprised 4955 subjects aged 20-90 who had received both periodontal examination and H. pylori serum test in the Third National Health and Nutrition Examination Survey (NHANES III) database. Logistic regression models were used to analyse the association between periodontitis and H. pylori seropositivity (H. pylori infection). Survival analysis was performed using the NHANES III linked to mortality data. Cox proportional hazard regression was carried out to investigate the association between periodontitis and gastrointestinal tract cancer mortality in individuals with/without H. pylori infection.Results: Compared to periodontal health, periodontitis was significantly associated with increased odds of H. pylori infection (OR = 1.271, 95% CI = 1.177-1.372). Periodontitis significantly increased the mortality risk from all causes (HR = 1.574, 95%

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Periodontitis, Helicobacter pylori infection, and gastrointestinal tract cancer mortality

Sung

Lin

Huang

et al. 2022

J Clinic Periodontology

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“…In a meta-analysis of seven randomized controlled trials (RCTs), including 691 participants, periodontal treatment combined with eradication treatment increased the rate of gastric HP eradication compared with eradication therapy alone. 39 In another meta-analysis, eradication treatment is more effective in the recurrence of gastric HP, combined with periodontal debridement than alone. 40 Gastric HP eradication occurred at a lower rate compared with the present study (87.4 vs. 100%), 3 months after triple treatment without periodontal therapy, in patients who were HP (+) in the stomach and HP (−) in the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and Helicobacter pylori Infection: Eradication and Periodontal Therapy Combination

et al. 2021

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Objectives This study was aimed to assess (1) the prevalence of salivary and gastric Helicobacter pylori (HP) infection in patients with and without periodontitis, (2) the prevalence of HP infection in patients with periodontitis according to its clinical classification, (3) the effect of periodontitis treatment in patients with or without gastric HP infection, and (4) if gastric HP eradication in combination with periodontitis treatment influences periodontitis clinical outcome. Materials and Methods Thirty-three adults with periodontitis treated by quadrant scaling and root planning (QSRP). The simplified plaque index (PI), bleeding on probing index (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were assessed pretreatment and 3 months of posttreatment. The patients were tested for oral and gastric HP. Gastric HP (+) patients received eradication therapy. A control group of 32 periodontically healthy volunteers was tested for oral and gastric HP. Saliva samples were evaluated by real-time polymerase chain reaction (rtPCR); gastric HP was detected by urea breath test (UBT). Statistical Analysis Normality of variables assessed by the Kolmogorov–Smirnov test, while the differences of pre- and post-treatment were analyzed by paired samples t-test. Differences between subgroups were compared by a Student’s t-test or a Mann–Whitney U-test. Comparisons of nominal variables were made by Pearson’s Chi-square test. Results No saliva samples were positive for HP. Gastric HP was detected in six patients with periodontitis and seven controls (p > 0.05). HP infection affected patients with higher disease stages and grades. All HP (+) patients underwent successful eradication treatment. All clinical periodontitis indices improved following QSRP. HP (+) patients who received QSRP as adjunctive to eradication treatment showed improvement in BOP (p < 0.001), PI (p < 0.013), and CAL (p < 0.004) compared with HP (−) patients who received QSRP alone. Conclusion Periodontitis was not associated with gastric HP infection. Saliva was not a gastric HP supply reservoir. Gastric HP infection was associated with advanced stages and degrees of periodontitis. Although all periodontal clinical markers improved after QSRP, BOP, PI, and CAL, they were further improved when combined with eradication treatment. Periodontal evaluation and treatment combined with HP eradication are recommended in patients with HP gastric infection.

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“… 13 Recent several meta-analyses report a similar conclusion regarding oral cavity and stomach. 14 , 15 , 16 , 17 The total participants involved in the above meta-analyses are more than 20 000 individuals ( Table 1 ).…”

Section: The Close Relationship Between Periodontal Health and mentioning

confidence: 99%

Are the view of Helicobacter pylori colonized in the oral cavity an illusion?

Yee¹

2017

Exp Mol Med

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Urea breath test (UBT), as a leading preferred non-invasive diagnostic technology, but may not be able to detect oral H. pylori. With negative results of UBT, the patient may have an oral infection. On the basis of the fact of success, eradication rate may increase by 21% in the 95% Cl range after the elimination of oral H. pylori, the author believes oral H. pylori does exist and the oral cavity is the second colonized site aside its primary site of the stomach. H. pylori migrated out of Africa along with its human host circa 60 000 years ago; they are not lives in stomach only. In this review article, evidence established in recent years studies with use more appropriate technology had been listed and discussed. The author considers the oral cavity is a black hole for H. pylori infection that significant effective on gastroenterology and another medical field. The role of the oral cavity as the source of H. pylori infection is so controvert in past years. It seems like a human being having a second-time face to discover H. pylori in the history.

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Periodontal therapy as adjunctive treatment for gastric Helicobacter pylori infection

Cited by 25 publications

References 48 publications

Periodontitis, Helicobacter pylori infection, and gastrointestinal tract cancer mortality

Periodontitis, Helicobacter pylori infection, and gastrointestinal tract cancer mortality

Periodontitis and Helicobacter pylori Infection: Eradication and Periodontal Therapy Combination

Are the view of Helicobacter pylori colonized in the oral cavity an illusion?

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