False-negative type-specific glycoprotein G antibody responses in STI clinic patients with recurrent HSV-1 or HSV-2 DNA positive genital herpes, The Netherlands

Rooijen, Martijn S. van; Roest, Wim; Hansen, Gino; Kwa, David; Vries, Henry J. C. de

doi:10.1136/sextrans-2015-052213

Cited by 9 publications

(6 citation statements)

References 16 publications

(16 reference statements)

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“…A further important misclassification bias is related to the inaccuracies of the STI testing algorithms used. In particular, HSV-2 serological testing including the testing algorithm used in the UHSBS is characterized by relatively poor sensitivity and specificity [ 34 , 35 ]. A metanalysis of the performance of HSV-2 serological testing in sub Saharan Africa found that the Kalon HSV-2 EIA used in the UHSBS had a sensitivity of 95% (95% CI: 93%–97%) and a specificity of 91% (95% CI: 86%–95%) [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

HIV prevalence by ethnic group covaries with prevalence of herpes simplex virus-2 and high-risk sex in Uganda: An ecological study

Kenyon

2018

PLoS ONE

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BackgroundHIV prevalence varies from 1.7% to 14.8% between ethnic groups in Uganda. Understanding the factors responsible for this heterogeneity in HIV spread may guide prevention efforts.MethodsWe evaluated the relationship between HIV prevalence by ethnic group and a range of risk factors as well as the prevalence of herpes simplex virus-2 (HSV-2), syphilis and symptomatic STIs in the 2004/2005 Uganda HIV/AIDS Sero-Behavioural Survey—a two stage, nationally representative, population based survey of 15–59-year-olds. Spearman’s correlation was used to assess the relationship between HIV prevalence and each variable.ResultsThere was a positive association between HIV prevalence and HSV-2, symptomatic STIs and high-risk sex (sex with a non-cohabiting, non-marital partner) for women. Non-significant positive associations were present between HIV and high-risk sex for men and lifetime number of partners for men and women.ConclusionVariation in sexual behavior may contribute to the variations in HIV, HSV-2 and other STI prevalence by ethnic group in Uganda. Further work is necessary to delineate which combinations of risk factors determine differential STI spread in Uganda.

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Section: Discussionmentioning

confidence: 99%

HIV prevalence by ethnic group covaries with prevalence of herpes simplex virus-2 and high-risk sex in Uganda: An ecological study

Kenyon

2018

PLoS ONE

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“…According to Bradley et al, in 2005–2010, the seroprevalence of HSV‐1 was 53.9%, and the seroprevalence of HSV‐2 was 15.7% . These numbers might be even higher because the epidemiological use of type‐specific HSV serology can be hampered by false‐negative results, especially if based on a single test, and the antibodies formed against either virus are highly cross‐reactive .…”

Section: Discussionmentioning

confidence: 99%

“…It is not uncommon to have a false‐negative result because low‐level HSV antibodies can be below the level of detection of the HSV serologic assays; therefore, the recipient's pretransplant serology could have been a false‐negative result. False‐negative test results can be as high as 30%, depending on the assay in use .…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction

Hemmersbach‐Miller

Duronville

Sethi

et al. 2017

American Journal of Transplantation

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Interstitial nephritis due to viruses is well‐described after solid organ transplantation. Viruses implicated include cytomegalovirus; BK polyomavirus; Epstein–Barr virus; and, less commonly, adenovirus. We describe a rare case of hemorrhagic allograft nephritis due to herpes simplex virus type 1 at 10 days after living donor kidney transplantation. The patient had a favorable outcome with intravenous acyclovir and reduction of immunosuppression.

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“…Studies suggest that 12–30% of patients lose their HSV type-specific IgG antibodies depending on their HSV types and the test used. 37…”

Section: Diagnosismentioning

confidence: 99%

2017 European guidelines for the management of genital herpes

Patel¹,

Kennedy²,

Clarke³

et al. 2017

Int J STD AIDS

102

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Genital herpes is one of the commonest sexually transmitted infections worldwide. Using the best available evidence, this guideline recommends strategies for diagnosis, management, and follow-up of the condition as well as for minimising transmission. Early recognition and initiation of therapy is key and may reduce the duration of illness or avoid hospitalisation with complications, including urinary retention, meningism, or severe systemic illness. The guideline covers a range of common clinical scenarios, such as recurrent genital herpes, infection during pregnancy, and co-infection with human immunodeficiency virus.

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False-negative type-specific glycoprotein G antibody responses in STI clinic patients with recurrent HSV-1 or HSV-2 DNA positive genital herpes, The Netherlands

Cited by 9 publications

References 16 publications

HIV prevalence by ethnic group covaries with prevalence of herpes simplex virus-2 and high-risk sex in Uganda: An ecological study

HIV prevalence by ethnic group covaries with prevalence of herpes simplex virus-2 and high-risk sex in Uganda: An ecological study

Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction

2017 European guidelines for the management of genital herpes

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