Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades

Li, Zheng; Ryu, Seung-Wook; Lee, Jungsul; Choi, Kyunghee; Kim, Sun Chang; Choi, Chulhee

doi:10.1016/j.bbrc.2016.01.148

Cited by 21 publications

(22 citation statements)

References 27 publications

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“…Coumaric and sinapic acids are both hydroxycinnamic acids, and coumaric acid was identified in all three ethyl acetate extracts of F. berteroana, C. inophyllum and B. pilosa ( Table 1 ), further pointing towards a potential Wnt/β-catenin target stimulation of hair growth of our extracts and fractions. Several other natural compounds have shown hair growth activity such as a tannin, corilagin [ 48 , 61 ], chalcones with 3-deoxysappanchalcone [ 67 ], terpenes, such as costunolide [ 68 ], or ginsenoside Rb1 [ 69 , 70 ]. A derivative of benzodiazepine named tianeptine was also found to have an effect on hair growth [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Hughes

Greff

et al. 2020

Molecules

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Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth.

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Section: Discussionmentioning

confidence: 99%

Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Hughes

Greff

et al. 2020

Molecules

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“…Matsuda H. et al, (2003) reported the promotion of HG by ginseng radix on cultured mouse vibrissal HF [59]. Korean red ginseng (KRG), in combination with topical MXD, is more effective than MXD for the promotion of HG in human clinical studies [60]. Ginsenoside is able to increase the hair shaft length and hair existent time, which is similar to the action of MXD in in vivo experimental models (topical treatment in nude mice), moreover, it stimulates hair shaft elongation in ex vivo cultures of vibrissa HF and suppresses TGF-β-induced phosphorylation of ERK in HeLa cells [61].…”

Section: Panax Ginseng Ca Meymentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…Likewise, topical administration of ginsenoside Re on to the back skin of nude mice for up to 45 days significantly increased hair-shaft length and hair existent time, and stimulated hair-shaft elongation in the ex vivo cultures of hair follicles isolated from C57BL/6 mouse. The hair-growth-promoting effects of ginsenoside Re were associated with the downregulation of TGF-β-pathway-related genes, which are involved in the control of hair-growth phase-transition-related signaling pathways [ 30 ]. It has been reported that brain-derived neurotrophic factor (BDNF) enhances transition from the anagen to the catagen phase through the activation of TGF-β [ 31 ].…”

Section: Biochemical Basis Of Hair-growth Promotion By Ginsengmentioning

confidence: 99%

“…It has been reported that brain-derived neurotrophic factor (BDNF) enhances transition from the anagen to the catagen phase through the activation of TGF-β [ 31 ]. Protopanaxatriol-type gisenoside Re promotes hair growth through the inhibition of TGF-β signaling pathways [ 30 ]. TGF-β-induced hair loss is associated with the hyperactivation of the c-Jun-N-terminal kinase (JNK) pathway [ 32 ].…”

Section: Biochemical Basis Of Hair-growth Promotion By Ginsengmentioning

confidence: 99%

Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

Choi

2018

IJMS

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The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one’s appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Through cyclical loss and new-hair growth, the number of hairs remains relatively constant. A variety of factors, such as hormones, nutritional status, and exposure to radiations, environmental toxicants, and medications, may affect hair growth. Androgens are the most important of these factors that cause androgenic alopecia. Other forms of hair loss include immunogenic hair loss, that is, alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are approved medications, and a few others (e.g., tofacitinib) are in progress, a wide variety of structurally diverse classes of phytochemicals, including those present in ginseng, have demonstrated hair growth-promoting effects in a large number of preclinical studies. The purpose of this review is to focus on the potential of ginseng and its metabolites on the prevention of hair loss and its underlying mechanisms.

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Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades

Cited by 21 publications

References 27 publications

Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

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