Vitamin D deficiency impairs glucose-stimulated insulin secretion and increases insulin resistance by reducing PPAR-γ expression in nonobese Type 2 diabetic rats

Park, Sunmin; Kim, Da Sol; Kang, Suna

doi:10.1016/j.jnutbio.2015.09.013

Cited by 85 publications

(77 citation statements)

References 49 publications

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“…In addition to conventional insulin signalling, PPAR‐γ also has an important role in regulating insulin sensitivity and glucose transport (Park et al ., ). PPAR‐γ knockout mice were reported to exhibit aggravated insulin resistance due to an abnormal insulin sensitivity in muscle and adipose tissues (He et al ., ; Hevener et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat

Zhou

Zhang

Zou

et al. 2018

British J Pharmacology

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Background and Purpose Sulfonylureas (SUs) have been suggested to have an insulin‐independent blood glucose‐decreasing activity due to an extrapancreatic effect. However, a lack of adequate in vivo evidence makes this statement controversial. Here, we aimed to evaluate whether glimepiride has extrapancreatic blood glucose‐lowering activity in vivo. Experimental Approach Sulfonylurea receptor 1 deficient (SUR1−/−) rats were created by means of transcription activator‐like effector nucleases (TALEN)‐mediated gene targeting technology. Type 2 diabetic models were established by feeding a high‐fat diet and administering a low‐dose of streptozotocin. These rats were then randomly divided into four groups: glimepiride, gliclazide, metformin and saline. All rats were treated for 2 weeks. Key Results Glimepiride decreased blood glucose levels and increased insulin sensitivity without elevating insulin levels. Gliclazide showed similar effects as glimepiride. Both agents were weaker than metformin. Further mechanistic investigations revealed that glimepiride increased hepatic glycogen synthesis and decreased gluconeogenesis, which were accompanied by the activation of Akt in the liver. Moreover, glimepiride increased both total and membrane glucose transporter 4 (GLUT4) levels in muscle and fat, which might be attributed to insulin receptor‐independent IRS1/Akt activation. Conclusion and Implications Glimepiride possesses an extrapancreatic blood glucose‐lowering effect in vivo, which might be attributed to its direct effect on insulin‐sensitive tissues. Therefore, the combination of glimepiride with multiple insulin injections should not be excluded per se.

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Section: Discussionmentioning

confidence: 97%

Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat

Zhou

Zhang

Zou

et al. 2018

British J Pharmacology

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“…The ginsenosides are not detected in the blood after ginseng and ginsenoside Re treatment due to poor systemic bioavailability of ginsenosides [20]. Shiitake mushroom, which rich in β-glucans and vitamin D, also has anti-diabetic activities [5,33,34]. β -glucan changes the gut microbiomes that may be associated with improving insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…Red ginseng and ginsenoside Re, Rb1, and Rb2, its active ingredients, have demonstrated an antidiabetic action in in vitro, animal, and clinical studies. Ultraviolet-irradiated shiitake mushroom (Lentinus edodes), polysaccharides, has antioxidant activity [11] and it can be a good source for vitamin D (V-D) in humans [5]. V-D exerts anti-diabetic activity by improving insulin secretion and insulin sensitivity [5].…”

Section: Introductionmentioning

confidence: 99%

“…Ultraviolet-irradiated shiitake mushroom (Lentinus edodes), polysaccharides, has antioxidant activity [11] and it can be a good source for vitamin D (V-D) in humans [5]. V-D exerts anti-diabetic activity by improving insulin secretion and insulin sensitivity [5]. The water or ethanol extracts of Aronia, red ginseng and shiitake mushroom have been well studied, but the whole foods, including dietary fiber, may be better for inducing changes to the gut microbiome that influence glucose metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Combination of Aronia, Red Ginseng and Shiitake Mushroom Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

Yang¹,

Kim²,

Kwon³

et al. 2018

Preprint

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The combination of freeze-dried aronia, red ginseng, ultraviolet-irradiated shiitake mushroom and natokinase (AGM; 3.4: 4.1: 2.4: 0.1) was examined to evaluate its effects on insulin resistance, insulin secretion and gut microbiome in a non-obese type 2 diabetic animal model. Pancreatectomized (Px) rats were provided high fat diets supplemented with either of 1) 0.5 g AGM (AGM-L), 2) 1 g AGM (AGM-H), 3) 1 g dextrin (control), or 4) 1g dextrin with 120 mg metformin (positive-control) per kg body weight for 12 weeks. AGM (1 g) contained 6.22 mg cyanidin-3-galactose, 2.5 mg ginsenoside Rg3 and 0.6 mg β-glucan. Px rats had decreased bone mineral density in the lumbar spine and femur and lean body mass in the hip and leg compared to the normal-control and AGM-L and AGM-H prevented the decrease. Visceral fat mass was lower in the control group than the normal-control group and its decrease was smaller by AGM-L and AGM-H. HOMA-IR was lower in descending order of the control, positive-control, AGM-L, AGM-H and normal-control groups. Glucose tolerance was deteriorated in the control group and it was improved by AGM-L and AGM-H more than in the positive-control group.Glucose tolerance is associated with insulin resistance and insulin secretion. Insulin tolerance indicated insulin resistance was highly impaired in diabetic rats, but it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Insulin secretion capacity, measured by hyperglycemic clamp, was much lower in the control group than the normalcontrol group and it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Diabetes modulated the composition of gut microbiome and AMG prevented the modulation of gut microbiome. In conclusion, AGM improved glucose metabolism by potentiating insulin secretion and reducing insulin resistance in insulin deficient type 2 diabetic rats. The improvement of diabetic status alleviated body composition changes and prevented changes of gut microbiome composition.Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

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“…Estudios previos en modelos animales han sugerido que la vitamina D podría promover directamente la estimulación de la expresión del receptor de insulina en las células β y mediar indirectamente en la regulación del calcio extracelular y el mantenimiento de la afluencia normal de calcio a estas células (11)(12)(13); sin embargo, los resultados sobre su eficacia como una alternativa terapéutica en estados hiperglicémicos aún son contradictorios y poco estudiados. Por ende, el objetivo del presente estudio es determinar el efecto de la vitamina D 2 y vitamina D 3 en el control de la glicemia en un modelo murino de inducción de hiperglicemia experimental.…”

Section: Introductionunclassified

Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas

Jokada¹,

Arroyo-Acevedo²,

Chávez-Rimache³

et al. 2017

Rev. per. med. integr.

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Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas. Rev Peru Med Integrativa.2017;2(3):798-802. Historia del artículo Información del artículo ResumenObjetivo. Determinar el efecto del Ergocalciferol (vitamina D 2 ) y el colecalciferol (vitamina D 3 ) sobre el control de la glicemia en ratas. Materiales y métodos. Estudio experimental. Se utilizó 48 ratas machos Wistar de 12 semanas de edad, con un peso de 200 ± 50 g, distribuidas de manera aleatoria en ocho grupos de seis: control negativo (suero fisiológico a 2 mL/dieta balanceada); control positivo (suero fisiológico a 2 mL/dieta modificada); EXP 1 (vitamina D 2 a 10000 UI/kg /dieta modificada); EXP 2 (vitamina D 2 a 35000 UI/kg /dieta modificada); EXP 3 (vitamina D 2 a 70000 UI/kg /dieta modificada); EXP 4 (vitamina D 3 a 10000 UI/kg /dieta modificada); EXP 5 (vitamina D 3 a 35000 UI/kg /dieta modificada), y EXP 6 (vitamina D 3 a 70000 UI/kg /dieta modificada); se administraron dos tipos de dietas (dieta balanceada y dieta modificada a base de colesterol y fructuosa) y vitaminas D 2 y D 3 de manera conjunta durante las 13 semanas de estudio. Resultados. El promedio de glicemia del grupo control negativo (CN) fue 80,17 mg/dL; en los grupos experimentales fueron: 91,17 mg/dL (EXP1); 90,17 mg/dL (EXP2); 87,67 mg/dL (EXP3); 91,67 mg/dL (EXP4); 88,33 mg/dL (EXP5); 81,83 mg/dL (EXP6), y en el grupo control positivo (CP) fue 134,84 mg/dL. Conclusión. Los grupos con dieta modificada y que recibieron ergocalciferol (vitamina D 2 ) o colecalciferol (vitamina D 3 ) mostraron niveles menores de glicemia en comparación con los que no recibieron suplementación, no habiendo diferencias significativas entre la utilización de algún tipo de vitamina D o las dosis de 35000 y 70000 UI. Palabras clave: Ergocalciferoles; Hiperglicemia; Experimentación Animal (Fuente: DeCS). Effect of ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) on glycemic control in rats AbstractObjective. Determine the effect of Ergocalciferol (Vitamin D 2 ) and Cholecalciferol (Vitamin D 3 ) on glycemic control in rats. Materials and Methods. Experimental study. 48 male Wistar rats aged 12 weeks of age were used, which weighted 200 ± 50 g, distributed randomly into eight groups of 6 members each one: negative control (saline solution at 2 mL/ balanced diet), positive control (saline solution at 2 mL/modified diet), EXP 1 (Vitamin D 2 at 10000 IU/kg / modified diet), EXP 2 (vitamin D 2 at 35000 IU/kg / modified diet), EXP 3 (Vitamin D 2 at 70000 IU/kg / modified diet), EXP 4 (Vitamin D 3 at 10000 IU/kg / modified diet), EXP 5 (Vitamin D 3 at 35000 IU/kg / modified diet), EXP 6 (Vitamin D 3 at 70000 IU/kg / modified diet); two types of diets (balanced diet and modified diet based on cholesterol and fructose) and vitamins D 2 and D 3 were administered together during the 13 weeks of study. Results. The average of glycemia in the negative control group (NC) was 80.17 mg/dL; in the experimental groups were: 91.17 mg/dL (EXP1), 90.17 mg...

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Vitamin D deficiency impairs glucose-stimulated insulin secretion and increases insulin resistance by reducing PPAR-γ expression in nonobese Type 2 diabetic rats

Cited by 85 publications

References 49 publications

Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat

Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat

Combination of Aronia, Red Ginseng and Shiitake Mushroom Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas

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