“…The lower observed sensitivity for CoV HKU-1 and CoV OC43 may be due to the low positive sample number for this target and the fact that NxTAG-RPP detected two of the three positives. This performance represented a significant improvement from the previous Luminex xTAG RVPv2 assay (15,16,22). However, the assay was found to be oversensitive, with false-positive results noted in 12 of 20 targets (60.0%) (adenovirus, HCoV-229E, HCoV-OC43, HCoV-NL63, enterovirus/rhinovirus, influenza A/H3, hMPV, PIV2, PIV3, PIV4, RSV, and HBoV).…”