Vitamin D Status and Adequacy of Standard Supplementation in Preterm Neonates From South India

Tergestina, Mintoo; Jose, Arun; Santhanam, Sridhar; Job, Victoria; Rebekah, Grace; Kuruvilla, K; Thomas, Niranjan

doi:10.1097/mpg.0000000000000296

Cited by 13 publications

(9 citation statements)

References 27 publications

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“…In the present study, 98.9% of preterm infants had vitamin D insufficiency or deficiency, and 51.1% of preterm infants were severely vitamin D deficient. These results showed much lower 25-OHD concentrations compared to those reported in previous studies of preterm infants 13 14 15 16 17 18) , and also were lower than those in previous reports on Korean newborns 3 19 20) . Although almost all infants had vitamin D insufficiency or deficiency, the serum concentrations of calcium, phosphorous and ALP at birth were maintained within the normal range.…”

Section: Discussioncontrasting

confidence: 79%

“…Our study reports the lowest 25-OHD concentrations of preterm infants published to date, as far as we have been able to determine. The previous studies involved preterm infants with younger gestational age compared to that in the present study 13 14 15 16 17 18) , but the 25-OHD concentrations were much higher than those of preterm infants in the present study. The 25-OHD concentrations were even lower than those of infants in Northern European countries including Norway (12.2±5.5 ng/mL) 23) , and Finland (11.7±4.7 ng/mL) 24) .…”

Section: Discussioncontrasting

confidence: 61%

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Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features

et al. 2015

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PurposeWe investigated the vitamin D status of preterm infants to determine the incidence of vitamin D deficiency.MethodsA total of 278 preterm infants delivered at Kyungpook National University Hospital between January 2013 and May 2015 were enrolled. The serum concentrations of calcium, phosphorous, alkaline phosphatase, and 25-hydroxyvitamin D (25-OHD) were measured at birth. We collected maternal and neonatal data such as maternal gestational diabetes, premature rupture of membranes, maternal preeclampsia, birth date, gestational age, and birth weight.ResultsMean gestational age was 33+5±2+2 weeks of gestation and mean 25-OHD concentrations were 10.7±6.4 ng/mL. The incidence of vitamin D deficiency was 91.7%, and 51.1% of preterm infants were classified as having severe vitamin D deficiency (25-OHD<10 ng/mL). The serum 25-OHD concentrations did not correlate with gestational age. There were no significant differences in serum 25-OHD concentrations or incidence of severe vitamin D deficiency among early, moderate, and late preterm infants. The risk of severe vitamin D deficiency in twin preterm infants was significantly higher than that in singletons (odds ratio, 1.993; 95% confidence interval [CI], 1.137-3.494, P=0.016). In the fall, the incidence of severe vitamin D deficiency decreased 0.46 times compared to that in winter (95% CI, 0.227-0.901; P=0.024).ConclusionMost of preterm infants (98.9%) had vitamin D insufficiency and half of them were severely vitamin D deficient. Younger gestational age did not increase the risk of vitamin D deficiency, but gestational number was associated with severe vitamin D deficiency.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussioncontrasting

confidence: 61%

Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features

et al. 2015

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“…Tergesti et al also reported no improvement in vitamin D deficiency with supplementation at 400 IU daily. In fact, the percentage of VDD was 12.6% at birth and it increased to 52.2% at 6 weeks [11]. In a recently published randomized doubled-blind controlled trial comparing the effect of vitamin D supplementation at 400 vs. 1000 IU daily in a group of preterm neonate at 24 to 27 weeks gestation, mean 25OHD concentration increased from 21.3 ng/mL to 47.5 ng/mL at 40 weeks CGA in the 1000 IU daily group, but mean 25OHD concentration in 400 IU daily group decreased from 31.3ng/mL to 17.5 ng/mL.…”

Section: Discussionmentioning

confidence: 98%

Vitamin D Status in Premature Infants at Risk of Metabolic Bone Disease of Prematurity

J¹,

Ac²,

Kelly³

2017

Matern Pediatr Nutr

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Objectives: The purpose of this study is to report the vitamin D status in a group of premature infants with increased risk of MBD and to describe the relationship between their vitamin D status and intake.Methods: Retrospective descriptive study in in a level IV neonatal intensive care unit. Results:One hundred and fifty-two subjects were included in the study. Mean gestational age was 26.8 ± 3.3 weeks and mean age was 157 ± 93 days. Mean serum 25OHD concentration was 57.8 ± 2.0 mg/mL. The prevalence of 25OHD <20 ng/mL and 25OHD >100 ng/mL was 5.9% (n=9) and 8.6% (n=13), respectively. No association between 25OHD level and vitamin D intake with respect to total daily dose (p=0.43) or total daily dose based on body weight (p=0.812) was found. Younger gestational age and younger chronological age were associated with wider range of 25OHD levels. Conclusions:Both suboptimal and elevated 25OHD concentrations are found with our current protocol for supplementation. Vitamin D status in premature infants does not correlate with their vitamin D intake, but younger gestational age and chronological age are both associated with more diverse range of 25OHD.

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“…Therefore, premature infants are at risk for vitamin D deficiency . And several studies have suggested this finding . Ataseven et al investigated vitamin D levels of 152 infants born 29–35 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, in animal studies it has been demonstrated that vitamin D improves lung structure after hyperoxia‐induced lung injury and intra‐amniotic endotoxin exposure . Preterm infants have risks of developing vitamin D deficiency and BPD compared with that of full‐term infants . Recommendations for daily vitamin D intake is miscellaneous .…”

Section: Introductionmentioning

confidence: 99%

Protective effect of vitamin D against hyperoxia-induced lung injury in newborn rats

et al. 2016

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Vitamin D Status and Adequacy of Standard Supplementation in Preterm Neonates From South India

Cited by 13 publications

References 27 publications

Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features

Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features

Vitamin D Status in Premature Infants at Risk of Metabolic Bone Disease of Prematurity

Protective effect of vitamin D against hyperoxia-induced lung injury in newborn rats

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