Chemotherapeutic Propensity of Africa Locust Bean (Parkia biglobosa) Seed on Lipid Profile against Potassium Bromate-induced Cardiotoxicity

Abstract

Background: Cardiovascular disease cases are on the increase despite many standard medical practices. Some disorders have been successfully treated by medicinal plants.
 Aim: The current study was designed to assess the chemotherapeutic propensity of Parkia biglobosa against potassium bromate-induced cardiotoxicity.
 Methodology: Using a soxhlet extractor with ethanol as the solvent, P. biglobosa was extracted. Twenty-four mature male Wistar rats were randomly divided into groups A, B, C, and D after being acclimated in the lab. Oral distilled water was administered to Group A. Although groups C and D likewise received 100 and 200 mg/kg body weight of P. biglobosa, respectively, the animals in groups B, C, and D received 100 mg/kg body weight of potassium bromate (KBrO3). Rats received daily doses of freshly prepared potassium bromate and P. biglobosa extract by oral gavage. After receiving the therapy for 28 days, the animals were slaughtered 24 hours after the last treatment ended while being lightly sedated with diethyl ether. Through a heart puncture, blood was taken. Additionally, the animals' hearts were removed and homogenized. Standard techniques were used to measure the lipid profile parameters.
 Results: When compared to the untreated group, the plasma levels of total cholesterol, triglycerides, LDL, VLDL, and the CHD risk ratio were significantly higher in the study's animals treated with KBrO3, while HDL and the HDL/LDL ratio were significantly lower. Compared to the control group, administration of KBrO3 significantly decreased cardiac levels of total cholesterol, HDL and HDL/LDL ratio, while increasing levels of triglycerides, LDL, and VLDL, as well as the coronary heart disease (CHD) risk ratio. P. biglobosa attenuated these perturbations in a dose-dependent manner.
 Conclusion: Potassium bromate caused increase in the levels of triglycerides, LDL, VLDL and a reduction in HDL and HDL/LDL ratio and this effect was found to be attenuated by intake of P. biglobosa. This effect will result in the reduction of CHD risk factors induced by potassium bromate.

Nephro-protective Efficacy of African Locust Bean Seed against Potassium Bromate-induced Renal Damage

“…Phytate, tannin, oxyalate, and hydrogen cyanide are a few antinutritional components found in seeds [2]. The extract of African locust bean (ALB) is antibacterial [4], antidiabetic [7], antifungal [8], anti-inflammatory [9], anti-diarrheal [10], antihypertensive [11], hypoglycemia [12], hypolipidemic [13], and hepatoprotective [14] in addition to having many beneficial effects. A recent study by Ezirim et al [15] shown that ALB seed can alleviate testicular toxicity caused by potassium bromate.…”

A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

“…The higher lipid peroxidation in the kidney after As treatment may be caused by the formation of superoxide anion radical according to the decreased SOD activity in the kidney as shown in Figure 3 (160,161). When molecular oxygen interacts with the dimethyl arsine metabolite of dimethyl As acid, free radicals are produced.…”

Protective and Curative Potential of Ethanol Leaf Extract of Corchorus olitorius against Potassium Bromate-Induced Renal Toxicity

“…Humans who are acutely intoxicated with KBrO 3 can develop renal failure, neuropathological abnormalities, and thrombocytopenia, while those who are chronically intoxicated have been shown to develop a number of renal and nonrenal malignancies [5]. According to experimental studies, KBrO 3 can cause oxidative stress [6], hepatotoxicity [7], nephrotoxicity [8], testicular toxicity [9], dyslipidemia [10], lower sperm quality [11], decreased male reproductive hormones [12], abnormalities in coagulation factors [13], and other negative effects.…”