Early‐life antibiotic use and subsequent diagnosis of food allergy and allergic diseases

Hirsch, Annemarie G.; Pollak, Jonathan; Glass, Thomas A.; Poulsen, Melissa N.; Bailey‐Davis, Lisa; Mowery, Jacob; Schwartz, Brian S.

doi:10.1111/cea.12807

Cited by 84 publications

(83 citation statements)

References 34 publications

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“…A recent human study also identified a strong association between microbial dysbiosis and food allergy incidence. Antibiotic administration during childhood was associated with the onset of various milk and non‐milk food allergies . Furthermore, the class of antibiotic also determined the risk of developing food allergy, suggesting that the depletion of particular bacteria may influence allergy susceptibility.…”

Section: Food Allergy and Dietmentioning

confidence: 99%

The nutrition‐gut microbiome‐physiology axis and allergic diseases

McKenzie

Tan

Macia

et al. 2017

Immunological Reviews

237

202

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Dietary and bacterial metabolites influence immune responses. This raises the question whether the increased incidence of allergies, asthma, some autoimmune diseases, cardiovascular disease, and others might relate to intake of unhealthy foods, and the decreased intake of dietary fiber. In recent years, new knowledge on the molecular mechanisms underpinning a 'diet-gut microbiota-physiology axis' has emerged to substantiate this idea. Fiber is fermented to short chain fatty acids (SCFAs), particularly acetate, butyrate, and propionate. These metabolites bind 'metabolite-sensing' G-protein-coupled receptors such as GPR43, GPR41, and GPR109A. These receptors play fundamental roles in the promotion of gut homeostasis and the regulation of inflammatory responses. For instance, these receptors and their metabolites influence Treg biology, epithelial integrity, gut homeostasis, DC biology, and IgA antibody responses. The SCFAs also influence gene transcription in many cells and tissues, through their inhibition of histone deacetylase expression or function. Contained in this mix is the gut microbiome, as commensal bacteria in the gut have the necessary enzymes to digest dietary fiber to SCFAs, and dysbiosis in the gut may affect the production of SCFAs and their distribution to tissues throughout the body. SCFAs can epigenetically modify DNA, and so may be one mechanism to account for diseases with a 'developmental origin', whereby in utero or post-natal exposure to environmental factors (such as nutrition of the mother) may account for disease later in life. If the nutrition-gut microbiome-physiology axis does underpin at least some of the Western lifestyle influence on asthma and allergies, then there is tremendous scope to correct this with healthy foodstuffs, probiotics, and prebiotics.

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Section: Food Allergy and Dietmentioning

confidence: 99%

The nutrition‐gut microbiome‐physiology axis and allergic diseases

McKenzie

Tan

Macia

et al. 2017

Immunological Reviews

237

202

View full text Add to dashboard Cite

show abstract

“…1 Maternal use of antibiotics before and during pregnancy was associated with an increased risk of cow's milk allergy in the offspring, and persisted after adjusting for putative confounders. 22 A clear association was found between three or more courses of antibiotics during early life and cow's milk allergy, non-milk food allergy and other allergies in a longitudinal data analysis of 30,060 children. 22 The associations became stronger for younger age and differed by antibiotic class.…”

Section: Antibiotics and Immunity And Allergymentioning

confidence: 94%

“…22 A clear association was found between three or more courses of antibiotics during early life and cow's milk allergy, non-milk food allergy and other allergies in a longitudinal data analysis of 30,060 children. 22 The associations became stronger for younger age and differed by antibiotic class. 22 The risk of cow's milk allergy increased with increasing number of child's antibiotics used from birth to diagnosis of the allergy (test for trend P < 0.001).…”

Section: Antibiotics and Immunity And Allergymentioning

confidence: 94%

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Antibiotic treatment in infants: effect on the gastro-intestinal microbiome and long term consequences

2018

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Introduction: The gastrointestinal microbiome is crucial for the development of a balanced immune system. Antibiotics are frequently administered to infants and cause intestinal dysbiosis. This narrative review highlights the long term health consequences of antibiotic administration to infants and young children. The necessity of administration of antibiotics should be well considered, since an association with short term consequences such as antibiotic associated diarrhoea and long term adverse effects such as overweight, inflammatory bowel syndrome, allergic disease have been reported. Conclusion:The pros and cons of antibiotic administration to infants and young children should be considered.

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“…We established that both kill different subsets of prevalent commensal bacteria, and cause cell lysis in specific cases. This species-specific activity challenges the long-standing divide of antibiotics into bactericidal and bacteriostatic, and provides a possible explanation for the strong impact of macrolides on the gut microbiota composition in animals 5-8 and humans 9-11 . To mitigate the collateral damage of macrolides and tetracyclines on gut commensals, we exploited the fact that drug combinations have species-specific outcomes in bacteria 12 and sought marketed drugs, which could antagonize the activity of these antibiotics in abundant gut commensal species.…”

mentioning

confidence: 94%

Dissecting the collateral damage of antibiotics on gut microbes

Maier

Goemans

Pruteanu

et al. 2020

Preprint

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24Antibiotics are used for fighting pathogens, but also target our commensal bacteria as a side 25 effect, disturbing the gut microbiota composition and causing dysbiosis and disease 1-3 . 26Despite this well-known collateral damage, the activity spectrum of the different antibiotic 27 classes on gut bacteria remains poorly characterized. Having monitored the activities of 28 >1,000 marketed drugs on 38 representative species of the healthy human gut microbiome 4 , 29 we here characterize further the 144 antibiotics therein, representing all major classes. We 30 determined >800 Minimal Inhibitory Concentrations (MICs) and extended the antibiotic 31 profiling to 10 additional species to validate these results and link to available data on 32 antibiotic breakpoints for gut microbes. Antibiotic classes exhibited distinct inhibition spectra, 33including generation-dependent effects by quinolones and phylogeny-independence by β-34 lactams. Macrolides and tetracyclines, two prototypic classes of bacteriostatic protein 35 synthesis inhibitors, inhibited almost all commensals tested. We established that both kill 36 different subsets of prevalent commensal bacteria, and cause cell lysis in specific cases. 37This species-specific activity challenges the long-standing divide of antibiotics into 38 bactericidal and bacteriostatic, and provides a possible explanation for the strong impact of 39 macrolides on the gut microbiota composition in animals 5-8 and humans 9-11 . To mitigate the 40 collateral damage of macrolides and tetracyclines on gut commensals, we exploited the fact 41 that drug combinations have species-specific outcomes in bacteria 12 and sought marketed 42 drugs, which could antagonize the activity of these antibiotics in abundant gut commensal 43 species. By screening >1,000 drugs, we identified several such antidotes capable of 44 protecting gut species from these antibiotics without compromising their activity against 45 relevant pathogens. Altogether, this study broadens our understanding of antibiotic action on 46 gut commensals, uncovers a previously unappreciated and broad bactericidal effect of 47 prototypical bacteriostatic antibiotics on gut bacteria, and opens avenues for preventing the48 collateral damage caused by antibiotics on human gut commensals.49 3 MAIN TEXT 50 Medication is emerging as major contributor for changes in the composition of the human gut 51 microbiota 4,13-15 . Such severe and long-lasting changes are associated, and in some cases 52 causatively linked, to dysbiosis and a wide range of diseases 16 . Although several non-53 antibiotic drugs may also have a previously unappreciated impact on the gut microbiome 54 composition 4,16,17 , antibiotics, developed to have broad spectra and thereby target very 55 diverse pathogens, are long known to take a heavy toll on our gut flora, causing a variety of 56 gastrointestinal side-effects 18 , including Clostridioides (former Clostridium) difficile infections. 57Recently more attention has been given to this collateral damage of antibiot...

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Early‐life antibiotic use and subsequent diagnosis of food allergy and allergic diseases

Cited by 84 publications

References 34 publications

The nutrition‐gut microbiome‐physiology axis and allergic diseases

The nutrition‐gut microbiome‐physiology axis and allergic diseases

Antibiotic treatment in infants: effect on the gastro-intestinal microbiome and long term consequences

Dissecting the collateral damage of antibiotics on gut microbes

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