Intravenous Vitamin C and Cancer

Fritz, Heidi; Flower, Gillian; Weeks, Laura; Cooley, Kieran; Callachan, Michael; McGowan, Jessie; Skidmore, Becky; Kirchner, Leesa; Seely, Dugald

doi:10.1177/1534735414534463

Cited by 106 publications

(113 citation statements)

References 96 publications

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“…In recent days, there is an increased interest in studying Vitamin C as an adjunct treatment with chemotherapy (Hoffer et al, 2015;Fritz et al, 2014). Some studies have explored that Vitamin C Induced Ascorbate radical produces hydrogen peroxide which is toxic towards Cancer cells (Jacobs et al, 2015;Stephenson et al, 2013 (Raza et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Vitamin C retards the growth and motility of liver cancer cells huh 7 in wound healing assay

2017

Int. J. Biosci.

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Vitamin C has long been discussed as having anticancer potential but with little evidence on mechanism of action. Some clinical studies have been performed but with no conclusive results. Researchers have been calling for more studies. The aim of study was to investigate the anti-cancer role of high dose Vitamin C on growth and motility of Liver cancer cells Huh 7 in wound healing Assay. Huh-7 cells were cultured in complete medium (DMEM) at 37 o C with 5%

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Section: Discussionmentioning

confidence: 99%

Vitamin C retards the growth and motility of liver cancer cells huh 7 in wound healing assay

2017

Int. J. Biosci.

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“…17 However, at high concentrations (350-450 mg/dL), vitamin C dissociates in extracellular fluid to become an ascorbate radical (AscH , and hence, apoptosis is successfully induced, killing the cells. 11,15,18,19 At the same time, a high concentration of serum vitamin C suppresses the reduction of glutathione, causing it to be present in its oxidized form (GSSG is easily metabolized into oxygen and water by the enzyme catalase in normal, healthy cells. However, the enzyme catalase is missing in tumor cells.…”

Section: Pharmacokinetics Of Vitamin Cmentioning

confidence: 99%

“…This process of selective cytolytic activity allows the effective targeting of tumor cells without simultaneously affecting the body's immune cells. 15 In addition to the absence of catalase, tumor cells selectively take up more vitamin C compared with normal cells because of the upregulation of glucose transporters to facilitate their metabolic needs. [20][21][22] Tumor angiogenesis is the development of new blood vessels toward and into a tumor.…”

Section: Pharmacokinetics Of Vitamin Cmentioning

confidence: 99%

“…15,17 Vitamin C decreases inflammation by suppressing the expression of both COX-2 (cyclo-oxygenase) and nuclear factor κ-lightchain-enhancer of activated B cells (NF-κB). 15 C-reactive protein (CRP), one of the markers of inflammation, was used in certain studies to monitor the effects of IVC therapy. 17 It was found that high levels of CRP correlated with poor prognosis of patients, but this can be controlled with IVC therapy.…”

Section: Pharmacokinetics Of Vitamin Cmentioning

confidence: 99%

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Effects of High Doses of Vitamin C on Cancer Patients in Singapore

Raymond¹,

Glenda²,

Meng

2015

Integr Cancer Ther

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Introduction. Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology; however, a study reviewing its effects has never been performed in Singapore. This article serves to document administration of supportive vitamin C therapy for cancer patients in Singapore. Methods. The clinical response of 9 cancer patients of differing stages to the regular administration of large doses (25-100 g/d) of intravenous vitamin C (IVC; ascorbic acid) is outlined. Tumor pathology and patient health were verified by doctors who do not practice vitamin C treatment. Results. Cases suggesting survival beyond prognosis, improvement in quality of life, safe coadministration with and improved tolerance of conventional therapy, and deterioration in clinical condition following withdrawal of vitamin C therapy are documented clinically. Some patients experience the Jarisch-Herxheimer reaction-the release of endotoxin from microorganism death resulting in pimples, fever, and body odor-for a few hours after the therapy, but these are resolved quickly with no lasting effects. Conclusion. Randomized trials of IVC therapy are recommended because it has minimal side effects and has shown promising results.

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“…As an additional side effect, in glucose-6-phosphate dehydrogenase deficiency AA has been shown to have a hemolytic effect [6]. Intrevenous megadose of vitamin C may result in diarrhea, nausea, headache, decreased appetite and fatigue [16].…”

Section: Shortage and Overdose Of Vitamin Cmentioning

confidence: 99%

Vitamin C and Disease: Insights from the Evolutionary Perspective

Clemens¹,

Tóth²

2013

jevohealth

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The role of vitamin C at the physiological and cellular levels is indisputable. In line with this, blood level of vitamin C is inversely related to disease parameters such as risk of cancer, cardiovascular disease and mortality in prospective cohort and correlational studies. At the same time, adequately powered clinical intervention studies consistently provide no evidence for a beneficial effect of supplementing vitamin C. Here we provide a framework to resolve this apparent conflict. Besides providing an overview of the widely-known facts regarding vitamin C, we review evidence that are of potential relevance but are seldomly mentioned in the context of vitamin C. We invoke the glucose-ascorbate antagonism (GAA) theory which predicts that as a consequence of their molecular similarity glucose hinders the entry of vitamin C into cells. Integrating data coming from research at the cellular level, those from clinical, anthropological and dietary studies, in the present hypothesis paper we propose an evolutionary framework which may synthesize currently available data in the relation of vitamin C and disease. We put forward that instead of taking vitamin C as a supplement, an evolutionary adapted human diet based on meat, fat and offal would provide enough vitamin C to cover physiological needs and to ward off diseases associated with vitamin C deficiency.

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Intravenous Vitamin C and Cancer

Cited by 106 publications

References 96 publications

Vitamin C retards the growth and motility of liver cancer cells huh 7 in wound healing assay

Vitamin C retards the growth and motility of liver cancer cells huh 7 in wound healing assay

Effects of High Doses of Vitamin C on Cancer Patients in Singapore

Vitamin C and Disease: Insights from the Evolutionary Perspective

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