Commercial type-specific gG HSV-1 or HSV-2 antibody assays were false negative in 12-30% of patients with recurrent HSV-1 or HSV-2 DNA positive genital lesions. The clinical and epidemiological use of type-specific HSV serology can be hampered by false-negative results, especially if based on a single test.
notified for STI, concurrent urogenital Ct and > 10 partners, but not with pharyngeal symptoms. Women reporting sex work had a lower risk, while women with pharyngeal gonorrhoea and MSM with anorectal Ct had a higher risk for PCt. 53% of MSM and 32% of women with PCt had no concurrent anogenitial Ct.Of 43 (29%) MSM and 55 (34%) women, follow-up swabs and questionnaire data were available. The median time between both visits was 10 days. PCt persisted in 27 (63%) MSM and in 35 (64%) women. In both groups 50% had unprotected active oral sex between first and second visit, but this did not affect persistence.Among MSM no determinants for persistence were detected; among women being notified for STI, younger age and urogenital Ct were significantly associated with persistence in univariate analysis.Among clients (n = 16) whose second visit was more than 3 weeks after the first visit, 11 (69%) had PCt at second visit. Discussion The prevalence of PCt is low among STI clinic clients, but persistence is common. Therefore, the pharynx is a potential reservoir for ongoing Ct transmission.
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