Arthroskopische Behandlung von Knorpelverletzungen am Sprunggelenk

Thomas, Michael; Jordan, Martin; Hamborg-Petersen, Ellen

doi:10.1007/s00113-015-0136-2

Cited by 11 publications

(2 citation statements)

References 32 publications

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“…www.advancedsciencenews.com www.biotechnology-journal.com the patient, thus, chondrocytes may have to be harvested from the uninjured ipsilateral knee and the problems of cultureexpanding the cells after harvest, namely cell senescence, [10] dedifferentiation, [11] and cost, preclude universal adoption across health organizations. [12] Due to the limitations associated with the use of chondrocytes, stem cells have emerged as a viable alternative for cartilage regenerative medicine strategies. The strategies involved in cartilage regeneration can be thought of as a triad.…”

Section: Richardmentioning

confidence: 99%

“…The technique has been shown to have favorable long‐term results when treating cartilage lesions in the ankle but a meta‐analysis in 2012 found insufficient evidence to support ACI over the simple and inexpensive technique of bone marrow stimulation . Furthermore, the two‐step procedure of ACI doubles the surgical risk to the patient, thus, chondrocytes may have to be harvested from the uninjured ipsilateral knee and the problems of culture‐expanding the cells after harvest, namely cell senescence, dedifferentiation, and cost, preclude universal adoption across health organizations . Due to the limitations associated with the use of chondrocytes, stem cells have emerged as a viable alternative for cartilage regenerative medicine strategies.…”

Section: Introductionmentioning

confidence: 99%

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Mesenchymal Stem Cells: Potential Role in the Treatment of Osteochondral Lesions of the Ankle

Tribe

McEwan

Taylor

et al. 2017

Biotechnology Journal

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Given articular cartilage has a limited repair potential, untreated osteochondral lesions of the ankle can lead to debilitating symptoms and joint deterioration necessitating joint replacement. While a wide range of reparative and restorative surgical techniques have been developed to treat osteochondral lesions of the ankle, there is no consensus in the literature regarding which is the ideal treatment. Tissue engineering strategies, encompassing stem cells, somatic cells, biomaterials, and stimulatory signals (biological and mechanical), have a potentially valuable role in the treatment of osteochondral lesions. Mesenchymal stem cells (MSCs) are an attractive resource for regenerative medicine approaches, given their ability to self‐renew and differentiate into multiple stromal cell types, including chondrocytes. Although MSCs have demonstrated significant promise in in vitro and in vivo preclinical studies, their success in treating osteochondral lesions of the ankle is inconsistent, necessitating further clinical trials to validate their application. This review highlights the role of MSCs in cartilage regeneration and how the application of biomaterials and stimulatory signals can enhance chondrogenesis. The current treatments for osteochondral lesions of the ankle using regenerative medicine strategies are reviewed to provide a clinical context. The challenges for cartilage regeneration, along with potential solutions and safety concerns are also discussed.

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Section: Richardmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cells: Potential Role in the Treatment of Osteochondral Lesions of the Ankle

Tribe

McEwan

Taylor

et al. 2017

Biotechnology Journal

View full text Add to dashboard Cite

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Arthroskopie und Knorpelrekonstruktion des oberen Sprunggelenkes

Streich

2018

Rückfußchirurgie

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Knorpelreparative Eingriffe am oberen Sprunggelenk

et al. 2017

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The success of each repair technique is dependent on the proper indication, addressing of co-morbidities like axis deviation or ligament instabilities, the experience of the surgeon and the appropriate rehabilitation. Mid- and long-term results are often good or excellent. Best results are seen in isolated cartilage defects without co-morbidities in patients younger than 40 years of age and non-smokers with normal BMI and early intervention. New cell-based therapies utilize scaffolds and biologic agents. They offer promising perspectives, although current data is inconsistent.

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Arthroskopische Behandlung von Knorpelverletzungen am Sprunggelenk

Cited by 11 publications

References 32 publications

Mesenchymal Stem Cells: Potential Role in the Treatment of Osteochondral Lesions of the Ankle

Mesenchymal Stem Cells: Potential Role in the Treatment of Osteochondral Lesions of the Ankle

Arthroskopie und Knorpelrekonstruktion des oberen Sprunggelenkes

Knorpelreparative Eingriffe am oberen Sprunggelenk

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