2017
DOI: 10.1002/biot.201700070
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Given articular cartilage has a limited repair potential, untreated osteochondral lesions of the ankle can lead to debilitating symptoms and joint deterioration necessitating joint replacement. While a wide range of reparative and restorative surgical techniques have been developed to treat osteochondral lesions of the ankle, there is no consensus in the literature regarding which is the ideal treatment. Tissue engineering strategies, encompassing stem cells, somatic cells, biomaterials, and stimulatory signal… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
4
0

Year Published

2017
2017
2019
2019

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

citations
Cited by 7 publications
(4 citation statements)
references
References 119 publications
(168 reference statements)
0
4
0
Order By: Relevance
“…However, this method is usually employed to repair the small area cartilage defect model, yet it does not address the large area of cartilage defects related to OA. At present, several scaffolds [polylactic-co-glycolic acid, polyethylene glycol, polylactic acid, polyglycolic acid, collagen, gelatin, hyaluronic acid (HA), and fibrin] are applied for the implantation of articular cartilage defects in experimental animal models[22]. They are still not used as routine treatments in clinical practice, although several studies have shown the safety and efficacy of MSC-based tissue engineering methods.…”
Section: How Mscs Can Treat Oa Disease In Preclinical Trials?mentioning
confidence: 99%
“…Osteochondral defects are usually encountered in young patients who actively take part in sports and entail severe pain, swelling and joint instability . In the study of Iqbal et al., IL 1‐hexyl‐3‐methylimidazolium acetate ([HMIM][Ac]) was used as a solvent to dissolve blends of collagen with polyvinyl alcohol to prepare hydrogels with good mechanical strength, outstanding fluid uptake ability and excellent biocompatibility.…”
Section: Ils‐assisted Processing Of Biopolymers For Biomedical Applicmentioning
confidence: 99%
“…Compared with allogeneic cells, generally, autogenous cartilage progenitor cells are more effective in the treatment of articular cartilage defect [29]. The emerging typical paradigm to apply MSCs in this disorder is [30]: (1) during the first operation, a cartilage biopsy is taken from areas of damaged cartilage within the ankle or knee; (2) chondrocytes are isolated from the biopsy via enzymatic digestion and cultured in 2D monolayer cultures; (3) monolayer culture-expanded chondrocytes are seeded on a collagen type I-III membrane; and (4) in the second operation, the cartilage lesion is prepared and the collagen membrane is cut to size, placed in the lesion and secured with fibrin glue.…”
Section: Mscs In Articular Cartilage Injurymentioning
confidence: 99%
“…Tseng et al summarize the technologies for obtaining multicellular spheroids using biomaterial substrates and their corresponding applications . Tribe et al summarize the potential role of mesenchymal stem cells in the treatment of osteochondral lesions of the ankle . In nine research articles, four papers focus on bone tissue engineering by combining stem cells with electrospun fibers, 3D ceramic scaffolds, and substrates immobilizing cytokines .…”
mentioning
confidence: 99%