Vitamin C May Help to Reduce the Knee's Arthritic Symptoms. Outcomes Assessment of Nutriceutical Therapy

Ripani, Umberto; Manzarbeitia-Arroba, Paloma; Guijarro-Leo, Sandra; Urrutia-Graña, Javier; Luca, Alessandra De

doi:10.5455/medarh.2019.73.173-177

Cited by 20 publications

(15 citation statements)

References 24 publications

(23 reference statements)

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“…Vitamin C is an important nonenzymatic antioxidant that helps reduce free radical damage. Recent studies have shown that vitamin C can have beneficial effects in patients with early KOA [ 49 ]. There are two isoforms of vitamin C transporters that are sodium dependent.…”

Section: Ros and Antioxidantsmentioning

confidence: 99%

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi

Totu

Fifere³

et al. 2021

Antioxidants

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Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA.

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Section: Ros and Antioxidantsmentioning

confidence: 99%

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi

Totu

Fifere³

et al. 2021

Antioxidants

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show abstract

“…As mentioned previously, antioxidants and nutritional supplements showed good efficacy against pain in this survey. Some studies provide a rationale for the beneficial effects of antioxidant supplements as vitamin C, E, and others in the treatment of early cases of OA 34,8 . These studies indicated that the patients who received the antioxidants had long-term better results on pain however, other authors suggested that daily intake of vitamin C showed no statistical significance with lowered dysfunction for knee 35 .In general, vitamin C appears to be a safe and efficacious adjunctive therapy for pain relief in patients with OA 36 .…”

Section: Discussionmentioning

confidence: 99%

“…For some individuals, it may be hereditary. For others, osteoarthritis of the knee or in other joints can result from injury or infection 8 . Other risk factors include; gender (more common in females), occupation, sedentary life, ethnicity, obesity, diet and bone density 7 .…”

Section: Introductionmentioning

confidence: 99%

Comparing the Responses of Patients with Osteoarthritis to Some Pharmacological and Non-Pharmacological Treatment Modalities, Cross Sectional Survey

Sahar El-Ashmony

2021

Indian Journal of Forensic Medicine & Toxicology

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Objective: Osteoarthritis (OA) is the most common form of arthritis, and is a leading cause of disability among older adults. Many different therapeutic strategies are used in OA management including both pharmacological and non-pharmacological modalities with various patient responses. However, a perfect therapy for OAis still to be found.This research aims to compare the degree of pain improvement in osteoarthritic patients in response to various treatment modalities through an online questionnaire.Methods: This descriptive cross-sectional study was conducted in January 2020 in Makkah, Saudi Arabia, and Cairo, Egypt. The total sample obtained was 1,870 residents with OA. A computer-based survey of osteoarthritis was conducted electronically. Results:The highest age range of participants was between 41-50 years (65%). More than two-thirds (1210) were females.The knee is significantly (P<0.005) the most common joint affected followed by back and neck. Concerning the treatment modalities asked in the questionnaire; physical/hydrotherapy, joint injection, and paracetamol are significantly (P<0.005) the most commonly used by participants.The number of participants those indicates the highest responses to pain improvement (50 % and more) to paracetamol, glucosamine/ chondroitin, nutritional supplements, and antioxidants were significantly (P<0.005) more than those for other treatment modalities Conclusion:The most commonly used treatment methods for osteoarthritic pain were physiotherapy/ hydrotherapy, joint injection, and oral paracetamol. Those who have achieved the highest response regarding pain improvement were paracetamol, antioxidants, glucosamine / chondroitin, and nutritional supplements.

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“…12,58 Recent studies have examined the role of vitamin C supplementation to potentiate patient outcomes following ACL reconstruction and total knee arthroplasty (TKA). 7,[59][60][61][62] Barker et al 62 sought to determine the effect of preoperative vitamin C supplementation on inflammation following ACL reconstruction. A total of oxidant group, receiving 500 mg vitamin C and 200 IU of vitamin E twice daily, or the matching placebo.…”

Section: Acl Reconstruction and Knee Arthroplastymentioning

confidence: 99%

“…Similarly, some studies have evaluated the role of vitamin C supplementation in the outcomes of patients who undergo knee replacement surgery 7,59–61 . Behrend et al 7 investigated whether perioperative vitamin C supplementation impacts knee range of motion and risk of arthrofibrosis (AF) following TKA.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C in orthopedic practices: Current concepts, novel ideas, and future perspectives

Oakes

Bolia

Weber

et al. 2021

Journal Orthopaedic Research

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Vitamin C (ascorbic acid), is an important antioxidant that has been applied broadly in the field of orthopaedics. Current research on vitamin C examines the molecule's role in bone and tendon physiology, as well as joint replacement and Postoperative pain. Most laboratory and human studies associate the use of vitamin C with improved bone health and tendon healing. Recent literature moderately supports the use of vitamin C to improve functional outcomes, decreased postoperative pain, and prevent complex regional pain syndrome following orthopaedic procedures. The perioperative use of vitamin C in patients undergoing joint replacement surgery and anterior cruciate ligament reconstruction is still under investigation. Overall, there is need for high-quality human trials to confirm whether vitamin C can potentiate the outcomes of orthopaedic procedures and to determine optimal dosage and means of administration to maximize its proposed benefits. The purpose of this review was to summarize the application of vitamin C in orthopaedic practices and to identify potential areas for future study. K E Y W O R D S bone, orthopedics, pain management, tendons, vitamin C 1 | INTRODUCTION Vitamin C (ascorbic acid), is an important antioxidant and deficiency of this mineral is most often associated with scurvy. 1 Vitamin C is vital to the production of collagen in both bone and connective tissue and it has been associated with improved collagen synthesis and subsequent tendon healing. 2-4 It also neutralizes free radicals, which helps to decrease oxidative stress and inflammation. 5 Vitamin C has also been used as a supplement in orthopaedic patients. 6-8 Vitamin C has been linked to improved bone mineral density as well as decreased risk of bone fracture and osteoporosis. 9-11 Furthermore, there is recent evidence to suggest that vitamin C may have a protective role in osteoarthritis. 12 From a postoperative recovery perspective, vitamin C has been found to reduce the incidence of complex regional pain syndrome (CRPS) and improve functional outcomes. 5,13 However, some of these conclusions on the therapeutic effect of vitamin C continue to be debated. 14 The purpose of this review was to summarize the role of vitamin C in orthopaedic practices and to identify potential areas for future study. 1.1 | Perioperative pain management Postoperative pain exists as a common challenge to orthopaedic surgeons, as it is linked to increased risk of postoperative complications, longer hospital stays, and significant delays in the return to regular function. 15 Opioids, such as morphine, may be prescribed to limit postoperative pain in orthopedic patients; however, there are a multitude of side effects associated with their use

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Vitamin C May Help to Reduce the Knee's Arthritic Symptoms. Outcomes Assessment of Nutriceutical Therapy

Cited by 20 publications

References 24 publications

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Comparing the Responses of Patients with Osteoarthritis to Some Pharmacological and Non-Pharmacological Treatment Modalities, Cross Sectional Survey

Vitamin C in orthopedic practices: Current concepts, novel ideas, and future perspectives

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