Riboflavin Intake and 5-Year Blood Pressure Change in Chinese Adults: Interaction with Hypertensive Medication

Shi, Zumin; Bao, Yuan; Taylor, Anne; Zhen, Shiqi; Zuo, Hui; Dai, Yue; Wittert, Gary

doi:10.1177/156482651403500105

Cited by 5 publications

(4 citation statements)

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“…In a large, observational study of 6076 Irish adults, the low or deficient biomarker status of riboflavin was about 30% and exacerbated the genetic risk of hypertension associated with the MTHFR 677TT genotype [37]. In a five-year cohort study of Chinese adults, a higher riboflavin intake was found to be inversely associated with a change in systolic blood pressure [16].…”

Section: Discussionmentioning

confidence: 99%

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Riboflavin Intake Inversely Associated with Cardiovascular-Disease Mortality and Interacting with Folate Intake: Findings from the National Health and Nutrition Examination Survey (NHANES) 2005–2016

Shi

2022

Nutrients

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The association between intakes of riboflavin and mortality has not been examined intensively in general populations. In this study, 10,480 adults in the 2005–2016 National Health and Nutrition Examination Survey (NHANES) were followed-up until 2019 for their vital status. Riboflavin and folate were assessed by two-day 24 h recall. The date and cause of death were obtained from the US Mortality Registry. The risks of all-cause mortality and cardiovascular disease (CVD) mortality were investigated using a Cox regression analysis. During a mean of 8.5 years follow-up, there were 1214 deaths registered (including 373 deaths from CVD and 302 from cancer). Compared to low level (quartile 1, Q1) of riboflavin intake, the hazard ratios (HRs) (95% confidence interval (CI)) for high level (quartile 4, Q4) were 0.53 (0.31–0.90) for CVD mortality and 0.62 (0.48–0.81) for all-cause mortality. The inverse association between riboflavin intake and CVD mortality was only significant among those with a high intake of folate (p for interaction 0.045). Those with a high folate intake (Q4) and low intake of riboflavin (Q1) had the highest risk of CVD mortality (HR 4.38, 95% CI 1.79–10.72), as compared with a high intake of both riboflavin and folate. In conclusion, riboflavin intake was inversely associated with all-cause mortality and CVD mortality, and the association was modified by folate intake.

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Section: Discussionmentioning

confidence: 99%

“…Studies of public health relevance have related to the importance of riboflavin as a factor in protecting against CVD, cancers, and in vision [15,16]. Yet, its relationship with mortality has not been investigated, unlike other vitamin B family members.…”

Section: Introductionmentioning

confidence: 99%

Riboflavin Intake Inversely Associated with Cardiovascular-Disease Mortality and Interacting with Folate Intake: Findings from the National Health and Nutrition Examination Survey (NHANES) 2005–2016

Shi

2022

Nutrients

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“…Accordingly, considering the high content of bioactive compounds and phytochemicals in plant foods [160], a personalized nutrition (Figure 1) should take into account potential food-drug interactions in veterans who are in treatment for comorbidities. In agreement, dietetic interventions based on personalized dietary advice have also been suggested for old subjects [161], in order to avoid potential food-drug interactions [162][163][164][165][166][167][168][169][170]. In particular, the effect of high-protein, low-carbohydrate diets on warfarin efficacy should be taken into consideration [169,170].…”

Section: Healthy Diet For Veteransmentioning

confidence: 99%

Nutraceutical-based Integrative Medicine: Adopting a Mediterranean Diet Pyramid for Attaining Healthy Ageing in Veterans with Disabilities

Ciccotti¹,

Raguzzini

Sciarra³

et al. 2019

CPD

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Veterans with disability represent a big burden worldwide and often require long-term rehabilitation. Unhealthy dietary and lifestyle habits, including smoke and alcohol abuse, are common in veterans. In the context of integrative medicine approaches, the "complementary and alternative medicine" has been suggested for the management of chronic diseases. However, the potential risk of interaction between herbal products, dietary supplements and drugs must be considered in veterans. The Mediterranean diet has been suggested as a natural, non-pharmacological nutraceutical for healthy ageing. Although there is a broad consensus on the positive effect of plant foods consumption, the presence of glucosinolates, flavonoids and furanocoumarins in some plant foods and beverages must be taken into consideration owing to their potential interfering with drugs metabolism and bioavailability. Albeit seasonality could ensure the maintenance of the single dose of phytochemical below that at which adverse effects in some individuals genetically predisposed or unpleasant drug interactions in diseased subjects can occur, a personalized nutrition is recommended in veterans who are under treatment for comorbidities. Furthermore, sports practice can lead veterans with motor disabilities and mental impairments to excel in some disciplines, giving rise to the phenomenon of the Paralympics and the development of "recreational therapy". Moreover, outdoor lifestyle, through vitamin D synthesis, and conviviality, improving socialization, could account for the Mediterranean lifestyle health benefits. In this work, we propose for veterans a Mediterranean Pyramid, which could be the basis for integrative medicine for veterans with disabilities, patient-centered approaches and interprofessional (including physical medicine and rehabilitation clinicians, pharmacists and nutritionists) interventions.

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“…To our knowledge, all human studies on riboflavin and bone health were conducted so far in Western countries, where riboflavin intake is generally higher (average intake ranged from 1.5 to 2.0 mg/d) ( 14 , 16 , 17 ). However, the mean dietary intake of riboflavin in Chinese population is around 0.80 mg/d ( 18 ), which is lower than the recommended dietary intake (1.2–1.4 mg/d) and there is a relatively high prevalence of osteoporosis in China. However, the evidence for the association between riboflavin intake and BMD is lacking in Chinese population.…”

Section: Introductionmentioning

confidence: 99%

There is a significantly inverse relationship between dietary riboflavin intake and prevalence of osteoporosis in women but not in men: Results from the TCLSIH cohort study

Wan¹,

Wang²,

Wang³

et al. 2023

Front. Nutr.

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BackgroundEpidemiological evidence for the relationship between riboflavin intake and bone health is inconsistent, and this relationship has not been examined in Chinese population. This study aimed to investigate the relationship between dietary intake of riboflavin and prevalence of osteoporosis in a Chinese adult population.MethodsA total of 5,607 participants (mean age, 61.2 years; males, 34.4%) were included in this cross-sectional study. We calculated the riboflavin intake by using the food frequency questionnaire (FFQ) in combination with Chinese food composition database. Bone mineral density (BMD) was detected by an ultrasound bone densitometer. Multivariable logistic regression models were used to evaluate the relationship between dietary riboflavin intake and prevalence of osteoporosis.ResultsIn this population, the dietary intake of riboflavin ranged from 0.13 to 1.99 mg/d, and the proportion of abnormal BMD was 36.6%. The prevalence of osteoporosis decreased gradually with increasing quartiles of riboflavin intake, before and after adjustment for a range of confounding factors. In the final model, the multivariate-adjusted ORs (95% CI) across the quartiles of riboflavin intake were 1.00 (reference), 0.84 (0.54, 1.31), 0.59 (0.34, 1.04), and 0.47 (0.22, 0.96), respectively (P for trend < 0.05). In sex-disaggregated analysis, similar results to the total population were observed in women, while no significant results were found in men.ConclusionThe dietary riboflavin intake was negatively associated with the prevalence of osteoporosis. However, the association was significant in women but not in men. Our findings indicated that women are more sensitive to riboflavin intake in maintaining a normal BMD.

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Riboflavin Intake and 5-Year Blood Pressure Change in Chinese Adults: Interaction with Hypertensive Medication

Abstract: Background. One previous large cross-sectional study across four countries suggests that riboflavin intake may be inversely associated with blood pressure.Objective.

Cited by 5 publications

References 28 publications

Riboflavin Intake Inversely Associated with Cardiovascular-Disease Mortality and Interacting with Folate Intake: Findings from the National Health and Nutrition Examination Survey (NHANES) 2005–2016

Riboflavin Intake Inversely Associated with Cardiovascular-Disease Mortality and Interacting with Folate Intake: Findings from the National Health and Nutrition Examination Survey (NHANES) 2005–2016

Nutraceutical-based Integrative Medicine: Adopting a Mediterranean Diet Pyramid for Attaining Healthy Ageing in Veterans with Disabilities

There is a significantly inverse relationship between dietary riboflavin intake and prevalence of osteoporosis in women but not in men: Results from the TCLSIH cohort study

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