Can Ayahuasca and sleep loss change sexual performance in male rats?

Alvarenga, Tathiana A.; Polesel, Daniel Ninello; Matos, Gabriela; Garcia, Vanessa Athaíde; Costa, José Luiz; Tufik, Sérgio; Andersen, Mônica Levy

doi:10.1016/j.beproc.2014.09.024

Cited by 9 publications

(13 citation statements)

References 30 publications

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“…Moreover, the monoamines increased in the amygdala of rats, releasing inhibitory amino acids in the hippocampus, involving changes in monoamines and amino acids concentration [102], like glycine, with possible action on metabolism [26, 27]. In counterpart, ayahuasca exhibited effects on the sexual response, decreasing the number of mounts, intromissions, and ejaculations in Wistar rats [103].…”

Section: Chemistrymentioning

confidence: 99%

Ayahuasca: Uses, Phytochemical and Biological Activities

Estrella-Parra

Almanza-Perez

Alarcón-Aguilar

2019

Nat. Prod. Bioprospect.

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Ayahuasca (caapi, yajé), is a psychoactive brew from the Amazon Basin region of South America traditionally considered a "master plant." It is prepared as a decoction from Banisteriopsis caapi and Psychotria viridis, which it is thought that it stimulates creative thinking and visual creativity. Native healers of the Orinoco and Amazon basins have used traditionally ayahuasca as a healing tool for multiple purposes, particularly to treat psychological disorders in the patients, with some beneficial effects experimentally and clinically validated. Recently, several syncretic religions, as the "União de Vegetal" (UDV) group in Brazil, have been spread around the world. The use of ayahuasca has been popularized by internet and smart-shops, bringing the psychoactive substance to new highs, emerging new "ayahuasqueros." Ayahuasca has alkaloids as β-carbolines and dimethyltryptamines, which inhibit the monoamine oxidase and active the 5-HT 2A (5-hydroxytryptamine) receptor, respectively, resulting in hallucinations in the users. Ayahuasca induces a psychedelic change in the anteroposterior coupling of the electrophysiological brain oscillations in humans. Traditional ayahuasca beverage is generating pharmacological, commercial and spiritual interest among the scientific community, government people, and different populations worldwide. The goal of this article is to report about the uses, chemistry and biological activities of ayahuasca.

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Section: Chemistrymentioning

confidence: 99%

Ayahuasca: Uses, Phytochemical and Biological Activities

Estrella-Parra

Almanza-Perez

Alarcón-Aguilar

2019

Nat. Prod. Bioprospect.

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“…In the normal sleep group, ayahuasca at all doses reduced intromissions (p<0.05); in sleep-deprived animals, ayahuasca at 500μg/ml reduced intromissions (p<0.05) and lowered progesterone levels compared to non-sleep deprived of the same dose, and at 250μg/ml it increased intromissions (all p<0.05). No differences on testosterone and corticosterone were found (p>0.05) (Alvarenga et al, 2014).…”

Section: Miscellaneous (N=4)mentioning

confidence: 78%

“…Other relevant results identified in this review include the interaction of ayahuasca with opioids, the antinociceptive effects of ayahuasca, and the possible role of ayahuasca in regulating testosterone levels and influencing sexual performance upon stress (Alvarenga et al, 2014;Pires et al, 2018;Santos et al, 2017). While these studies bring attention to possible effects of ayahuasca on conditions that can be identified on traditional ayahuasca use, such as ayahuasca consumption under sleep deprivation or people that are under opioid medication usage, these results are still dependent on induvial studies, and further investigations are essential to clarify the nature of the effects better.…”

Section: Behavioural and Neurobiological Parametersmentioning

confidence: 99%

The current state of ayahuasca research in animal models: A systematic review

Daldegan‐Bueno

Simionato

Favaro

et al. 2023

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Previous experimental investigations of the behavioral effects of ayahuasca used acute or chronic administration protocols that did not reflect the use pattern of this beverage in humans ( 35 – 37 ). The distinguishing feature of our experimental protocol was the chronic intermittent exposure to ayahuasca that mimicked the use in a ritualistic context.…”

Section: Discussionmentioning

confidence: 99%

An ontogenic study of the behavioral effects of chronic intermittent exposure to ayahuasca in mice

Correa-Netto¹,

Masukawa²,

Nishide³

et al. 2017

Braz J Med Biol Res

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Ayahuasca is a beverage obtained from decoctions of the Banisteriopsis caapi plus Psychotria viridis. In religious contexts, ayahuasca is used by different age groups. However, little is known of the effects of ayahuasca during ontogenic development, particularly with regard to the functional characteristics of the central nervous system. Animal models are useful for studying the ontogenic effects of ayahuasca because they allow exclusion of the behavioral influence associated with the ritualistic use. We investigated the effects of exposure to ayahuasca (1.5 mL/kg, orally, twice a week) on memory and anxiety in C57BL/6 mice, with the post-natal day (PND) being used as the ontogenic criterion for classification: childhood (PND21 to PND35), adolescence (PND35 to PND63), adulthood (PND90-PND118), childhood-adolescence (PND21 to PND63), childhood-adulthood (PND21 to PND118) and adolescence-adulthood (PND35 to PND118). One day after the last ayahuasca exposure, the mice were subjected to the Morris water maze (MWM), open field and elevated plus maze tasks (EPM). Ayahuasca did not affect locomotion in the open field or open arms exploration in the EPM, but increased the risk assessment behavior in the childhood group. Ayahuasca did not cause any change in acquisition of spatial reference memory in the MWM task, but decreased the time spent on the platform quadrant during the test session in the adolescence group. These results suggest that, in mice, exposure to ayahuasca in childhood and adolescence promoted anxiety and memory impairment, respectively. However, these behavioral changes were not long-lasting since they were not observed in the childhood-adulthood and adolescence-adulthood groups.

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Can Ayahuasca and sleep loss change sexual performance in male rats?

Cited by 9 publications

References 30 publications

Ayahuasca: Uses, Phytochemical and Biological Activities

Ayahuasca: Uses, Phytochemical and Biological Activities

The current state of ayahuasca research in animal models: A systematic review

An ontogenic study of the behavioral effects of chronic intermittent exposure to ayahuasca in mice

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