The current state of ayahuasca research in animal models: A systematic review

Daldegan‐Bueno, Dimitri; Simionato, Natalia M.; Favaro, Vanessa Manchim; Maia, Lucas O.

doi:10.1016/j.pnpbp.2023.110738

Cited by 5 publications

(3 citation statements)

References 149 publications

(173 reference statements)

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“…Gable 26 estimates that a fatal dosage of DMT would be about 20 times higher than standard ayahuasca practice. A review of animal studies on ayahuasca toxicity supports the safety of ceremonial‐level doses, except for alterations in aorta parameters observed in one study 264 . Serotonin syndrome (SS) was only seen at doses significantly higher than those used in ceremonies 264 .…”

Section: Safety Considerationsmentioning

confidence: 91%

“…264 Serotonin syndrome (SS) was only seen at doses significantly higher than those used in ceremonies. 264 Overall, the therapeutic window for ayahuasca appears wide, with no acute or long-term toxicity reported in humans. 265 Ayahuasca has a low addiction potential 86 and cardiovascular risk.…”

Section: Safety Considerationsmentioning

confidence: 99%

“…A review of animal studies on ayahuasca toxicity supports the safety of ceremonial-level doses, except for alterations in aorta parameters observed in one study. 264 Serotonin syndrome (SS) was only seen at doses significantly higher than those used in ceremonies. 264 Overall, the therapeutic window for ayahuasca appears wide, with no acute or long-term toxicity reported in humans.…”

Section: Safety Considerationsmentioning

confidence: 99%

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Ayahuasca: A review of historical, pharmacological, and therapeutic aspects

Ruffell,

Crosland‐Wood,

Palmer

et al. 2023

PCN Reports

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Ayahuasca is a psychedelic plant brew originating from the Amazon rainforest. It is formed from two basic components, the Banisteriopsis caapi vine and a plant containing the potent psychedelic dimethyltryptamine (DMT), usually Psychotria viridis. Here we review the history of ayahuasca and describe recent work on its pharmacology, phenomenological responses, and clinical applications. There has been a significant increase in interest in ayahuasca since the turn of the millennium. Anecdotal evidence varies significantly, ranging from evangelical accounts to horror stories involving physical and psychological harm. The effects of the brew on personality and mental health outcomes are discussed in this review. Furthermore, phenomenological analyses of the ayahuasca experience are explored. Ayahuasca is a promising psychedelic agent that warrants greater empirical attention regarding its basic neurochemical mechanisms of action and potential therapeutic application.

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Section: Safety Considerationsmentioning

confidence: 91%

Section: Safety Considerationsmentioning

confidence: 99%

Section: Safety Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

Ayahuasca: A review of historical, pharmacological, and therapeutic aspects

Ruffell,

Crosland‐Wood,

Palmer

et al. 2023

PCN Reports

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Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain

Lauria,

Gomes,

Abreu

et al. 2024

Journal of Ethnopharmacology

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Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT_2A and 5‐HT_1A receptors

Werle,

Nascimento,

dos Santos

et al. 2024

British J Pharmacology

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Background and PurposeAyahuasca (AYA) is a botanical psychedelic with promising results in observational and small clinical trials for depression, trauma and drug use disorders. Its psychoactive effects primarily stem from N,N‐dimethyltryptamine (DMT). However, there is a lack of research on how and where AYA acts in the brain. This study addressed these questions by examining the extinction of aversive memories in AYA‐treated rats.Experimental ApproachWe focused on the 5‐HT1A and 5‐HT2A receptors, as DMT exhibits a high affinity for both of them, along with the infralimbic cortex in which activity and plasticity play crucial roles in regulating the mnemonic process under analysis.Key ResultsA single oral treatment with AYA containing 0.3 mg·kg−1 of DMT increased the within‐session extinction of contextual freezing behaviour without affecting its recall. This protocol, when repeated twice on consecutive days, enhanced extinction recall. These effects were consistent for both 1‐ and 21‐day‐old memories in males and females. AYA effects on fear extinction were independent of changes in anxiety and general exploratory activity: AYA‐ and vehicle‐treated animals showed no differences when tested in the elevated plus‐maze. The 5‐HT2A receptor antagonist MDL‐11,939 and the 5‐HT1A receptor antagonist WAY‐100635 infused into the infralimbic cortex respectively blocked within‐ and between‐session fear extinction effects resulting from repeated oral administration of AYA.Conclusion and ImplicationsOur findings highlight complementary mechanisms by which AYA facilitates the behavioural suppression of aversive memories in the rat infralimbic cortex. These results suggest potential beneficial effects of AYA or DMT in stress‐related disorders.

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The current state of ayahuasca research in animal models: A systematic review

Cited by 5 publications

References 149 publications

Ayahuasca: A review of historical, pharmacological, and therapeutic aspects

Ayahuasca: A review of historical, pharmacological, and therapeutic aspects

Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain

Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT_2A and 5‐HT_1A receptors

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The current state of ayahuasca research in animal models: A systematic review

Cited by 5 publications

References 149 publications

Ayahuasca: A review of historical, pharmacological, and therapeutic aspects

Ayahuasca: A review of historical, pharmacological, and therapeutic aspects

Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain

Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT2A and 5‐HT1A receptors

Contact Info

Product

Resources

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Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT_2A and 5‐HT_1A receptors