Association of physical fitness and fatness with cognitive function in women with fibromyalgia

Soriano‐Maldonado, Alberto; Artero, Enrique G.; Segura‐Jiménez, Víctor; Aparicio, Virginia A.; Estévez‐López, Fernando; Álvarez‐Gallardo, Inmaculada C.; Munguía‐Izquierdo, Diego; Casimiro-Andújar, Antonio J.; Fernández, Manuel Delgado; Ortega, Francisco B.

doi:10.1080/02640414.2015.1136069

Cited by 14 publications

(10 citation statements)

References 41 publications

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“…Soriano-Maldonado et al . also suggested that there is no association between central adiposity and cognitive dysfunction in patients with fibromyalgia 40 . Of the two body composition parameters addressed in this study, there is a consistent association between skeletal muscle and the risk of AD, whereas conflicting results have been observed in studies on the association between obesity and the risk of AD in elderly subjects 41,42 .…”

Section: Discussionmentioning

confidence: 99%

Association of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects

Kim

Choi

Cho

et al. 2019

Sci Rep

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Increasing evidence indicates that sarcopenia and obesity can be risk factors for incident dementia. We investigated the association of body composition including muscle and visceral adipose tissue (VAT) with the probability of Alzheimer’s disease (AD) in healthy middle-aged and elderly subjects using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). This study included 110 healthy subjects with available whole-body FDG PET/CT scans and medical records. Muscle and VAT tissues were measured on the abdominal CT slice, and the PMOD Alzheimer’s discrimination FDG PET analysis tool (PALZ) score was evaluated on the brain PET of the same subject using software PALZ. Skeletal muscle index (r: −0.306; P = 0.031) was significantly negatively associated with the PALZ score in the elderly patients. Muscle area (β: −0.640; P = 0.043) and skeletal muscle index (β: −0.557; P = 0.043) were independently associated with the PALZ score in elderly subjects after adjustments for sex, duration of education, hypertension, diabetes mellitus, and smoking and drinking status. Increased muscle tissue was associated with a lower probability of AD in elderly subjects, but VAT was not associated with a lower probability of AD in middle-or older-aged adults.

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Section: Discussionmentioning

confidence: 99%

Association of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects

Kim

Choi

Cho

et al. 2019

Sci Rep

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“…Regarding the possible mediation of executive dysfunction by overweight, assessment of additional physical and behavioral variables may be informative in future studies. For example, assessments of physical activity, aerobic fitness, waste circumference or body fat may be help to uncover the underlying mechanisms [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, studies conducted in overweight and obese individuals drawn from the general population showed inverse associations between body mass index (BMI) and cognitive performance [ 40 – 43 ]. To our knowledge, only a single study has addressed this issue in FMS [ 44 ]. While aerobic fitness correlated positively with memory performance, BMI, percent body fat, fat-mass index and waist circumference showed no effect.…”

Section: Introductionmentioning

confidence: 99%

Executive function impairments in fibromyalgia syndrome: Relevance of clinical variables and body mass index

et al. 2018

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BackgroundSeveral investigations suggest the presence of deterioration of executive function in fibromyalgia syndrome (FMS). The study quantified executive functions in patients with FMS. A wide array of functions was assessed, including updating, shifting and inhibition, as well as decision making and mental planning. Moreover, clinical variables were investigated as possible mediators of executive dysfunction, including pain severity, psychiatric comorbidity, medication and body mass index (BMI).MethodsFifty-two FMS patients and 32 healthy controls completed a battery of 14 neuropsychological tests. Clinical interviews were conducted and the McGill Pain Questionnaire, Beck Depression Inventory, State-Trait Anxiety Inventory, Fatigue Severity Scale and Oviedo Quality of Sleep Questionnaire were presented.ResultsPatients performed poorer than controls on the Letter Number Sequencing, Arithmetic and Similarities subtests of the Wechsler Adult Intelligence Scale, the Spatial Span subtest of the Wechsler Memory Scale, an N-back task, a verbal fluency task, the Ruff Figural Fluency Test, the Inhibition score of the Stroop Test, the Inhibition and Shifting scores of the Five Digits Test, the Key Search Test and the Zoo Map Task. Moreover, patients exhibited less steep learning curves on the Iowa Gambling Task. Among clinical variables, BMI and pain severity explained the largest proportion of performance variance.ConclusionsThis study demonstrated impairments in executive functions of updating, shifting inhibition, decision making and planning in FMS. While the mediating role of pain in cognitive impairments in FMS had been previously established, the influence of BMI is a novel finding. Overweight and obesity should be considered by FMS researchers, and in the treatment of the condition.

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“…70 Self-reported questionnaires are useful to screen for dyscognition in patients with FM, but full neuropsychological testing may be required to delineate the extent of cognitive dysfunction. 163 In brain functional magnetic resonance imaging (fMRI) studies, 71,170 FM patients showed lower activation in the inhibition and attention networks and increased activation in other areas. Because inhibition and pain perception may use overlapping networks, resources taken up by pain processing may be unavailable for other processes.…”

Section: Common Featuresmentioning

confidence: 99%

AAPT Diagnostic Criteria for Fibromyalgia

Arnold

Bennett

Crofford

et al. 2019

The Journal of Pain

263

215

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Fibromyalgia (FM) is a common chronic pain disorder that presents diagnostic challenges for clinicians. Several classification, diagnostic and screening criteria have been developed over the years, but there continues to be a need to develop criteria that reflect the current understanding of FM and are practical for use by clinicians and researchers. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) public-private partnership with the U.S. Food and Drug Administration (FDA) and the American Pain Society (APS) initiated the ACTTION-APS Pain Taxonomy (AAPT) to develop a diagnostic system that would be clinically useful and consistent across chronic pain disorders. The AAPT established an international FM working group consisting of clinicians and researchers with expertise in FM to generate core diagnostic criteria for FM and apply the multidimensional diagnostic framework adopted by AAPT to FM. The process for developing the AAPT criteria and dimensions included literature reviews and synthesis, consensus discussions, and analyses of data from large population-based studies conducted in the United Kingdom. The FM working group established a revised diagnosis of FM and identified risk factors, course, prognosis, and pathophysiology of FM. Future studies will assess the criteria for feasibility, reliability, and validity. Revisions of the dimensions will also be required as research advances our understanding of FM.

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Association of physical fitness and fatness with cognitive function in women with fibromyalgia

Cited by 14 publications

References 41 publications

Association of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects

Association of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects

Executive function impairments in fibromyalgia syndrome: Relevance of clinical variables and body mass index

AAPT Diagnostic Criteria for Fibromyalgia

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