Vitamin D deficiency decreases adiposity in rats and causes altered expression of uncoupling proteins and steroid receptor coactivator3

Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health

“…When the deranged signaling of 1,25(OH) 2 D 3 is investigated, it must be considered that the insufficiency of vitamin D and the loss of the receptor have some similar but partly distinct consequences. The hypocalcemic phenotype shared by vitamin D deficiency and VDR knockout models can be reversed by a high-calcium diet [ 25 ], but even at very low levels of 1,25(OH) 2 D 3 , the VDR can still operate in a ligand-independent modality [ 26 , 27 ] or can respond to other molecules [ 28 , 29 , 30 ]. Therefore, in order to analyze fully and unambiguously the perturbation of 1,25(OH) 2 D 3 signaling, the best approach is to delete the receptor, and we followed this line of investigation.…”

Vitamin D deficiency impairs glucose-stimulated insulin secretion and increases insulin resistance by reducing PPAR-γ expression in nonobese Type 2 diabetic rats

“…There are some inconsistent results on the association of vitamin D status and fat mass in human and animal studies [36][37][38][39]. Cross-sectional and prospective human studies have revealed a beneficial effect of vitamin D for decreasing visceral fat mass [9,36] but randomized clinical trials of vitamin D supplementation have shown inconsistent effects on body fat mass in obese adults [37,38].…”

“…Vitamin D deficiency is associated with the development of type 2 diabetes and with increased insulin resistance and impaired insulin secretion in human and animal studies [36][37][38][39][40]. Cross-sectional and prospective studies have revealed that vitamin D deficiency is involved in the derangement of insulin resistance and insulin secretion which is commonly involved in the etiology of type 2 diabetes mellitus [9,[16][17][18].…”

Effects of maternal vitamin D3 during pregnancy on FASN and LIPE mRNA expression in offspring pigs

“…These results are in accordance with previous reports, Yao et al (2015) demonstrated that obesity is associated with vitamin D deficiency, and vitamin D suppresses adipogenesis. Whereas, Bhat et al (2014) observed that vitamin D-deficient rats decreased visceral fat content and FASN and PPARγ expression. Inconsistent research results may be due to differential adipose tissue and species of animals.…”