2017
DOI: 10.1111/ajt.14022
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Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction

Abstract: Interstitial nephritis due to viruses is well‐described after solid organ transplantation. Viruses implicated include cytomegalovirus; BK polyomavirus; Epstein–Barr virus; and, less commonly, adenovirus. We describe a rare case of hemorrhagic allograft nephritis due to herpes simplex virus type 1 at 10 days after living donor kidney transplantation. The patient had a favorable outcome with intravenous acyclovir and reduction of immunosuppression.

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Cited by 7 publications
(3 citation statements)
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References 13 publications
(18 reference statements)
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“…Notably, HTR and LuTR have the highest risk of developing pneumonitis compared with other SOTRs [ 115 ]. Recently, a rare case of hemorrhagic allograft nephritis due to HSV-1 was described in a KTR who did not receive HCMV prophylaxis at day 10 after transplantation [ 116 ].…”
Section: Herpes Simplex Virusmentioning
confidence: 99%
“…Notably, HTR and LuTR have the highest risk of developing pneumonitis compared with other SOTRs [ 115 ]. Recently, a rare case of hemorrhagic allograft nephritis due to HSV-1 was described in a KTR who did not receive HCMV prophylaxis at day 10 after transplantation [ 116 ].…”
Section: Herpes Simplex Virusmentioning
confidence: 99%
“…Treatment with acyclovir is often required in these patients, which can lead to nephrotoxicity, by far the most common cause of AKI in HSV infections. Of note, HSV-related nephropathy by direct or indirect mechanisms appears to be very rare, and only a few case reports of HSV nephritis [ 147 , 148 , 149 , 150 ] and glomerulonephritis [ 151 , 152 ] have been reported so far.…”
Section: The Herpesviridae Familymentioning
confidence: 99%
“…описали гострий геморрагічний інтерстиційний нефрит, зумовлений вірусом простого герпесу 1 типу, що розвинувся невдовзі після пересадки алогенної нирки у зв'язку із застосуванням імуносупресивного лікування для попередження імунної реакції відторгнення трансплантату. Вдалося добитися сприятливого результату після курсу в/в ацикловіру та зменшення доз застосовуваних цитостатичних хіміопрепаратів [13] Maiese A. зі спів. опублікували дані про фатальну реактивовану EBV-інфекцію з розвитком менінгоенцефаліту, фокального міокардиту та інтерстиційного нефриту у 74-річного пацієнта без очевидних ознак імуносупресії [19].…”
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