Is Vitamin D Deficiency a Risk Factor for Respiratory Distress Syndrome?

Ataseven, Fevzi; Aygün, Canan; Okuyucu, Ali; Bedir, Abdülkerim; Küçük, Yasemin; Küçüködük, Şükrü

doi:10.1024/0300-9831/a000165

Cited by 42 publications

(37 citation statements)

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“…24–26 Preterm infants with lower 25(OH) vitamin D are also at higher risk of acute respiratory morbidity 26, 27 and BPD. 28 ELGAN are at high risk for low serum vitamin D concentrations not only because transfer of vitamin D occurs later in gestation, 10, 11 but perhaps also because of maternal insufficiency.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of 3 Vitamin D Dosing Regimens in Extremely Preterm Infants: A Randomized Controlled Trial

Fort

Salas

Nicola

et al. 2016

The Journal of Pediatrics

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Objective To determine the optimal dose of vitamin D supplementation to achieve biochemical vitamin D sufficiency in extremely low gestational age newborns in a masked randomized controlled trial. Study design 100 infants 23 0/7 to 27 6/7 weeks gestation were randomized to vitamin D intakes of placebo (n=36), 200 IU (n=34), and 800 IU/day (n=30) (approximating 200, 400, or 1000 IU/day, respectively, when vitamin D routinely included in parenteral or enteral nutrition is included). The primary outcomes were serum 25 (OH) vitamin D concentrations on postnatal day 28 and the number of days alive and off respiratory support in the first 28 days. Results At birth, 67% of infants had 25(OH) vitamin D < 20 ng/mL suggesting biochemical vitamin D deficiency. Vitamin D concentrations on day 28 were (Median [25th–75th centiles], ng/mL): Placebo: 22 [13–47], 200 IU: 39 [26–57], 800 IU: 84.5 [52–99], p < 0.001. There were no differences in days alive and off respiratory support (Median (25th–75th centiles), days: Placebo: 1 (0–11), 200 IU: 0 (0–8), 800 IU: 0.5 (0–22), p=0.63), or other respiratory outcomes among groups. Conclusion At birth, most extremely preterm infants have biochemical vitamin D deficiency. This biochemical deficiency is reduced on day 28 by supplementation with 200 IU/day and prevented by 800 IU/day. Larger trials are required to determine if resolution of biochemical vitamin D deficiency improves clinical outcomes. ClinicalTrials.gov: NCT01600430 Trial registration ClinicalTrials.gov: NCT01600430

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Section: Discussionmentioning

confidence: 99%

A Comparison of 3 Vitamin D Dosing Regimens in Extremely Preterm Infants: A Randomized Controlled Trial

Fort

Salas

Nicola

et al. 2016

The Journal of Pediatrics

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“…Todos tuvieron niveles de 25 (OH) D menores de 75 nmol/L. No se encontró correlación entre edad gestacional y estatus de vitamina D. En un análisis no ajustado, el SDR se observó en un 28% del grupo con niveles menores a 25 nmol/L comparado con un 14% en aquellos con valores superiores, reduciendo la frecuencia de SDR en 3.34 veces en aquellos con los valores más altos 17 . Finalmente, en un estudio observacional, Koroglu y cols., encontraron un incremento promedio de 4 veces en el riesgo de desarrollar de DBP en comparación a aquellos sin este hallazgo 18 .…”

Section: Maduración Pulmonarunclassified

Vitamina D y enfermedades respiratorias pediátricas

Zenteno

et al. 2019

Rev Chil Ped

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El mejor entendimiento sobre la actividad global de la vitamina D, ha llevado a una intensa búsqueda de sus implicancias en enfermedades no esqueléticas. En este artículo se presenta una revisión actualizada de la relación entre la vitamina D y la patología respiratoria pediátrica. Se realizó una búsqueda bibliográfica en PUBMED utilizando términos libres y MESH: vitamina D, enfermedades del sistema respiratorio, asma, bronquiolitis. Se seleccionó estudios en humanos menores de 18 años y animales, publicados en inglés y español hasta el 2017. Se encontraron 507 artículos, de los cuales se incluyeron 43. Evidencia indirecta apunta hacia un rol de la vitamina D y la maduración pulmonar fetal. En relación a la patología pulmonar pediátrica, los estudios son escasos y poco concluyentes. Nuevos meta – análisis, con evaluación individualizada de los participantes, muestran un importante rol protector de la suplementación en la prevención de exacerbaciones asmáticas severas e infecciones virales agudas. En bronquiolitis los resultados son contradictorios, sin relación clara entre niveles plasmáticos y severidad. No existe suficiente evidencia que evalué los beneficios en fibrosis quística y tuberculosis. Recientemente se ha propuesto una relación directa entre la severidad de los trastornos respiratorios del sueño y los niveles plasmáticos de vitamina D, aunque se desconoce los mecanismos exactos involucrados a esta asociación. La información actual permite suponer que la suplementación de vitamina D puede representar una estrategia costo – efectiva en la reducción de importantes causas de morbimortalidad infantil.

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“…16 In another study conducted by Ataseven et al, respiratory distress syndrome was more common with severe (28%) compared to mild-moderate 25(OH)D deficiency (14%) (p <0.05). 17…”

Section: Neonatal Complicationsmentioning

confidence: 99%

Evaluation of vitamin D levels in term pregnancy and its obstetric outcome in Indian women

Ciryam

Munikrishna

Dayanand

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Vitamin D deficiency is currently a global pandemic affecting all age groups. Vitamin D is considered a fundamental hormone in calcium homeostasis and bone health. Risk of vitamin D deficiency increases during pregnancy due to increased maternal and fetal demands and altered vitamin D metabolism. Recently, maternal vitamin D deficiency has been linked to adverse pregnancy outcomes, including preeclampsia, gestational diabetes, fetal growth restriction and preterm birth. Adequate vitamin D status appears to be relevant to health at all ages, and even in prenatal life.Methods: This is a cross sectional, observational study conducted in the department of obstetrics and gynaecology at R. L. Jalappa Hospital. A total number of 160 subjects were included. 5 ml of venous blood was collected and was centrifuged at 3000 rpm and stored at - 80°C till analysis. Analysis of 25-hydroxy Vitamin D was done using ELISA.Results: Majority of the subjects were vitamin D deficient (81.87%) and 12.5% were vitamin D insufficient and only 5.63% were vitamin D sufficient. The prevalence of vitamin D deficiency was more among primigravidas (85.6%) and was associated with higher rates of caesarean section (92.4%). High prevalence of vitamin D deficiency was seen in lower middle socioeconomic class (62.5%). Maternal vitamin D deficiency was associated low birth weight of neonates (100%).Conclusions: In this study it was concluded that majority of subjects were vitamin D deficient and belonged to lower middle socioeconomic class. Majority of this subjects who underwent caesarean section were vitamin D deficient. Vitamin D deficiency was associated only with low birth weight of neonates and no other adverse obstetric outcome.

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Is Vitamin D Deficiency a Risk Factor for Respiratory Distress Syndrome?

Cited by 42 publications

References 0 publications

A Comparison of 3 Vitamin D Dosing Regimens in Extremely Preterm Infants: A Randomized Controlled Trial

A Comparison of 3 Vitamin D Dosing Regimens in Extremely Preterm Infants: A Randomized Controlled Trial

Vitamina D y enfermedades respiratorias pediátricas

Evaluation of vitamin D levels in term pregnancy and its obstetric outcome in Indian women

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