Periodontitis, <i>Helicobacter pylori</i> infection, and gastrointestinal tract cancer mortality

Sung, Cheng‐En; Lin, Fu‐Gong; Huang, Ren‐Yeong; Fang, Wen‐Hui; Cheng, Wan‐Chien; Tsai, Yi‐Wen Cathy; Chen, Wei‐Liang

doi:10.1111/jcpe.13590

Cited by 20 publications

(14 citation statements)

References 60 publications

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“…In the people with CVD, higher all-cause mortality was observed in individuals with moderate/severe periodontitis. The increase of all-cause mortality by periodontitis has been reported in healthy people, 23 individuals with H. pylori infection, 25 and patients with stage 3-5 chronic kidney disease. 26 Periodontitis was associated with higher all-cause mortality in cirrhosis patients, 27 and patients undergoing hemodialysis, 28 but not after adjustments for confounders.…”

Section: Discussionmentioning

confidence: 97%

Association between periodontitis and mortality of patients with cardiovascular diseases: A cohort study based on NHANES

Chen

Song

et al. 2023

Journal of Periodontology

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BackgroundThe association between periodontitis and cardiovascular disease (CVD) has been widely explored, but little is known about the effect of periodontitis on the mortality of CVD patients. This study aims to clarify the effect of periodontitis on all‐cause and cause‐specific mortality of CVD patients.MethodsWe included 2,135 individuals with CVD from the National Health and Nutrition Examination Survey. Mortality data were ascertained by linkage to National Death Index records through 31 December 2019. We used Cox proportional hazards models for all‐cause mortality and competing risk models for CVD and cancer mortality to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Further covariate adjustments, stratification analyses, and a variety of sensitivity analyses were conducted to test the reliability and robustness of the results.ResultsThe all‐cause mortality in CVD patients with moderate/severe periodontitis was significantly higher than in those with no/mild periodontitis (HR: 1.25; 95% CI: 1.02–1.52; P = 0.03). The all‐cause mortality in participants with severe clinical attachment loss was significantly higher (HR: 1.07; 95% CI: 1.01–1.14; P = 0.01). However, no discrepancy in CVD or cancer mortality was observed between CVD patients with different periodontal status.ConclusionsOur findings from a longitudinal study with a large sample indicated significant but slightly higher all‐cause mortality in CVD patients with moderate/severe periodontitis than in those with no/mild periodontitis.

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Section: Discussionmentioning

confidence: 97%

Association between periodontitis and mortality of patients with cardiovascular diseases: A cohort study based on NHANES

Chen

Song

et al. 2023

Journal of Periodontology

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“…This is why active periodontal therapy is recommended in HP eradication treatments. [51,52] According to the results obtained in the current research, there are great deficiencies in the education of oral health within the Mexican population. The highest CPI value is significantly associated with age, place of residence, economic level, and educational level, which worsened as participants grew older, lived in rural environments, had low economic status, and in populations with lower educational level.…”

Section: Problems Of Healthmentioning

confidence: 88%

Periodontal health of a low socioeconomic level population in Yucatan (Mexico): A cross-sectional study

Morales-Ruiz,

Moreno-Barrera,

Ribas-Pérez

et al. 2023

Medicine

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With the objective of assessing the periodontal health status, treatment needs, and oral hygiene habits of the population of Mérida, in Mexico, a descriptive cross-sectional study was performed. Four hundred forty individuals individually completed a questionnaire on oral health, oral hygiene habits, and quality of life. Additionally, a complete clinical dental examination was performed for each. For the statistical analysis, continuous variables (means and standard deviation) and categorical variables (frequencies) were studied. The associations were made using the analysis of variance test for continuous variables and the Chi-square test for categorical variables. The critical value to identify statistically significant differences was P < .05. The main concern of the population was the possible untreated caries they thought they had, with 36.21% followed by pain with 14.62%. Possible periodontal issues were the main discomfort for only 9%. The percentage of the sample that required periodontal intervention by a specialist was 21.14%. Statistically significant differences were found between age, place of residence, socioeconomic level, and schooling. There are great deficiencies in oral health in the studied group, which is accompanied by a great need for periodontal treatment. Periodontal health is closely related to oral hygiene, so the related sociocultural level should also be taken into account for the study of oral health in the most vulnerable populations. It is crucial to establish strategies to promote oral health.

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“…Previous studies had found that inflammatory diseases increase the risk of death in people with diabetes (Brownrigg et al, 2012; Khouja et al, 2019). Periodontitis is reportedly strongly associated with systematic diseases and can cause systemic infection or systemic inflammation (Aberg & Helenius‐Hietala, 2016; Sung et al, 2022). Thus, periodontitis may influence the mortality of people with diabetes through systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and the risk of all‐cause and cause‐specific mortality among US adults with diabetes: A population‐based cohort study

Li,

Peng,

Shang

et al. 2023

J Clinic Periodontology

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AimTo evaluate the association between periodontitis, all‐cause and cause‐specific mortality, and its prognostic utility among adults with diabetes.Materials and MethodsPeriodontal health records were retrieved from the NHANES database for 4297 participants with diabetes aged >30 years at baseline during 1988–1994, 1999–2004 and 2009–2014. Multivariable Cox proportional hazards regression model was applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for moderate/severe periodontitis with all‐cause and cause‐specific mortality in participants with diabetes. Area under the curve (AUC) was used to assess predictive value.ResultsDuring a median follow‐up of 15.41 years, 1701 deaths occurred. After multivariate adjustments, moderate/severe periodontitis was significantly associated with increased risk of all‐cause (HR: 1.27; 95% CI: 1.07–1.50; p = .005) and cardiovascular disease (CVD)‐related (HR: 1.35, 95% CI: 1.03–1.76, p = .031) mortality in participants with diabetes. The absolute risk difference based on the cumulative incidence information was 0.022 (5‐year, 95% CI: 0.021–0.023) and 0.044 (10‐year, 95% CI: 0.041–0.048). Periodontitis improved the prediction of all‐cause (AUC: 0.652; 95% CI: 0.627–0.676) and CVD‐related (AUC: 0.649; 95% CI: 0.624–0.676) mortality over standard risk factors (all‐cause: AUC: 0.631; 95% CI: 0.606–0.656; CVD‐related: AUC: 0.629; 95% CI: 0.604–0.655).ConclusionsModerate/severe periodontitis is associated with an increased risk of all‐cause and CVD‐related mortality in adults with diabetes. Periodontitis might represent a marker for residual risk.

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Periodontitis, Helicobacter pylori infection, and gastrointestinal tract cancer mortality

Cited by 20 publications

References 60 publications

Association between periodontitis and mortality of patients with cardiovascular diseases: A cohort study based on NHANES

Association between periodontitis and mortality of patients with cardiovascular diseases: A cohort study based on NHANES

Periodontal health of a low socioeconomic level population in Yucatan (Mexico): A cross-sectional study

Periodontitis and the risk of all‐cause and cause‐specific mortality among US adults with diabetes: A population‐based cohort study

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