Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients

Sim, Christina Poh Choo; Wee, Joseph; Xu, Ying; Cheung, Yin‐Bun; Soong, Yoke Lim; Manton, David J.

doi:10.1007/s00784-014-1318-y

Cited by 18 publications

(8 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies 11,37) demonstrating that adjunct use of CPP-ACP with stannous fluorides achieved significantly clinical advantages over CPP-ACP or fluorides alone in reducing the progression of radiation-caries in patients with NPC, which was consistent with our study. In a randomized clinical trial 11) of 24 NPC patients, the patients treated with both CPP-ACP and fluorides were underwent lower progressive caries behavior after a follow-up period of 3 months, which confirmed that the simultaneous application of CPP-ACP with fluorides has synergistic effects in preventing radiation-caries. In the presence of fluoride, CPP-ACP mixed with fluoride ions to form a new complex: casein phosphopeptideamorphous calcium fluoride phosphate (CPP-ACFP).…”

Section: Discussionsupporting

confidence: 91%

“…However, the reported anti-caries efficacy of CPP-ACP in comparison with traditional fluorides was controversial 7) . In a randomized clinical trial 11) of 24 patients with nasopharyngeal carcinoma (NPC), it was found that patients with CPP-ACP plus fluorides showed lower caries progressive behavior than those with fluorides alone. However, this synergistic remineralization effects of fluorides and CPP-ACP was not observed in other studies 12,13) .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of different anti-caries procedures on microhardness and micromorphology of irradiated permanent enamel

Geng

Gao

2020

Dent. Mater. J.

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effects of different anti-caries procedures on microhardness and micromorphology of irradiated permanent enamel

Geng

Gao

2020

Dent. Mater. J.

View full text Add to dashboard Cite

show abstract

“…Traditional caries-inhibition strategies are ineffective for patients with severe saliva reduction. For example, in an in vivo study, casein phosphopeptide ACP (CPP-ACP) failed to prevent radiation caries 112 . Therefore, there is a great need for new remineralization strategies that are effective in an acidic and Ca and P ion-deficient environment.…”

Section: Remineralization In An Extreme Acid Challenge Environment VImentioning

confidence: 99%

Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles

et al. 2019

View full text Add to dashboard Cite

Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents the first review on the cutting edge research of poly(amido amine) (PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP). PAMAM was excellent nucleation template, and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization. NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities. PAMAM +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates, superior acidneutralization, and ions release. Therefore, the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone. PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions. Besides, the long-term remineralization capability of PAMAM+NACP was established. After prolonged fluid challenge, the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration. Furthermore, the hardness of predemineralized dentin was increased back to that of healthy dentin, indicating a complete remineralization. Therefore, the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization, hardness increase, and caries-inhibition capabilities.

show abstract

“…The 2 studies in young children with CPP-ACP showed no significant added effect of CPP-ACP [Sitthisettapong et al, 2012;Plonka et al, 2013]. Two studies were done using patients with hyposalivation (and thus high risk for caries), and none of these favored the calcium test product [Hay and Thomson, 2002;Sim et al, 2015]. Out of the 7 studies done using white spot lesions developed around orthodontic brackets, 3 favored the calcium test agents CPP-ACP [Andersson et al, 2007;Bailey et al, 2009] and CPP-ACFP [Robertson et al, 2011].…”

Section: Casein Derivatives Coupled With Calcium (Cpp-acp Cpp-acfp mentioning

confidence: 99%

Enhancing Fluoride: Clinical Human Studies of Alternatives or Boosters for Caries Management

Fontana¹

2016

Caries Res

View full text Add to dashboard Cite

Dental caries remains a major public health problem, especially for certain high-risk population groups. The goal of this study was to assess the evidence regarding strategies meant to be used as alternatives or booster/supplements to fluoride for caries prevention and management. Articles were selected for inclusion if they had a prospective longitudinal design, with a fluoride control arm, and were conducted in human subjects. Of the included studies, 7/18 studies on calcium-based strategies favored the test product (the majority of studies included exposure of fluoride in all groups). All the arginine studies (8/8) included a combination of arginine and a calcium base, and concluded that this has the potential to significantly boost the performance of fluoride. The remaining included studies focused on the addition of microbial-related strategies to a fluoride-containing vehicle (2 xylitol studies and 1 study using a probiotic milk), and all favored the combination as a booster to fluoride. Thus, the current study did not identify evidence for any strategy to effectively be used as a substitute or alternative to fluoride, but identified some consistent evidence derived from the use of prebiotic strategies (primarily from use of arginine combined with calcium) to support their potential use to boost the mechanism of action of fluoride. Thus, fluoride-based strategies remain the standard for caries prevention and management, with some evidence that boosting the effects of fluoride by the use of prebiotic strategies is a promising possibility.

show abstract

Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients

Abstract: Adjunct use of CPP-ACP with stannous fluoride gel in irradiated NPC patients gave comparable results compared to stannous fluoride gel alone in reducing caries progression.

Cited by 18 publications

References 39 publications

Effects of different anti-caries procedures on microhardness and micromorphology of irradiated permanent enamel

Effects of different anti-caries procedures on microhardness and micromorphology of irradiated permanent enamel

Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles

Enhancing Fluoride: Clinical Human Studies of Alternatives or Boosters for Caries Management

Contact Info

Product

Resources

About