Hypolipidaemic and Antidiabetic Potency of Allium cepa (Onions)  Bulb in Alloxan-Induced Diabetic Rats

Airaodion, Augustine I.; Akaninyene, Ime U; Ngwogu, Kenneth O.; Ekenjoku, John A.; Ngwogu, Ada C.

doi:10.31080/asnh.2020.04.0648

Cited by 10 publications

(10 citation statements)

References 29 publications

(44 reference statements)

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“…For this reason, scientists are looking at natural resources such as medicinal plants as alternative therapeutic agents against diabetes, as they are less harmful and have a lot of pharmacological value [ 98 , 99 ]. At present, many studies [ 97 , 98 , 100 ] are being performed on A. cepa to investigate its antidiabetic activities, and one of the experiments which was tested on diabetic rats showed that the aqueous extract of onions reduced blood glucose level in the same manner as that of glibenclamide, a conventional antidiabetic drug. The results also reported that the onion extracts contained kaempferol-3-O- β -D-6 ( P- coumaroyl) glucopyranoside which is responsible for the antidiabetic effect by promoting glucose uptake in rat soleus muscle [ 101 ].…”

Section: Therapeutic Potential Of Allium Cepamentioning

confidence: 99%

“…In addition, another experiment which was also conducted by Airaodion et al using the ethanol extract of onions found that the extract contained quercetin and rutin which stimulated glucose uptake in rat skeletal L6 myotubes by increasing GLUT-4 protein synthesis and its mobilization from the cytoplasm to the plasma membrane, as well as triggering the PI-3-K/Akt signaling pathway to regulate glucose transport [ 103 ]. Furthermore, in a study of six groups of alloxan-induced diabetic rats, three groups were treated with varying doses of A. cepa juice for 14 days, and the results found that the rats treated with onion juice had a markedly decreased blood glucose level than the rats who were not [ 100 ]. Jini and his group synthesized silver nanoparticles from A. cepa and an in vitro study was designed to evaluate those silver nanoparticles activity against diabetes.…”

Section: Therapeutic Potential Of Allium Cepamentioning

confidence: 99%

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Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Chakraborty

Uddin

Zidan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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As Allium cepa is one of the most important condiment plants grown and consumed all over the world, various therapeutic and pharmacological effects of A. cepa were reviewed. Onion (Allium cepa) is a high dietary fiber-rich perennial herb that is placed under the family Amaryllidaceae. It contains high concentration of folic acid, vitamin B6, magnesium, calcium, potassium, and phosphorus as well as vitamins and minerals. It is widely used as an antimicrobial agent, but it showed anticancer, antidiabetic, antioxidant, antiplatelet, antihypertensive, and antidepressant effects and neuroprotective, anti-inflammatory, and antiparasitic effects and so on. It is said to have beneficial effects on the digestive, circulatory, and respiratory systems, as well as on the immune system. This review article was devoted to discussing many health benefits and traditional uses of onions in pharmacological perspectives, as well as the safety/toxicological profile. If more detailed research on this perennial herb is conducted, it will open the door to an infinite number of possibilities.

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Section: Therapeutic Potential Of Allium Cepamentioning

confidence: 99%

Section: Therapeutic Potential Of Allium Cepamentioning

confidence: 99%

Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Chakraborty

Uddin

Zidan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Given that a high HDLcholesterol/LDL-cholesterol ratio has been demonstrated to be advantageous and to be a sign of a lower risk of cardiovascular diseases, this likely explains why P. biglobosa may reduce the chance of developing heart ailments [49]. Two of the four major subgroups of plasma lipoproteins, HDL and LDL, are involved in lipid metabolism and the transfer of triglycerides, cholesterol, and cholesterol esters between tissues [50,51]. According to numerous studies, there is a negative correlation between plasma HDL cholesterol levels and the risk of cardiovascular disease, suggesting that HDL cholesterol has some protective effects against atherosclerosis [19,44].…”

Section: Legend: Tc = Total Cholesterol Tg = Triglyceride Hdl-c = Hig...mentioning

confidence: 99%

“…The protein elements needed to activate lipoprotein lipase, which releases fatty acids that can be oxidized by the -oxidation pathway to produce energy, are also provided by HDLcholesterol [50,51]. Most notably, because of its antioxidant property, HDL cholesterol can lessen the oxidation of LDL cholesterol and the atherogenic consequences of oxidized LDL cholesterol [57].…”

Section: Legend: Tc = Total Cholesterol Tg = Triglyceride Hdl-c = Hig...mentioning

confidence: 99%

Chemotherapeutic Propensity of Africa Locust Bean (Parkia biglobosa) Seed on Lipid Profile against Potassium Bromate-induced Cardiotoxicity

Ugwu

Iwuoha

Chika-Igwenyi

et al. 2022

JALSI

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Background: Cardiovascular disease cases are on the increase despite many standard medical practices. Some disorders have been successfully treated by medicinal plants. Aim: The current study was designed to assess the chemotherapeutic propensity of Parkia biglobosa against potassium bromate-induced cardiotoxicity. Methodology: Using a soxhlet extractor with ethanol as the solvent, P. biglobosa was extracted. Twenty-four mature male Wistar rats were randomly divided into groups A, B, C, and D after being acclimated in the lab. Oral distilled water was administered to Group A. Although groups C and D likewise received 100 and 200 mg/kg body weight of P. biglobosa, respectively, the animals in groups B, C, and D received 100 mg/kg body weight of potassium bromate (KBrO3). Rats received daily doses of freshly prepared potassium bromate and P. biglobosa extract by oral gavage. After receiving the therapy for 28 days, the animals were slaughtered 24 hours after the last treatment ended while being lightly sedated with diethyl ether. Through a heart puncture, blood was taken. Additionally, the animals' hearts were removed and homogenized. Standard techniques were used to measure the lipid profile parameters. Results: When compared to the untreated group, the plasma levels of total cholesterol, triglycerides, LDL, VLDL, and the CHD risk ratio were significantly higher in the study's animals treated with KBrO3, while HDL and the HDL/LDL ratio were significantly lower. Compared to the control group, administration of KBrO3 significantly decreased cardiac levels of total cholesterol, HDL and HDL/LDL ratio, while increasing levels of triglycerides, LDL, and VLDL, as well as the coronary heart disease (CHD) risk ratio. P. biglobosa attenuated these perturbations in a dose-dependent manner. Conclusion: Potassium bromate caused increase in the levels of triglycerides, LDL, VLDL and a reduction in HDL and HDL/LDL ratio and this effect was found to be attenuated by intake of P. biglobosa. This effect will result in the reduction of CHD risk factors induced by potassium bromate.

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“…Coronary heart disease (CHD) or cardiovascular diseases are recognized to be one of the most important reasons of morbidity and mortality and imposes tremendously heavy socio-economic burden worldwide. There are varieties of risk factors in the literature which increases the incidence of CHD such as hyperlipidemia [9][10][11]. CHD occurs when cholesterol accumulates on the artery walls, creating plaques.…”

Section: Introductionmentioning

confidence: 99%

Effect of Parkia biglobosa seed on lipid profile of dexamethasone-treated pregnant rats

Oladele¹,

Oluokun²,

Adam³

2021

World J. Bio. Pharm. Health Sci.

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This study was aimed at evaluating the effect of Parkia biglobosa seed on dexamethasone-treated pregnant rats. Locust bean seeds were purchased from an open market in Ado Ekiti, Nigeria. It was processed and ground into powder which was subsequently used in formulating feed for experimental animals. Fifteen female pregnant rats were divided in three groups of five each. Animals in group A were exposed to standard animal feed only. This served as the control group. Those in group B were exposed to animal feed mixed with locust beans + 0.3 mg/kg body weight of dexamethasone, while those in group C were exposed to animal feed mixed with locust beans. At the end of eight days treatment, animals were sacrificed and blood sample was collected into EDTA bottles and centrifuged. Plasma was separated and used for the determination of glucose and lipid profile. Exposure of animals to dexamethasone was observed to significantly (p<0.05) increased the concentration of plasma glucose concentration when compared with the control as well as animals treated with P. biglobosa only. Animals treated with dexamethasone along with P. biglobosa were observed to have higher concentrations of triglyceride, total cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) when compared with those in animals in the control group as well as those treated with P. biglobosa only. Observations from this study revealed that dexamethasone adversely perturbed and unhinged plasma glucose and lipid profile in female pregnant rats while P. biglobosa-formulated diet was observed to be a potent hypoglycemic and hypolipidemic agent.

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Hypolipidaemic and Antidiabetic Potency of Allium cepa (Onions) Bulb in Alloxan-Induced Diabetic Rats

Abstract: 60. Airaodion AI., et al. "Pharmacotherapeutic effect of methanolic extract of Telfairia occidentalis leaves on glycemic and lipidemic indexes of alloxan-induced diabetic rats".

Cited by 10 publications

References 29 publications

Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Chemotherapeutic Propensity of Africa Locust Bean (Parkia biglobosa) Seed on Lipid Profile against Potassium Bromate-induced Cardiotoxicity

Effect of Parkia biglobosa seed on lipid profile of dexamethasone-treated pregnant rats

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