2015
DOI: 10.1177/1534735415622010
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Effects of High Doses of Vitamin C on Cancer Patients in Singapore

Abstract: Introduction. Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology; however, a study reviewing its effects has never been performed in Singapore. This article serves to document administration of supportive vitamin C therapy for cancer patients in Singapore. Methods. The clinical response of 9 cancer patients of differing stages to the regular administration of large doses (25-100 g/d) of intravenous vitamin C (IVC; ascorbic acid) is outlined. Tumor pathology and pati… Show more

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Cited by 30 publications
(25 citation statements)
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“…Instead they found that supplementary vitamin D was strongly associated with lessened disability for knee OA patients (28). Some studies report in oncology that the use of Vitamin C improves the quality of life of the oncological patient (29, 30). However, the reduction in quality of life is led to the reduction of pain.…”
Section: Discussionmentioning
confidence: 99%
“…Instead they found that supplementary vitamin D was strongly associated with lessened disability for knee OA patients (28). Some studies report in oncology that the use of Vitamin C improves the quality of life of the oncological patient (29, 30). However, the reduction in quality of life is led to the reduction of pain.…”
Section: Discussionmentioning
confidence: 99%
“…There is an acknowledged need for good clinical studies to determine the anticancer efficacy of this practice and to establish appropriate clinical guidelines. Case reports suggest that there may be circumstances under which vitamin C can provide a clinical benefit (these are usually high intravenous doses, given as a course over months) ( Drisko et al, 2003 ; Padayatty et al, 2006 ; Mikirova et al, 2016 ; Raymond et al, 2016 ) and recent phase I trials have indicated that high-dose vitamin C is a useful adjunct to chemotherapy ( Welsh et al, 2013 ; Hoffer et al, 2015 ). However, given the prevalence of ascorbate use by cancer patients, clinical advantage is not commonly seen, suggesting that only a subset of patients may benefit.…”
Section: Introductionmentioning
confidence: 99%
“…Pharmacokinetic studies in humans have shown that intravenous administration of sodium L-ascorbate can generate up to 30 mM peak plasma levels, 100-fold higher than the levels produced by high-dose oral administration, and is not toxic due to the rapid elimination (a few hours [19,58]). Recent clinical trials and case studies have shown efficacy of vitamin C as an anticancer agent when administered IV at high doses ranging from 0.4 to 1.5 g ascorbate/kg body weight to treat patients with a variety of solid tumors including breast, ovarian, prostate, kidney, lung, and liver cancer [72,[97][98][99][100][101][102]. Recently, high-dose vitamin C was shown to be selectively toxic to KRAS or BRAF mutant colorectal cancer cells [93].…”
Section: Medical Significance Of the Modelmentioning
confidence: 99%