Executive function impairments in fibromyalgia syndrome: Relevance of clinical variables and body mass index

Guevara, Cristina Muñoz Ladrón de; Fernández-Serrano, María José; Paso, Gustavo A. Reyes del; Duschek, Stefan

doi:10.1371/journal.pone.0196329

Cited by 33 publications

(54 citation statements)

References 98 publications

(157 reference statements)

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“…Executive function is a new and exciting concept that has been recently investigated outside neuropsychology. Impaired executive function has been discovered in brain tumor, stroke in frontal lobes, Parkinson’s disease, fibromyalgia syndrome, and type 1 diabetes mellitus 25,26…”

Section: Discussionmentioning

confidence: 99%

Executive functioning and quality of life in acromegaly

Solomon¹,

Brănișteanu²,

Dumbravă³

et al. 2019

PRBM

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IntroductionActive acromegaly is a rare chronic endocrine disorder caused by excessive growth hormone (GH). Clinical studies suggest that cognitive performance is impaired in acromegaly – particularly executive function as well as short- and long-term memory. This study compared the quality of life (QoL) and executive functioning in acromegaly patients vs healthy controls.Materials and methodsThis was an observational case–control study on 38 subjects divided into 19 acromegaly patients and 19 matched controls. The groups were evaluated for QoL, attention, and executive function. All subjects completed Acromegaly Quality of Life Questionnaire (AcroQoL), Trail Making Test (parts A and B), Stroop, and phonemic fluency tests.ResultsAcromegaly patients had an AcroQoL global score that was significantly lower than controls. There were significant differences between the acromegaly group and the control group in terms of the physical effects (P=0.001) and appearance (P<0.001) but not for personal relationships (P=0.421). Acromegaly patients performed worse in the trail making test part B. They provided significantly fewer words than healthy subjects in phonemic fluency testing. Although patients performed generally worse than controls, no significant differences were noted in the trail making test part A, Stroop test, and the constrained phonemic fluency.ConclusionAcromegaly patients display worse executive functioning than healthy controls and have a decreased QoL.

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Section: Discussionmentioning

confidence: 99%

Executive functioning and quality of life in acromegaly

Solomon¹,

Brănișteanu²,

Dumbravă³

et al. 2019

PRBM

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“…All participants were right-handed. The study is part of a larger project on cognition in FMS [ 2 , 6 ].…”

Section: Methodsmentioning

confidence: 99%

Cognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulation

et al. 2018

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BackgroundFibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain and diffuse tenderness, accompanied by complaints including morning stiffness, fatigue, insomnia and affective symptoms. In addition, affected patients frequently experience cognitive impairments such as concentration difficulties, forgetfulness or problems in planning and decision-making. These deficits are commonly ascribed to interference between nociceptive and cognitive processing.MethodThe present study investigated the association of cognitive performance with (a) pain responses to low intensity pressure stimulation (0.45–2.25 kg/cm2), (b) responses to stronger (above-threshold) stimulation (2.70 kg/cm2), and (c) pain threshold and tolerance in 42 women with FMS. Tests of attention, memory, processing speed, and executive functions were applied.ResultsWhile no significant correlations were seen for pain threshold and pain tolerance, inverse associations arose between pain intensity ratings during pressure stimulation and performance in all evaluated cognitive domains. The magnitude of the correlations increased with decreasing stimulus intensity.ConclusionsIt may be concluded that pain experience during somatosensory stimulation of low intensity is more closely related to attention, memory and executive functions in FMS than the traditional measures of pain threshold and pain tolerance. Considering that pain responses to low intensity stimulation reflect the hyperalgesia and allodynia phenomena characterizing FMS, it may be hypothesized that central nervous pain sensitization is involved in cognitive impairments in the disorder.

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“…Physical inactivity and sedentary lifestyles, and the associated increase in body mass index (BMI), have been suggested as factors associated with FMS 33,34. Activity avoidance is associated with poorer function in individuals with chronic pain, and predicted poorer physical and psychological functioning and higher pain-related interference with daily life 35.…”

Section: Vulnerability Factors In Fibromyalgiamentioning

confidence: 99%

<p>Psychological impact of fibromyalgia: current perspectives</p>

Galvez-Sánchez¹,

Duschek²,

Paso³

2019

PRBM

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Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread and persistent musculoskeletal pain and other frequent symptoms such as fatigue, insomnia, morning stiffness, cognitive impairment, depression, and anxiety. FMS is also accompanied by different comorbidities like irritable bowel syndrome and chronic fatigue syndrome. Although some factors like negative events, stressful environments, or physical/emotional traumas may act as predisposing conditions, the etiology of FMS remains unknown. There is evidence of a high prevalence of psychiatric comorbidities in FMS (especially depression, anxiety, borderline personality, obsessive-compulsive personality, and post-traumatic stress disorder), which are associated with a worse clinical profile. There is also evidence of high levels of negative affect, neuroticism, perfectionism, stress, anger, and alexithymia in FMS patients. High harm avoidance together with high self-transcendence, low cooperativeness, and low self-directedness have been reported as temperament and character features in FMS patients, respectively. Additionally, FMS patients tend to have a negative self-image and body image perception, as well as low self-esteem and perceived self-efficacy. FMS reduces functioning in physical, psychological, and social spheres, and also has a negative impact on cognitive performance, personal relationships (including sexuality and parenting), work, and activities of daily life. In some cases, FMS patients show suicidal ideation, suicide attempts, and consummated suicide. FMS patients perceive the illness as a stigmatized and invisible disorder, and this negative perception hinders their ability to adapt to the disease. Psychological interventions may constitute a beneficial complement to pharmacological treatments in order to improve clinical symptoms and reduce the impact of FMS on health-related quality of life.

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Executive function impairments in fibromyalgia syndrome: Relevance of clinical variables and body mass index

Cited by 33 publications

References 98 publications

Executive functioning and quality of life in acromegaly

Executive functioning and quality of life in acromegaly

Cognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulation

<p>Psychological impact of fibromyalgia: current perspectives</p>

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