Effect of antibiotic use and mold exposure in infancy on allergic rhinitis in susceptible adolescents

Yang, Song I; Lee, Eun; Jung, Young Ho; Kim, Hyung Young; Seo, Ju Hee; Kwon, Ji Won; Kim, Byoung Ju; Kim, Hyo Bin; Lee, So Yeon; Jang, Gwang Cheon; Kim, Woo Kyung; Shim, Jung Yeon; Kang, Mi Jin; Yu, Ho Song; Hong, Soo Jong

doi:10.1016/j.anai.2014.05.019

Cited by 21 publications

(35 citation statements)

References 59 publications

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“…Our findings help clarify the association between antibiotic use and other allergic diseases, particularly allergic rhinitis, for which prior studies have reported inconsistent results. [18,[20][21][22][28][29][30][31] Our findings are similar to those of the only other study of allergic rhinitis and antibiotic use that did not depend on selfreport [21]. As with our food allergy findings, associations were stronger in children diagnosed at a younger age.…”

Section: Discussionsupporting

confidence: 89%

“…In the last decade, prescriptions of broad‐spectrum antibiotics went up 49% in children up to 5 years of age and doubled in children from 5 to 17 years of age, concomitant with the increasing prevalence of allergies . Differences in the gut microbiota have been observed between children with allergic conditions and non‐allergic children, although these studies have not evaluated whether these differences could be due to earlier disparities in antibiotic use . Literature demonstrates an association between antibiotic use and asthma , but few studies have examined early‐life antibiotic use and other atopic diseases.…”

Section: Introductionmentioning

confidence: 99%

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Early‐life antibiotic use and subsequent diagnosis of food allergy and allergic diseases

Hirsch

Pollak

Glass

et al. 2016

Clin Experimental Allergy

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Background Antibiotic use in early life has been linked to disruptions in the microbiome. Such changes can disturb immune system development. Differences have been observed in the microbiota of children with and without allergies, but there have been few studies on antibiotic use and allergic disease. Objective We evaluated associations of early-life antibiotic use with subsequent occurrence of food allergy and other allergies in childhood using electronic health record data. Methods We used longitudinal data on 30,060 children up to age 7 years from Geisinger Clinic’s electronic health record to conduct a sex and age matched case-control study to evaluate the association between antibiotic use and milk allergy, non-milk food allergies, and other allergies. For each outcome, we estimated conditional logistic regression models adjusting for race/ethnicity, history of Medical Assistance, and mode of birth delivery. Models were repeated separately for penicillins, cephalosporins, and macrolides. Results There were 484 milk allergy cases, 598 non-milk food allergy cases, and 3652 other allergy cases. Children with three or more antibiotic orders had a greater odds of milk allergy (odds ratio; 95% confidence interval) (1.78; 1.28–2.48), non-milk food allergy (1.65; 1.27–2.14), and other allergies (3.07; 2.72–3.46) compared to children with no antibiotic orders. Associations were strongest at younger ages and differed by antibiotic class. Conclusions and Clinical Relevance We observed associations between antibiotic orders and allergic diseases, providing evidence of a potentially modifiable clinical practice associated with pediatric allergic disease. Differences by antibiotic class should be further explored, as this knowledge could inform pediatric treatment decisions.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Early‐life antibiotic use and subsequent diagnosis of food allergy and allergic diseases

Hirsch

Pollak

Glass

et al. 2016

Clin Experimental Allergy

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“…1.030-4.805), 환삼덩굴 3.398 (1.217-9.429), 고양이 2.695(1.353- 5.367) 등이 중요한 알레르겐이었다(Table 5). 천식의 경우 부모의 천식 진단은 천식 발생의 중요한 위험 인자 이고,17) 알레르기비염의 경우도 다른 연구들에서 알레르기비염 가 족력과 알레르기비염 발생과의 연관성을 보고하였다 8,10,12,13). 최근 알레르기 질환 발생에 있어 영아기 항생제 사용이 영향을 미친다는 여러 연구 보고들이 있었다 18,19).…”

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The prevalence and risk factors of allergic rhinitis from a nationwide study of Korean elementary, middle, and high school students

Kim

Seo²,

Kwon

et al. 2015

Allergy Asthma Respir Dis

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Purpose: We investigated the prevalence and risk factors of allergic rhinitis (AR), nationwide in random children and adolescents of Korea. Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire survey was done in 1,820 children from elementary, middle, and high school nationwide in Korea. The subjects were selected by the stratifying sampling method by school grade and five regions. Current AR was defined as having AR symptoms during the last 12 months with a history of physician-diagnosed AR. Skin prick tests for 18 common allergens were performed. Results: The number of males was 945, and that of females was 875. The mean age of the patients was 12.61± 3.40 years. The prevalence of current AR and atopic current AR were 29.0% and 18.7%, respectively. Risk factors for current AR were male (adjusted odds ratio [aOR], 1.486; 95% confidence interval [CI], 1.189-1.856), family history of paternal AR (aOR, 3.208; 95% CI, 2.460-4.182), family history of maternal AR (aOR, 3.138; 95% CI, 2.446-4.025), antibiotic use in infancy (aOR, 1.547; 95% CI, 1.228-1.949), mold exposure during infancy (aOR, 1.416; 95% CI, 1.103-1.819), mold exposure during the last 12 months (aOR, 1.285; 95% CI, 1.012-1.630), and sensitization on skin prick tests (aOR, 2.596; 95% CI, 2.055-3.279). Risk factors for atopic current AR were the same as those of current AR, whereas breast-milk feeding (aOR, 0.720; 95% CI, 0.530-0.976) was a protective factor. Sensitized allergens as risk factors for current AR were Dermatophagoides pteronyssinus, Dermatophagoides farina, ragweed, mugwort, oak, alder, birch, Japanese hop, cat, and dog.

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“…While the effects of environmental factors certainly depend on genetic susceptibility, exposure to smoking and malnutrition during pre- and post-natal periods are well known risk factors for asthma. Moreover, asthma is triggered and exacerbated by allergens, 29 30 31 32 indoor and outdoor air pollutants, 33 occupational exposures, 34 35 microbial and viral pathogens, 36 37 38 nutrition, 39 40 and lifestyle. 41 42 …”

Section: Introductionmentioning

confidence: 99%

Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects

2015

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Over the past three decades, a large number of genetic studies have been aimed at finding genetic variants associated with the risk of asthma, applying various genetic and genomic approaches including linkage analysis, candidate gene polymorphism studies, and genome-wide association studies (GWAS). However, contrary to general expectation, even single nucleotide polymorphisms (SNPs) discovered by GWAS failed to fully explain the heritability of asthma. Thus, application of rare allele polymorphisms in well defined phenotypes and clarification of environmental factors have been suggested to overcome the problem of 'missing' heritability. Such factors include allergens, cigarette smoke, air pollutants, and infectious agents during pre- and post-natal periods. The first and simplest interaction between a gene and the environment is a candidate interaction of both a well known gene and environmental factor in a direct physical or chemical interaction such as between CD14 and endotoxin or between HLA and allergens. Several GWAS have found environmental interactions with occupational asthma, aspirin exacerbated respiratory disease, tobacco smoke-related airway dysfunction, and farm-related atopic diseases. As one of the mechanisms behind gene-environment interaction is epigenetics, a few studies on DNA CpG methylation have been reported on subphenotypes of asthma, pitching the exciting idea that it may be possible to intervene at the junction between the genome and the environment. Epigenetic studies are starting to include data from clinical samples, which will make them another powerful tool for research on gene-environment interactions in asthma.

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Effect of antibiotic use and mold exposure in infancy on allergic rhinitis in susceptible adolescents

Cited by 21 publications

References 59 publications

Early‐life antibiotic use and subsequent diagnosis of food allergy and allergic diseases

Early‐life antibiotic use and subsequent diagnosis of food allergy and allergic diseases

The prevalence and risk factors of allergic rhinitis from a nationwide study of Korean elementary, middle, and high school students

Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects

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