Haff disease complicated by multiple organ failure after crayfish consumption: a case study

Feng, Gang; Luo, Qiancheng; Zhuang, Ping; Guo, Enwei; Yu, Yao

doi:10.5935/0103-507x.20140062

Cited by 26 publications

(41 citation statements)

References 7 publications

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“…Subsequent outbreaks mostly occurred in the Jiangsu Province [16,17,18,19,28], an eastern coastal province, and recurred in its capital, Nanjing [12,13,14,15,16,17,27,28]. Isolated cases and small outbreaks have occurred in other cities since 2010 [20,21,22,23,24,25,26]. There have so far been two outbreaks with a large number of subjects affected— the October 2009 outbreaks in Lianzhou and Liannan, Guangdong Province ( n = 54) [11], and July–September 2010 outbreaks in Nanjing, Jiangsu Province ( n = 42) [12,13,14,15].…”

Section: Discussionmentioning

confidence: 99%

“…Subsequent outbreaks mostly occurred in the Jiangsu Province—Nanjing in 2010 [12,13,14,15,27,28], 2012 [16], and 2014 [17], Yangzhou in 2012 [18], Huai’an in 2013 [17], and Yancheng in 2015 [19]. Isolated outbreaks occurred in other cities since 2010—Shijiazhuang, Hebei Province, in 2010 [20], Yueyang, Hunan Province, in 2010 [22], Shanghai in 2013 [23], Wuhu, Anhui Province, in 2014 [24], Shenzhen in 2016 [25], and Hong Kong (two imported cases from Shenzhen) in 2016 [26]. In Baoding, Hebei Province [21], the year of occurrence of the outbreaks was not stated in the report of 2014.…”

Section: Reports Of Haff Disease From Chinamentioning

confidence: 99%

“…As can be seen in Table 1, Haff disease outbreaks occurred predominately in the summer [9,12,13,14,15,16,17,18,22,23,24,25,26]. Two outbreaks had occurred in October [11] and May [19] when the mean daytime temperature in Lianzhou/Liannan and Yancheng was 27 °C and 30 °C, respectively.…”

Section: Reports Of Haff Disease From Chinamentioning

confidence: 99%

“…Crayfish accounted for almost all the outbreaks of Haff disease in China since 2000 [9,12,13,14,15,16,17,18,19,20,21,23,24,25,26]. Affected subjects generally had ingested 10 pieces or 400 g or more of crayfish.…”

Section: Reports Of Haff Disease From Chinamentioning

confidence: 99%

“…While the great majority of affected subjects fully recovered, serious complications could occur, including renal failure [14], multi-organ failure [19,23], prolonged myopathy [20], and even death from multi-organ failure [22]. …”

Section: Reports Of Haff Disease From Chinamentioning

confidence: 99%

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The Emergence and Epidemiology of Haff Disease in China

Chan

2016

Toxins

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Haff disease is a rare syndrome of unexplained myalgia and rhabdomyolysis occurring within 24 h of consumption of certain types of cooked freshwater fish or crustacean. It is caused by a yet unidentified heat-stable toxin. In the present review of published case studies and official press releases, the main objective is to report the emergence and epidemiology of Haff disease in China. Haff disease first occurred in Beijing in 2000 and in Lianzhou and Liannan, Guangdong Province in 2009. Subsequent outbreaks mostly occurred in the Jiangsu Province—Nanjing, Yangzhou, Huai’an, and Yancheng. Isolated outbreaks occurred in other cities since 2010—Shijiazhuang, Yueyang, Shanghai, Wuhu, Baoding, Shenzhen, and Hong Kong (imported cases from Shenzhen). Outbreaks occurred predominately in the summer. Crayfish accounted for almost all the outbreaks. Two large outbreaks occurred in Lianzhou and Liannan in 2009 (n = 54) after eating pomfrets and in Nanjing in 2010 (n = 42) after eating crayfish. Other reports or outbreaks involved only 1–9 subjects (median 2 subjects). Variability in individual susceptibility and attack rates were noted, with many subjects remaining asymptomatic despite sharing the same seafood meal as the index cases. Adults were predominately involved. Symptoms occurred within 3–20 h of seafood ingestion, including myalgia, weakness, and, less frequently, nausea, vomiting, abdominal pain, and diarrhea. Myalgia and muscle weakness should normally subside within 2–3 days. Serum creatine phosphokinase became normal within 5–6 days. Abnormal renal function was uncommon. Serious complications (renal failure, multi-organ failure, and prolonged myopathy) and death were rare. In any subjects with unexplained myalgia and rhabdomyolysis, seafood consumption should be included in the history. All suspected cases of Haff disease, including milder presentations, should be reported to public health authorities.

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Section: Discussionmentioning

confidence: 99%

Section: Reports Of Haff Disease From Chinamentioning

confidence: 99%

Section: Reports Of Haff Disease From Chinamentioning

confidence: 99%

Section: Reports Of Haff Disease From Chinamentioning

confidence: 99%

Section: Reports Of Haff Disease From Chinamentioning

confidence: 99%

See 3 more Smart Citations

The Emergence and Epidemiology of Haff Disease in China

Chan

2016

Toxins

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Rhabdomyolysis following fish consumption: a contained outbreak of Haff Disease in São Paulo

Almeida

Gushken

Abregu-Diaz

et al. 2019

The Brazilian Journal of Infectious Diseases

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Spread of alimentary-toxic paroxysmal myoglobinuria-haff disease (literature review)

Glazunova¹,

Musina²,

Yurchenko³

et al. 2021

E3S Web Conf.

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In 1924, Haff disease was first detected in East Prussia. Till now, cases of Haff disease have been recorded in Sweden, Russia, the United States, China, Brazil, Japan, and China among people and animals. During the last 40 years, there has been a significant expansion in the geographical range of Haff disease. From 1924 to 2019, 31 outbreaks were recorded in various parts of the world. The total number of victims was about 3,000 people. In Russia, the last cases of human disease were registered in 2019-2020. In fact, the source of the toxin is fish (crucian carp, carp, pike, burbot, walleye, perch, ruff, ide, yellowtail, black sea bass, eel, silver dollar, brown paku, red paku, cowfish, etc.) or crayfish. Today, the problem of the disease etiology has not been solved; the toxin with the corresponding features has not been isolated, and as a result, causal and pathogenetic treatment of alimentary-toxic paroxysmal myoglobinuria has not been developed. Over this period, several hypotheses were made that are leading in the study of the etiology of the occurrence of Haff disease (thiaminase theory, tannic, arachidonic). This disease-causing substance is known to be heat-resistant and break down the metabolism of skeletal muscles, resulting in the release of myoglobin, which disorders kidney function. It has also been found that toxic substances themselves gradually resolve from the fish, according to its diet (depending on what prevails - plankton, zooplankton or larvae, mollusks, crustaceans). For finding out the origin of the disease, it is essential to conduct comprehensive research by biologists, hydrologists, doctors, and veterinarians.

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Haff disease complicated by multiple organ failure after crayfish consumption: a case study

Cited by 26 publications

References 7 publications

The Emergence and Epidemiology of Haff Disease in China

The Emergence and Epidemiology of Haff Disease in China

Rhabdomyolysis following fish consumption: a contained outbreak of Haff Disease in São Paulo

Spread of alimentary-toxic paroxysmal myoglobinuria-haff disease (literature review)

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