Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues

Rotimi, Solomon O.; Ojo, D. A.; Talabi, O. A.; Ugbaja, Regina Ngozi; Balogun, Elizabeth Abidemi; Ademuyiwa, Oladipo

doi:10.1186/s12944-015-0011-8

Cited by 16 publications

(22 citation statements)

References 41 publications

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“…Accumulation of triglycerides is one of the leading risk factors in coronary heart disease (CHD). Lipid and lipoprotein abnormalities have been shown to play a major role in the pathogenesis and progression of several disease conditions [28]. Fasting Blood Sugar (mg/dL)…”

Section: Resultsmentioning

confidence: 99%

Effect of Oral Intake of African Locust Bean on Fasting Blood Sugar and Lipid Profile of Albino Rats

Airaodion

Ogbuagu

et al. 2019

AJRB

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Background: African locust bean is a condiment believed to be for the people of low class. Its health importance has not been fully known especially to the so-called high class. Aim: This study is aimed at investigating the effect of African locust bean on fasting blood sugar and lipid profile of albino rats. Methods: African locust bean (ALB) was purchased from a local market at Orita-Challenge area of Ibadan, Nigeria. They were sun dried and milled into powder using an electronic blender. The powder was extracted with n-hexane (40–60°C) in a soxlet extractor for 18 hours. The defatted, dried marc was repacked and then extracted with methanol. The dried marc was extracted with methanol in the soxlet apparatus for 10 hours. The methanol solution was subsequently concentrated in a rotatory evaporator at 40°C. Ten adult male albino rats with body weight between 100 and 120 g were purchased from the Animal Holding Unit of the Department of Physiology, University of Ibadan, Nigeria. They were allowed 7 days acclimatization period and were divided randomly into 2 groups of five rats each. Animals in group 1 were administered normal saline solution while those in group 2 were administered extract of African locust bean. The animals were exposed to the African Locust Bean and saline solution at a dose of 3 ml per 100 g body weight 12 hourly via oral route of administration. After fourteen days of administration, the animals were fasted overnight and anaesthetized using diethyl ether. Blood samples were collected by cardiac puncture. Results: ALB was observed to significantly lower fasting blood sugar, total cholesterol and triglyceride but increased HDL-cholesterol significantly when compared to those of the control group at p<0.05. LDL-cholesterol was not significantly different when animals treated with ALB were compared with those of the control group. Conclusion: Increased blood sugar and hyperlipidemia has been implicated in diabetes. Cholesterolgenesis is a major onset of atherosclerosis and subsequent cardiovascular diseases. Therefore, ALB can serve as prophylaxis and remedies for several diseases caused by hyperglycemia and hyperlipidemia such as diabetes and coronary heart disease.

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Section: Resultsmentioning

confidence: 99%

Effect of Oral Intake of African Locust Bean on Fasting Blood Sugar and Lipid Profile of Albino Rats

Airaodion

Ogbuagu

et al. 2019

AJRB

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Section: Discussionmentioning

confidence: 99%

Effect of Methanolic Extract of Corchorus olitorius Leaves on Hypoglycemic and Hypolipidaemic Activities in Albino Rats

Airaodion

Akinmolayan²,

Ogbuagu

et al. 2019

APRJ

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Aim: This study sought to investigate the hypoglycemic and hypolipidaemic effect of methanolic extract of Corchorus olitorius leaves in Albino rats. Methods: Fresh plants of C. olitorius were harvested from the Institute of Agricultural Research and Training, Ibadan. The leaves were dried and extracted using soxhlet apparatus and methanol as the solvent. The methanol was evaporated in a rotary evaporator at 35°C with a yield of 2.17 g which represents a percentage yield of 8.68%. Ten adult male albino rats with body weight between 100 and 120 g were used for this study. They were randomly divided into two groups of five rats each. Animals in group 1 were administered saline solution while those in group 2 were administered C. olitorius extract. The animals were exposed to the extract and saline solution at a dose of 3 mL per 100 g body weight 12 hourly via oral route of administration. After fourteen days of administration, the animals were fasted overnight and anaesthetized using diethyl ether. Blood samples were collected by cardiac puncture. Fasting blood sugar and lipid profile were determined using standard methods. Results: C. olitorius leaves was observed to significantly lower fasting blood sugar, total cholesterol, LDL-cholesterol and triglyceride but increased HDL-cholesterol and HDL/LDL-cholesterol ratio significantly when compared to those of the control group at p<0.05. Conclusion: The result of this study implies that C. olitorius leaves are of significant health importance as far as hyperglucosemia and hyperlipidaemia is concerned. It could also be exceedingly helpful in the control of obesity and hypertension. This pharmacological study is a useful tool for further drug development from the natural plant products.

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“…Accumulation of triglycerides is one of the leading risk factors in coronary heart disease (CHD). Lipid and lipoprotein abnormalities play an important role in the pathogenesis and progression of several disease conditions [42].…”

Section: Discussionmentioning

confidence: 99%

Hypolipidaemic and Antidiabetic Potency of Allium cepa (Onions) Bulb in Alloxan-Induced Diabetic Rats

Airaodion¹,

Akaninyene²,

Ngwogu³

et al. 2020

Act Scie Nutr

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Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues

Cited by 16 publications

References 41 publications

Effect of Oral Intake of African Locust Bean on Fasting Blood Sugar and Lipid Profile of Albino Rats

Effect of Oral Intake of African Locust Bean on Fasting Blood Sugar and Lipid Profile of Albino Rats

Effect of Methanolic Extract of Corchorus olitorius Leaves on Hypoglycemic and Hypolipidaemic Activities in Albino Rats

Hypolipidaemic and Antidiabetic Potency of Allium cepa (Onions) Bulb in Alloxan-Induced Diabetic Rats

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