Are the view of Helicobacter pylori colonized in the oral cavity an illusion?

Abstract

Urea breath test (UBT), as a leading preferred non-invasive diagnostic technology, but may not be able to detect oral H. pylori. With negative results of UBT, the patient may have an oral infection. On the basis of the fact of success, eradication rate may increase by 21% in the 95% Cl range after the elimination of oral H. pylori, the author believes oral H. pylori does exist and the oral cavity is the second colonized site aside its primary site of the stomach. H. pylori migrated out of Africa along with its human host circa 60 000 years ago; they are not lives in stomach only. In this review article, evidence established in recent years studies with use more appropriate technology had been listed and discussed. The author considers the oral cavity is a black hole for H. pylori infection that significant effective on gastroenterology and another medical field. The role of the oral cavity as the source of H. pylori infection is so controvert in past years. It seems like a human being having a second-time face to discover H. pylori in the history.

Diagnostic reliability of nested PCR depends on the primer design and threshold abundance ofHelicobacter pyloriin biopsy, stool, and saliva samples

“…These data again emphasized the specificity of nested PCR because more than 500 different bacterial species are present in saliva . The oral cavity is considered to be as suitable a H pylori reservoir as the stomach in adults as well as in the case of inflamed teeth (pulp) in children, but this is still controversial issue . The identity or variability of the H pylori population can be recognized according to differences in DNA sequence.…”

“…53 The oral cavity is considered to be as suitable a H pylori reservoir as the stomach in adults 9 as well as in the case of inflamed teeth (pulp) in children, 10 but this is still controversial issue. 6,54 The identity or variability of the H pylori population can be recognized according to differences in DNA sequence. The sequence comparisons showed that identical strains populated the stomach and oral cavities also present in stool in only two patients (Table S1; samples 1,17).…”

Diagnosis of Helicobacter pylori infection

“…18 An infection of the oral cavity, which was reported to lead to unsuccessful eradication, could not be detected by UBT. 19 Finally, a large cross-sectional study conducted by Eisdorfer et al 20 showed UBT quantitative differences in the results, not only between men and women, but also according to factors which can be modified (eg, body mass index BMI, smoking), and others which cannot (eg, age) as well as the socioeconomic status. In addition, Suki et al 21 demonstrated a positive association between H. pylori infection and increased BMI (especially in patient groups with obesity).…”

“…An infection of the oral cavity, which was reported to lead to unsuccessful eradication, could not be detected by UBT …”

Autoantibodies to a specific peptide epitope of human Hsp60 (ATVLA) with homology to Helicobacter pylori HspB in H. pylori‐infected patients

“…Helicobacter pylori infection, which can be initiated by colonization of oral cavity and then gastric mucosa may become chronic and can destroy the host gastric tissue progressively . Helicobacter pylori have developed several strategies to diminish the efficiency of innate and specific adaptive immune responses .…”