Activity of coenzyme Q₁₀(Q-Ter multicomposite) on recovery time in noise-induced hearing loss

Abstract

A potential consequence of exposure to noise is a temporary reduction in auditory sensitivity known as temporary threshold shift (TTS), which mainly depends on the intensity and duration of exposure to the noise. Recovery time is related to the amount of initial hearing loss, and the most recovery takes place during the first 15 min following exposure. This study evaluated the efficacy in otoprotection against noise-induced hearing loss of an orally administrated food supplement containing coenzyme Q 10 -Ter. This water-soluble formulation of coenzyme Q 10 shows better bioavailability than the native form and has been found to have a protective effect on outer hair cells after exposure to noise in animal models. Thirty volunteers were enrolled, and the right ear of each subject was exposed to a narrow-band noise centered at 3 kHz for 10 min at the intensity of 90 dB HL. In the 30 subjects enrolled, TTS was evaluated after 2, 15, and 30 min and the recovery time was recorded in each subject. The longest recovery time was 45 min. Among the 18 subjects who underwent a second test after treatment with Q-Ter, the mean recovery time was 31.43 min. The results of the present study show that 30 days' treatment with Q-Ter can aid faster recovery after exposure to noise (P < 0.0001). The reduction in the recovery time following treatment can be explained by Q-Ter-mediated improvement of the outer hair cells' response to oxidative stress.

Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study

“…Coenzyme Q10 is a potent antioxidant by either directly scavenging free radicals or recycling and regenerating other antioxidants [ 33 , 34 ]. Noteworthy, Qter ® showed enhanced bioavailability with respect to the native form [35] and demonstrated a protective effect in preventing damage to the outer hair cells of the cochlea following noise exposure [ 8 , 10 , 12 ]. Likewise, Ginkgo biloba extract has demonstrated to prevent gentamicin and cisplatin-induced ototoxicity in both in-vitro and animal models [ 36 , 37 ], as well as to protect cochlear hair cells against ototoxicity induced by gentamicin through the reduction of ROS and nitric oxide-related apoptosis [37] .…”

“…Antioxidants, ROS scavengers, or anti-inflammatory drugs may thus represent potential therapeutic options to prevent platinum-associated ototoxicity. Among these, the supplementation of water-soluble coenzyme Q10 (Q10 terclatrate − QTer ® ) was already able to prevent in animals [ 7 , 8 , 9 , 10 ] and human volunteers [ 11 , 12 ] both noise-induced hear loss (NIHL) and gentamycin mediated ototoxicity, which have a similar ROS mediated etiology. Moreover, the same strategy was reported to exert significant improvements of hearing thresholds at 1000 Hz, 2000 Hz, 4000 Hz, and 8000 Hz in patients with presbycusis [ 13 , 14 ].…”

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

“…Other antioxidants that can potentially play a protective role against noise-induced cochlear trauma include ginseng [172], co-enzyme Q10 [177], as well as several vitamins, such as vitamin A [178], vitamin C [179, 180], vitamin E [181, 182], and vitamin B12 [183]. Studies in animals showed a protective benefit from combination antioxidant treatment, such as magnesium and vitamin A, C, and E [184], possibly due to synergistic effects [185–187], These studies were mainly performed in animals or in small groups of humans and the results should be considered preliminary.…”

Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

“…Protection was achieved only using the 10-day pre-noise dosing strategy; no reductions in TTS were achieved with 1-hour pre-noise dosing. Finally, Staffa et al [2014] reported reductions in TTS induced by unilateral exposure to narrow-band noise using 30-day pre-treatment with coenzyme Q10, in addition to 8 other active agents including lactium, melatonin, choline, Ginkgo biloba, and vitamins E, B 1 , B 6 , and B 12 . When the treatment period was shorter (7 days pre-noise) and the supplement included only coenzyme Q10, TTS induced by white noise was not reduced although noise-induced decreases in distortion product otoacoustic emission (DPOAE) amplitude were ameliorated [Fetoni et al, 2009].…”