Protective effect of vitamin D against hyperoxia-induced lung injury in newborn rats

Köse, Mehmet; Baştuğ, Osman; Sönmez, Mehmet Fatih; Per, Sedat; Özdemır, Ahmet; Kaymak, Emin; Yahşi, Hande; Öztürk, Mehmet

doi:10.1002/ppul.23500

Cited by 19 publications

(24 citation statements)

References 28 publications

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“…Our previous study found that vitamin D receptor-knockout mice showed a more intense inflammatory response to LPS and vitamin D treatment decreased the secretion of pro-inflammatory cytokines in LPS-induced lung injury (11). The anti-apoptotic role of vitamin D was also demonstrated in pulmonary tissue (10). Agonists of vitamin D receptor relieved cardiomyocyte apoptosis in a model of myocardial ischemic-reperfusion (27).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4

Yao

Shi

Zhao

et al. 2017

International Journal of Molecular Medicine

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With considerable morbidity and mortality, bron-chopulmonary dysplasia (BPD) is a focus of attention in neonatology. Hyperoxia-induced lung injury has long been used as a model of BPD. Among all the signaling pathways involved, Toll-like receptor 4 (TLR4) has been demonstrated to play an important role, and is known to be regulated by vitamin D. This study aimed at elucidating the effect of vitamin D on hyperoxia-induced lung injury and the role of TLR4 in the process. Vitamin D was administered to hyperoxia-treated neonatal rats to investigate changes in the morphology of lungs and expression of pro-inflammatory cytokines, apoptotic proteins and TLR4. Vitamin D attenuated hyperoxia-induced lung injury by protecting the integrity of the lung structure, decreasing extracellular matrix deposition and inhibiting inflammation. The upregulation of TLR4 by hyperoxia was ameliorated by vitamin D and apoptosis was reduced. Vitamin D administration antagonized the activation of TLR4 and therefore alleviated inflammation, reduced apoptosis and preserved lung structure.

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Section: Discussionmentioning

confidence: 99%

Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4

Yao

Shi

Zhao

et al. 2017

International Journal of Molecular Medicine

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“…In our study, we took the experimental hyperoxia model as reference and formed the chain of inflammatory events. 12 These were divided into four groups: normoxia control group (group-1), normoxia+lycopene group (group-2), hyperoxia control group (group--3) and hyperoxia+lycopene group (group-4); there were 10 newborn rats in each group. The dosage study by Bignotto et al 13 has been taken as a basis for the anti-inflammatory effect of lycopene.…”

Section: Methodsmentioning

confidence: 99%

“…; and, finally, the group-4 was given a single dose of lycopene along with oxygen above 85 %. 12 The study was completed on the postnatal 11th day and the animals were sacrificed. The brain tissues were quickly removed and used for histological analysis and ELISA studies ( Figure 1).…”

Section: Methodsmentioning

confidence: 99%

“…Identified tissues were washed under tap water and dehydrated using a graded alcohol series. 12 Tissues were kept in alcohol series concentrated by 50-70-80 and 100 %, respectively, for one hour in each, and thus, their water content was removed to saturate the tissues with alcohol. Tissues were made transparent using xylol and embedded in paraffin.…”

Section: Histopathological Assessmentmentioning

confidence: 99%

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Can lycopene eliminate the harmful effects of hyperoxia in an immature brain?

Özdemır¹,

Baştuğ²,

Çilenk

et al. 2019

Arch Argent Pediat

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Objectives. In addition to protecting cells against free radical harm thanks to its anti-oxidant nature, lycopene strengthens the bonds among cells and improves cell metabolism. This study focuses on analyzing therapeutic effects of lycopene in hyperoxia-induced neurodegenerative disorders in newborn rats. Methods. Term newborn rats were divided into four groups as the normoxia control group (group-1), normoxia+lycopene group (group-2), hyperoxia control group (group-3) and hyperoxia+lycopene group (group-4). Group-1 and group-2 were monitored in room air while the group-3 and group-4 were monitored at > 85% O 2. The group-2 and group-4 were injected with lycopene intrapertioneally (i.p.) at 50mg/ kg/day while the other groups were injected with corn oil i.p. at the same volume. The rats we sacrificed on the 11 th day following the 10-day hyperoxia. The brains were removed and oxidant system parameters were assessed. Results. Injury resulting from hyperoxia was detected in the white matter, cortical regions, and thalamus of the brains. It was observed that the number of apoptotic cells increased and the number of proliferating cell nuclear antigen (PCNA) positive cells decreased in the groups-3 and 4 compared to the group-1. No significant improvement in the number of apoptotic cells and PCNA positive cells was observed in the groups-3 and 4, and apoptosis increased as well. Conclusion. This study found that lycopene, did not show any therapeutic effects for brain damage treatment in newborn rats. In addition, this study demonstrated that lycopene might lead to toxic effects.

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“…Two studies in Pediatric Pulmonology published in 2017 used relatively high oxygen concentrations over a prolonged period, well past the initiation of the saccular stage of lung development, and inevitably productive of ROS levels unlikely to be experienced in neonatal intensive care. Kose et al to their credit tested varied doses of vitamin D on hyperoxia‐impaired lung development in newborn Wistar rats, and found that there were dose‐dependent, reciprocal effects on TUNEL‐labeled cells and proliferating cell nuclear antigen positive cells. This is a useful advance as effects of vitamin D on cell proliferation and differentiation are known to be concentration dependent .…”

Section: Experimental and Clinical Bpd And Sequelaementioning

confidence: 99%

2017 pediatric pulmonology year in review part 2—neonatology

Auten

2018

Pediatric Pulmonology

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Protective effect of vitamin D against hyperoxia-induced lung injury in newborn rats

Abstract: Vitamin D seems to protect hyperoxia-induced lung injury in newborn rats. Pediatr Pulmonol. 2017;52:69-76. © 2016 Wiley Periodicals, Inc.

Cited by 19 publications

References 28 publications

Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4

Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4

Can lycopene eliminate the harmful effects of hyperoxia in an immature brain?

2017 pediatric pulmonology year in review part 2—neonatology

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